Augmentin 625 Duo Tablet

• Upper respiratory tract infections (sinusitis, tonsillitis, otitis media)
• Lower respiratory tract infections (bronchitis, pneumonia)
• Urinary tract infections (cystitis, prostatitis)
• Skin and soft tissue infections
• Dental infections
• Bone and joint infections
• Other infections (such as sepsis)

• A history of serious hypersensitivity reactions (such as anaphylaxis) to amoxicillin, clavulanic acid, penicillin, any component of the formulation, or other beta-lactam antibiotics.
• Previous episodes of cholestatic jaundice or hepatic dysfunction associated with amoxicillin/clavulanate therapy.

• Diarrhoea
• Nausea
• Vomiting
• Skin rash
• Abdominal discomfort

Other General Warnings

• You have experienced allergy after the use of antibiotics like amoxicillin (penicillin, cephalosporins).
• Use with caution in patients with liver impairment
• Dose adjustment may be required in patients with kidney impairment.
• Prolonged use may result in antibiotic resistant. Thus, it should not be used longer than the prescribed duration.2
• you have glandular fever (infectious mononucleosis), as this medicine may increase the risk of a skin rash.
• Patients should be monitored for signs of hypersensitivity reactions.

• Take exactly as prescribed by the doctor.
• Swallow the tablet whole with water. Do not chew the tablet.
• Do not break or crush the tablet.
• Take the tablet at the start of a meal to improve absorption and reduce gastrointestinal side effects.
• Complete the full prescribed course even if symptoms improve earlier.

• Store according to the instructions provided with the product (generally below 25°C).
• Keep out of reach of children.
• Do not use after the expiry date.
• Dispose of unused medicine according to local regulations and the doctor’s advice.

• Take the medicine at evenly spaced intervals.
• Preferably taken with food.
• Complete the entire course as prescribed.
• Inform your doctor about any history of penicillin allergy.
• Drink plenty of water while taking this medicine, especially if you are taking high doses, unless your doctor has advised otherwise.
• Seek immediate medical attention if a severe rash, breathing difficulty, or persistent diarrhoea occurs.
• Do not share your antibiotic with others.

Overdose

• Your doctor will determine the appropriate dosage depending on the infection being treated, its severity, your age, weight, and renal function. The commonly used adult Augmentin 625 formulation contains 500 mg amoxicillin and 125 mg clavulanic acid.
• Symptoms of overdose may include gastrointestinal disturbances and fluid or electrolyte imbalance. In some cases, overdose has been associated with crystal formation in the urine (crystalluria) and kidney-related complications. In case of an overdose, you should seek immediate medical attention or contact a doctor.

Missed a Dose

How Does It Work?

• The main ingredients in this medication work together by:
• Amoxicillin acts by inhibiting bacterial cell wall synthesis, leading to bacterial cell death.
• Clavulanic acid inhibits enzymes produced by certain bacteria, thereby protecting amoxicillin from degradation and enhancing its antibacterial activity against susceptible bacteria.

Interactions with other medicines

• Taking methotrexate (used in cancer treatment) along with this medicine can heighten the risk of side effects.
• Medicines such as allopurinol and probenecid (used for the treatment of gout) and medicines used to modify immune response during organ transplant, like mycophenolate mofetil, should be used cautiously with the Augmentin 625 Duo tablet.
• Tell your doctor about any other medicine, supplement or herbal preparations you are currently taking or might take to avoid any interaction.

Interactions with food items