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Duvanta Np 40mg Tablets

10 Tablet(s) in Strip
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Duvanta Np 40mg Tablets Description

Duvanta NP is a prescription medication. It is used in the management of neuropathic pain (pain that occurs as a result of nerve damage). The active components of Duvanta NP are Duloxetine (40mg) and

Methylcobalamin (1500mcg). Neuropathic pain essentially refers to pain that is a consequence of damage to nerves. This is commonly seen associated with conditions like Diabetes Mellitus, infections like leprosy, herpes, HIV, Post-stroke pain, etc. These disease processes result in damage to peripheral nerves and along the pathways of touch and pain signal transmission to and from the brain. Neuropathic pain is distinct in its presentation; patients typically present with burning sensation, electric-shock like sensations, and pain in response to non-painful stimuli like a soft touch. The symptoms of neuropathic pain often persist chronically and can be debilitating to patients. It can result in sleep disturbance, depression, and anxiety as well. Neuropathic pain is a frequent cause of repeat hospital visitations. Duvanta NP is a combination of Duloxetine which works on chemical messengers along the nerve pathways to decrease the perception of pain, and Methylcobalamin, which is a neuro-protective agent. This medication is especially effective in the management of diabetic peripheral neuropathic pain. Take this medication as prescribed by your treating doctor. Taking the tablet at the same time every day is advisable for maximum efficacy. Do not abruptly stop this medication without consulting your doctor.


Product Summary

Offer Price₹164.65
You Save₹20.35 (11% on MRP)
ContainsDuloxetine + Mecobalamin [Vit B12]
UsesTreatment of neuropathic pain (diabetic neuropathic pain)
Side effectsnausea, dry mouth, somnolence, fatigue, constipation, decreased appetite, and hyperhidrosis
Check more medicines with composition as Duloxetine + Mecobalamin [Vit B12]

Uses of Duvanta Np 40mg Tablets

  • As per CDSCO regulations, Duvanta NP is used in the treatment of Neuropathic Pain (Diabetic Peripheral Neuropathic Pain)

Contraindications of Duvanta Np 40mg Tablets

  • Hypersensitivity reactions – avoid using this medication in case of hypersensitivity reactions to this medication/ inactive ingredients.
  • This medication should not be used in patients with liver impairment.
  • It is contraindicated in patients with kidney failure.
  • It is contraindicated in patients with angle-closure glaucoma.
  • This medication should not be used in patients with any known seizure disorder.
  • It is contraindicated in patients with elevated blood pressure, not on treatment (uncontrolled hypertension), as it can result in a hypertensive crisis.
  • It is contraindicated in patients with urinary retention and hesitation.
  • This medication should not be used in patients with a history or family history of mania or bipolar disorder, as it may result in activation of mania.
  • There is an FDA black box warning for an increase in suicidal ideation when used in children, adolescents, and young adults <24 years of age.
  • This medication is not approved for use in the paediatric age group.

Side effects of Duvanta Np 40mg Tablets

  • Nausea
  • Dry Mouth
  • Somnolence (increased sleepiness)
  • Fatigue
  • Constipation
  • Decreased Appetite
  • Increased sweating (hyperhidrosis)
  • Headache
  • Drowsiness
  • Dizziness
  • Sexual dysfunction

Precautions and Warnings of Duvanta Np 40mg Tablets



Can I take Duvanta NP during pregnancy?
No, Duloxetine is a category C medication and is unsafe during pregnancy. It should not be taken while pregnant or while intending to conceive. Consult your doctor, and inform them regarding your health status.

Breast Feeding

Can I take Duvanta NP while breastfeeding?
This medication is generally not advised while breastfeeding, as it is secreted in breast milk and can cause harm to the infant. Discuss your breastfeeding status with your doctor for more information.


Can I drive if I have taken Duvanta NP?
Driving and operating other heavy machinery while on this medication is not recommended as it may cause somnolence and drowsiness.


