PRIMOLUT-N TABLET

• Heavy Menstrual Bleeding (Menorrhagia): Primolut-N reduces prolonged and heavy menstrual bleeding by regulating the growth and shedding of the womb lining.
• Painful Periods (Dysmenorrhoea): Primolut-N tablet helps alleviate pain and severe cramps associated with menstruation.
• Delaying Periods: One of the most common uses of Primolut-N tablet is postponing menstruation. Most individuals use this during travel, holidays, or special events. It is essential to know that a proper Primolut-N dosage is necessary to delay menstruation. Use only under medical supervision.
• Endometriosis: Primolut-N helps manage symptoms of endometriosis (a condition where uterine tissue grows outside the womb, causing pain and irregular bleeding).
• Premenstrual Syndrome (PMS): The Primolut-N tablet can help manage severe PMS symptoms, such as bloating, breast tenderness, and mood swings.
• Irregular Periods: It helps regulate the menstrual cycle and treat infrequent or unpredictable periods.

• If you are allergic to Norethisterone or any other ingredients in the tablet, do not use.
• If you are pregnant or suspect you might be pregnant, talk to your doctor before you use the Primolut-N tablet.
• If you have a history of blood clots (thrombosis - deep vein thrombosis or pulmonary embolism) in your legs, lungs, or other organs, or a history of jaundice or skin allergies such as pruritus.
• If you have a history of breast, genital or hormone-dependent cancer.
• If you have or have had a heart attack, stroke, or severe liver disease.
• If you have unexplained vaginal bleeding that a doctor has not diagnosed.
• If you have a history of jaundice or severe itching during a previous pregnancy.
• If you are experiencing vaginal bleeding that has not yet been diagnosed.
• If you are suffering from disorders of lipid metabolism or have abnormal cholesterol levels.

• Headache or migraine
• Nausea (feeling sick)
• Breast tenderness
• Mood changes or dizziness
• Vaginal bleeding or spotting between periods
• Absence of periods (amenorrhoea)

• Sudden severe pain and swelling in a leg
• Sharp chest pain
• Coughing up blood
• Jaundice (yellowing of the skin or eyes)
• A significant rise in blood pressure
• Sudden changes in vision or hearing

Other General Warnings

• You are pregnant, think you might be pregnant, or are currently breastfeeding, as Primolut-N is not considered safe in these situations.
• You have any history of heart problems, high blood pressure, stroke, high cholesterol, or blood clots (like deep vein thrombosis).
• You suffer from any liver or kidney disease, have a history of gallstones, or have ever experienced jaundice (yellowing of the skin or eyes).
• You have unexplained vaginal bleeding that has not been diagnosed, or you have a history of hormone-dependent cancers (like breast or genital cancer).
• You suffer from diabetes or porphyria (a rare inherited blood disease), as the Primolut-N tablet can affect these conditions.
• You experience severe or frequent migraines, suffer from epilepsy, asthma, or multiple sclerosis (MS).
• You are scheduled for surgery, and your doctor may advise you to stop taking Primolut-N four weeks before the procedure to minimise health risks.
• You are a smoker, especially if you are over the age of 35, as this can increase the risk of side effects.
• You have a known allergy to Norethisterone or any other ingredients listed in the Primolut-N tablet.
• You develop new or worsening headaches, sudden vision changes, or a significant rise in blood pressure while taking the medication.

• It is essential to note that the Primolut-N dosage varies depending on the condition being treated. So, always follow your doctor's prescription.
• Swallow the prescribed Primolut-N tablet whole with a full glass of water.
• It is advised to take the tablet either with or without food.
• To delay periods, take one Primolut-N tablet three times a day, starting 3 days before your expected period.
• You can continue taking Primolut-n tablet for as long as you wish to delay periods (up to a maximum of 14 days).
• Once you stop taking the tablet, your periods will resume within 2-3 days.
• For other conditions, such as heavy bleeding, the dose of Primolut-N and its duration may vary.

• Store Primolut-N tablets at room temperature, between 15 °C and 30°C.
• Keep them in the original pack to protect them from direct sunlight and moisture.
• Keep all medicines out of the reach of children and pets.
• Do not use the tablets after the expiry date printed on the pack.

• Primolut-N is NOT a birth control pill. You must use a non-hormonal contraceptive, like condoms, to prevent pregnancy while taking it.
• Always take the exact dosage prescribed by your doctor and never take more than recommended to avoid increasing the risk of side effects.
• This medicine is intended for short-term use, especially for delaying periods, and should not be used long-term without your doctor's approval.
• Before starting, inform your doctor about your complete medical history (especially diabetes or depression) and any other medicines or supplements you are taking.
• Do not take Primolut-N if you are breastfeeding, as the hormone can pass into your breast milk and may affect your baby.
• If you experience frequent or heavy spotting between periods while taking the tablet, be sure to let your doctor know.
• When using the tablet to postpone your period, make sure to start taking it a few days before your period is due, exactly as instructed by your doctor.

Overdose

Missed a Dose

How Does It Work?

• The active ingredient in Primolut N is Norethisterone, a man-made version of the female hormone progesterone. In a natural menstrual cycle, a drop in progesterone levels signals the breakdown and shedding of the womb lining, resulting in menstruation. Primolut N works by artificially maintaining high levels of this progesterone-like hormone in your body.
• This effectively tricks your system into maintaining the uterine lining instead of shedding it. By preventing the breakdown of this lining, the medication can successfully postpone the start of a period for a desired length of time. This same mechanism also provides stability to the uterine lining, which is why it is an effective treatment for managing conditions such as heavy, painful, or irregular menstrual bleeding. Mimicking the body's own hormonal signals helps to regulate the entire menstrual process, offering control and relief from various gynaecological issues.

Interactions with other drugs

Interactions with food items

• You can take Primolut-N Tablet with or without food, but taking it after a meal may help prevent nausea or stomach discomfort.
• Avoid drinking alcohol in excess, as it can worsen side effects like dizziness or headache.
• Limit foods high in saturated fats and sugar to maintain hormonal balance and overall health.
• Eat a balanced diet rich in fruits, vegetables, and whole grains to support your body while on hormonal treatment.
• Drink plenty of water throughout the day to stay hydrated and reduce bloating or water retention.
• Avoid consuming grapefruit or grapefruit juice while taking this medicine, as it may interfere with how your body processes the hormone.
• If you are prone to nausea, eat small, frequent meals rather than large ones.
• Do not skip meals, as it can cause hormonal fluctuations and affect the medicine’s effectiveness.
• Avoid caffeine in excess, as it can worsen symptoms like anxiety or restlessness that sometimes occur with hormonal medicines.