Methotrexate

Molecule Description

Methotrexate is a medicine which kills cells in tumors, cancers and also suppre

sses the immune system.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Methotrexate

To treat psoriasis
To treat rheumatoid arthritis
To treat various types of cancers such as breast and lung cancers
Also used as a single agent or in combination with anti-cancer medications

Contraindications of Methotrexate

When should one not use Methotrexate

Allergic reaction to this medicine
Pregnancy and breastfeeding
Severe liver or kidney disease
Decreased platelets and white blood cells
If you have recently received a live vaccine
If you have ulcers in the mouth
If you have fever, joint pain

Side effects of Methotrexate

Common side effects of this drug are:

Diarrhea
Mouth ulcers
Weakness
Menstrual problems
Skin rash
Persistent cough
Joint pain, muscle pain
Stomach pain
Swelling of feet
Dizziness
Yellowing of the skin (liver damage)
Fever with chills
Unusual bleeding
Blurred vision
Temporary hair Loss
Loss of appetite
Difficulty in passing urine
Nausea or vomiting
Decrease white blood cells

Precautions and Warnings of Methotrexate

Pregnancy

Can I take Methotrexate during pregnancy?

It is highly unsafe to use during pregnancy. Human and animal studies have shown significant side effects on fetus like birth defects or miscarriage. If you are a woman of childbearing age, strictly use contraception and avoid pregnancy.

Breast Feeding

Can I take Methotrexate while breastfeeding?

Methotrexate is strictly not to be taken during breastfeeding.

Driving

Can I drive if I have consumed Methotrexate?

Do not drive until your vision is clear. It may cause dizziness, drowsiness.

Alcohol

Can I consume alcohol with Methotrexate?

Alcohol should be avoided while receiving Methotrexate as it increases the chances of damaging your liver.

Other General Warnings

Talk to your doctor if

You have kidney disease, ulcers in the stomach, diabetes mellitus or any infections
You have received any live vaccines
You should avoid having a baby at least 6 months after stopping Methotrexate as this medicine affects sperm and egg production
If you experience cough with blood or pink color sputum immediately inform your doctor
Taking more medicine than what is prescribed by your doctor can be very harmful and should be avoided
If you are on this medicine for the long term, regular health check-ups are required

Mode of Action of Methotrexate

How Does It Work?

It works by stopping or slowing down the growth of cancer cells and suppress the immune system. In rheumatoid arthritis, it works by decreasing the activity of the body's immune system. This decrease ...

Interactions of Methotrexate

Interactions with other medicines

Using Methotrexate with individual Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as Ibuprofen, Aceclofenac, Acemetacin and Diclofenac can cause severe and sometimes fatal bone marrow suppression...
Read more
When used along with radiotherapy, Methotrexate may increase the risk of cell death in soft tissues and bones
Live vaccines
Cyclosporin’s (used in transplantation)

Interactions with food items

No information is available on interactions of Methotrexate when taken with food, consult your doctor or pharmacist for further details.

Dietary Restrictions of Methotrexate

No information is available on dietary restrictions while you are taking Methotrexate, consult your doctor or pharmacist for further information.

Dosage of Methotrexate

Overdose

In overdose, vomiting, diarrhea and gastrointestinal bleeding may occur. Severe bone marrow suppression may occur. Liver toxicity is more likely in patients with pre-existing risk factors for liver di...

Missed a Dose

If you missed any dose, take it as soon as you remember. Skip the missed dose if it is time for your next dose. Do not take an extra dose of medicine to make up the missed dose. Be very careful with t...

Content Details

WRITTEN BY

Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: What precautions should I take before treatment with Methotrexate?

A: Prolonged use of Methotrexate may cause liver damage, including cirrhosis (irreversible scarring of the liver), which may be fatal. High doses of Methotrexate can also damage the kidneys and cause kidney failure. People with psoriasis or rheumatoid arthritis may not be suitable for Methotrexate if they have alcoholism, alcoholic liver disease or other chronic liver diseases, have an immunodeficiency syndrome, have a blood deficiency disorder such as anemia (low red blood cell count), leukopenia (low white blood count) or thrombocytopenia (low blood platelet count).

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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