Zerodol SP Tablet
Description
Zerodol-SP is one of the most widely prescribed medicines to treat pain (moderate to severe). It also helps in treating pain that is accompanied by swelling and inflammation. Zerodol-SP is a powerful combination medicine designed to relieve throbbing toothaches, painful joints, or swelling after an injury from three different aspects. This medicine provides fast-acting relief.
Zerodol-SP is much more than a simple painkiller. It is a sophisticated and triple-action formula medicine whose composition contains aceclofenac, paracetamol, and serratiopeptidase as its main ingredients. Aceclofenac and paracetamol are powerful painkillers, and serratiopeptidase is a special enzyme that breaks down the substances that cause swelling and promotes faster healing.
The most common side effects of Zerodol-SP are related to the stomach, such as nausea, indigestion, stomach pain, and diarrhoea. To avoid these issues, it is very important to always take the tablet with food or a glass of milk. You should never take this medicine on an empty stomach. It's also crucial to avoid drinking alcohol while taking Zerodol-SP, as this can severely increase your risk of stomach bleeding and liver damage.
The usual dose for adults is one tablet, once or twice a day, as prescribed by a doctor. You should never take more than the recommended dose. Zerodol-SP is intended for short-term use only. If you have a history of stomach ulcers, kidney or liver problems, or if you are pregnant or breastfeeding, you must consult your doctor before taking this medicine. If your pain does not improve after a few days, stop taking the tablet and seek medical advice.
Product Summary
Offer Price | ₹101.97 |
You Save | ₹37.72 (27% on MRP) |
Contains | Aceclofenac(100.0 Mg)+Serratiopeptidase(15.0 Mg)+Paracetamol / Acetaminophen(325.0 Mg) |
Uses | Muscle pain, Joint pain, Swelling, and Inflammation |
Side effects | Stomach pain, constipation, diarrhoea, bloating, stomach ulcers |
Therapy | ANALGESIC/ANTIPYRETIC |
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Uses
- For tooth Pain and toothache: When you have a toothache, the pain is often caused by inflammation in the gums or the tooth's pulp. Zerodol-SP for tooth pain works perfectly because aceclofenac and paracetamol block the pain signals, while Serratiopeptidase reduces the gum swelling, providing complete relief from the throbbing pain and discomfort....
- Relief from Joint Pain (Osteoarthritis & Rheumatoid Arthritis): Zerodol-SP is widely prescribed to manage the pain and inflammation associated with joint conditions. In osteoarthritis, it helps relieve the pain from cartilage wear and tear. In rheumatoid arthritis, it helps reduce the painful swelling and stiffness in the joints caused by the body's immune system attacking them....
- Back Pain, Neck Pain, and Spondylitis: For conditions such as lower back pain, a stiff neck, or ankylosing spondylitis, Zerodol-SP provides relief by reducing inflammation in the spine and relaxing the muscles....
- Post-Surgical Pain and Swelling: After a minor surgery or a dental procedure, the body's natural response is to create inflammation and swelling at the site. The Serratiopeptidase in Zerodol-SP helps to clear away the excess fluid and proteins, reducing swelling and bruising, which in turn speeds up the healing process....
- Pain from Injuries (Sprains and Strains): For sports injuries, sprains, or muscle strains, Zerodol-SP works to alleviate the immediate pain, control the inflammation, and reduce the swelling, helping you recover more comfortably....
Contraindications
- If you have a known allergy or hypersensitivity to aceclofenac, paracetamol, serratiopeptidase, aspirin, or any other NSAIDs (like Ibuprofen), or any of the ingredients of this medicine.
- If you have a history of asthma attacks, severe skin rashes, or allergic reactions after taking other painkillers.
- If you have an active or a history of frequent stomach ulcers, or have experienced bleeding or perforation in any part of your digestive system, stomach, or intestines.
- If you are in your third trimester of pregnancy.
- If you suffer from severe heart failure, liver disease, or kidney disease.
Side effects
- Nausea, vomiting, or diarrhoea
- Stomach pain
- Indigestion
- Heartburn
- Loss of appetite
- Dizziness or headache
- Severe allergic reactions such as rashes, hives, difficulty breathing, or swelling of the face, lips, tongue, or throat
- Bleeding in the stomach
- Black, tarry, or bloody stools
- Coughing up blood or vomit that looks like coffee grounds
- Chest Pain
- Weakness
- Shortness of Breath
- Jaundice (yellowing of skin or eyes)
- Difficulty urinating
- Bloody urine
- Blistering, peeling, or a purple skin rash (e.g., Stevens-Johnson Syndrome)
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You have a history of liver, kidney, or heart conditions.