Can I consume alcohol with the Duvanta NP?
It is contraindicated to mix alcohol with this medication as it causes increased sedation and other adverse effects.

Other General Warnings

Talk to your doctor if
  • Inform your doctor about any other medications you are taking. This tablet interacts with many other medications that use the same metabolic enzymes.
  • You should report to your doctor immediately in case of any discomfort or sudden mood changes.

Mode of Action of Duvanta Np 40mg Tablets

How Does It Work?

One of the hypotheses for neuropathic pain involves a deficiency of the chemical messengers (neurotransmitters) Norepinephrine and Serotonin along pain transmission pathways. The deficiency is thought...
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Directions for Use of Duvanta Np 40mg Tablets

  • This medication should be taken as prescribed by your doctor.
  • Take this medication on a regular schedule, i.e., at the same time every day, for best effects.
  • Swallow this medication as a whole with a glass of water. Do not crush, chew or break this tablet.
  • It is recommended to finish the full course of this medication as prescribed by your treating doctor.
  • It may take up to 2-3 weeks of continued use for this medication to see results.
  • Abrupt stoppage of the medicine can cause withdrawal side effects. Consult your doctor before stopping this medication.

Interactions of Duvanta Np 40mg Tablets

Interactions with other medicines

  • This medication should not be used concomitantly with MAOIs (Monoamine oxidase inhibitors) or within 14 days of the use of MAOIs and vice versa. Examples of MAOIs include Selegiline, Rasagiline.
  • This is because it can result in a life-threatening condition called Serotonin Syndrome.
  • It should also not be used alongside other medications that can cause an increase in Serotonin levels, like anti-depressants, linezolid, triptans, and opioids.
  • It should not be mixed with medications that cause the arrest of bleeding, such as aspirin, NSAIDs, heparin, warfarin, and other anticoagulants. This is because Duloxetine itself causes an increased r...
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  • This medication should not be mixed with alcohol, opioids, or any other CNS involving medications.
  • It should not be used with medications that are potent inhibitors of the enzymes that metabolise Duloxetine.
  • Inform your doctor regarding your regular medications at the time of prescription of Duvanta NP.

Interactions with food items

  • This medication does not have any known interaction with food.

Storage and disposal of Duvanta Np 40mg Tablets

Store in a cool, dry place. Keep the tablet away from direct light and moisture. Keep tablets away from the reach of children and pets. Do not flush this medication down the toilet. Dispose of it as b...
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Dosage of Duvanta Np 40mg Tablets


  • Signs and symptoms of overdose of Duloxetine include vomiting, rise or fall of blood pressure, increase in heart rate, transient loss of consciousness, somnolence, seizures, coma, and serotonin syndro...
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  • In case of a suspected overdose, rush the patient to a tertiary care centre with ICU facilities for further evaluation and treatment.

Missed a Dose

If you miss a dose of Duvanta NP, take the tablet as soon as you remember. If the duration lapsed is long, and it is almost time for the next dose, skip the missed dose and return to your regular sche...
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Content Details


Dr. Bhavika Shah

MBBS, MD (Dermatology), DNB (Dermatology)

Frequently Asked Questions (FAQs)


Q: I have been using this medicine for a few days but feel no change. What should I do?

A: Duvanta NP can take up to 2-3 weeks for the full effects of the tablet to manifest. Talk to your doctor for more information.

Q: I have been having issues with intercourse since starting this medication. What should I do?

A: Duvanta NP can cause sexual dysfunction, including decreased sexual desire and erectile dysfunction. Talk to your doctor for more information. Your doctor will be able to guide you and help you manage any side effects you may be experiencing.

Q: I have been prescribed a course of painkillers for a knee injury. Can I take it with this tablet?

A: Certain painkillers might cause side effects when taken with Duvanta NP, such as an increased chance of bleeding. It is always advisable to inform your doctor about any medications you are on at the time of prescription.
Product Details
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Last Updated on: 04 Jun 2022 | 06:16 PM (IST)

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