What special precautions should I follow?

Probenecid

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Molecule Description

Probenecid is a uricosuric agent that helps the body to pass uric acid via urine, which in turn lowers the level of uric acid in blood.

Uses

High uric acid levels (gout and gouty arthritis)
To prolong the action duration of some antibiotics like Penicillin

Contraindications

When should one not use Probenecid

Allergy to this medicine
Children below two years of age
Kidney failure
Severe dehydration
Blood disorders
Kidney stones

Side effects

Common side effects of this drug are:

Headache
Joint pain
Nausea
Vomiting
Loss of appetite
Itching and rashes
Hair fall
Increased desire to pass urine
Anaemia
Unsteadiness
Pain in the abdominal area
Blood in urine
Severe side effects include liver and kidney disorders

Precautions and Warnings

Pregnancy

Consult your doctor while taking this medicine if you are pregnant or planning a pregnancy. This medicine may cause harm to the baby and thus the benefits need to outweigh the risks.

Breast Feeding

You should consult a doctor if you are a breastfeeding mother.

Driving

This medicine may affect your alertness. Drive only if you feel comfortable.

Alcohol

Limited intake of alcohol is advised while taking this medication. It may raise the level of uric acid in blood.

Other General Warnings

Talk to your doctor if

Tell your doctor if-
You observe any signs of allergy – rashes, hives, swelling on face, etc. after taking this medicine
You have stomach ulcers
You find blood in urine
Your pain of arthritis worsens after taking this medicine
You are suffering from any medical condition
You are taking any medication (your doctor might adjust the doses of certain medicines when taking along with Probenecid)

Mode of Action

How Does It Work?

It acts on the kidneys and increases the excretion of uric acid from the body by preventing its reabsorption into the blood. It thus lowers blood uric acid level.

Interactions

Interactions with other medicines

Captopril
Ketoprofen
Naproxen
Penicillins
Methotrexate and Acyclovir
Avoid Salicylate with this medicine

Interactions with food items

No information available.

Dosage

Overdose

Overdose of Probenecid includes symptoms like drowsiness, stomach upset, vomiting, convulsions, breathlessness and nausea. Immediately contact a healthcare provider if an overdose is suspected.

Missed a Dose

If you have missed the Probenecid regular dose, then take the missed dose as soon as you remember it. If it is almost time for the next dose, then skip the missed dose and continue with the subsequent regular dosage. Do not take a double dose.

Frequently Asked Questions (FAQs)

Probenecid may cause kidney problems, so drink plenty of water to prevent kidney stones. It also causes dizziness, so avoid driving and operating heavy machines. Patients with a history of peptic ulcers should be careful while taking this medicine.