- You have high blood pressure, asthma, or any bleeding disorders.
- You have a history of stomach ulcers, acidity, or inflammatory bowel disease (like Crohn's disease).
- You are scheduled for any surgery, including dental surgery.
Directions for Use
- The standard dose of Zerodol-SP tablet is one tablet. Take it once or twice a day as prescribed by your doctor.
- Always take this medicine with food and a full glass of water. This is crucial for protecting your stomach lining from irritation.
- Swallow the tablet whole. Do not crush, chew, or break it, as this can affect how the medicine is released into your body.
- Maintain a consistent time gap between doses as advised by your doctor.
- Use this medicine for the shortest duration necessary to control your symptoms. Do not use it for long-term pain without medical supervision.
Storage and disposal
- Store Zerodol-SP tablets in a cool, dry place at room temperature (below 30°C).
- Keep the medicine in its original strip or container to protect it from direct sunlight and moisture.
- Always ensure the tablets are stored out of the reach and sight of children and pets.
- Do not use the tablets after the expiry date printed on the packaging.
- Dispose of any expired or unused medicine responsibly.
Quick Tips
- Always take Zerodol-SP tablet with a meal or a glass of milk to prevent stomach upset and reduce the risk of ulcers.
- Never take Zerodol-SP with other painkillers containing paracetamol or other NSAIDs (like Ibuprofen), as this can lead to an overdose and serious side effects.
- Avoid drinking alcohol while on Zerodol-SP tablet to protect your stomach and liver.
- Zerodol-SP is very effective for toothaches, but it only treats the symptoms, not the underlying cause. You should see a dentist to address the underlying dental issue.
- If you are taking this medicine for more than a few days, your doctor may want to monitor your kidney and liver function.
Dosage
Overdose
Missed a Dose
Mode of Action
How Does It Work?
- The Zerodol-SP tablet works by combining three powerful ingredients to fight pain and swelling from multiple angles. It doesn't just mask the pain, but actively addresses the root cause for faster relief and healing....
- Aceclofenac is a key anti-inflammatory ingredient. It works by blocking certain chemicals in your body that are responsible for creating pain and inflammation signals. By stopping these "pain messengers" at their source, Aceclofenac effectively reduces the redness, warmth, and swelling associated with injuries or conditions like arthritis....
- Paracetamol is a trusted pain reliever that works mainly in your brain. While Aceclofenac fights pain at the site of the injury, Paracetamol blocks the pain signals from reaching your brain, which lowers your perception of pain. This dual-action approach provides more comprehensive pain relief and is also very effective at reducing fever....
- Serratiopeptidase is a unique enzyme that helps clean up the mess left behind by an injury. When tissues are damaged, your body can produce a lot of protein debris that causes swelling. Serratiopeptidase breaks down this debris, allowing the trapped fluid to drain away and reducing the pressure and swelling. This speeds up the entire healing process....
- Together, these three ingredients provide powerful relief by blocking pain signals, reducing inflammation, and actively cleaning up the debris that causes swelling.
Interactions
Interactions with other medicines
- Taking Zerodol-SP tablet with other painkillers like ibuprofen and aspirin is a bad idea. It can greatly increase your chances of getting stomach ulcers or internal bleeding.
- Zerodol-SP with blood thinners like warfarin can seriously increase your risk of bleeding.
- Combining Zerodol-SP with oral steroids can also increase your risk of getting stomach ulcers.
- Zerodol-SP can interfere with your blood pressure medication, reducing its effectiveness.
- Taking Zerodol-SP with certain immune-suppressing drugs (like Ciclosporin and Tacrolimus) can cause kidney damage.
- Combining Zerodol-SP with certain antibiotics (like Levofloxacin and Ciprofloxacin) can dramatically increase your risk of having fits or seizures.
- Interaction with Alcohol: Combining alcohol with Zerodol-SP is very risky and significantly increases the chance of stomach bleeding and liver damage.
Content Details

Dr. Arpit Verma
MBBS, MD, CCEBDM Diabetology

Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: What are the primary Zerodol-SP tablet uses?
Q: Is Zerodol-SP a painkiller?
Q: How effective is Zerodol-SP for tooth pain?
Q: What is the Zerodol-SP composition?
Q: What are the most common Zerodol-SP side effects?
Q: Can I take two Zerodol-SP tablets for severe pain?
Q: How long does it take for Zerodol-SP to work?
Q: Is Zerodol-SP an antibiotic?
Q: Can I use Zerodol-SP for a simple headache?
Q: What is the approximate Zerodol-SP price in India?
References
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