Duvanta Np 40Mg Strip Of 10 Tablets
10 Tablet(s) in StripWe do not sell this product
Made by
INTAS PHARMACEUTICALS LTD
Dosage
TABLET
Expiry
Product Summary
| Salt Content | Duloxetine+Mecobalamin [Vit B12] |
| Uses | Treatment of neuropathic pain (diabetic neuropathic pain) |
| Therapy | Drugs for peripheral neuropathy |
| Side effects | nausea, dry mouth, somnolence, fatigue, constipation, decreased appetite, and hyperhidrosis |
Assurance
available
Regulated
Medical Description
Duvanta NP is a prescription medication. It is used in the management of neuropathic pain (pain that occurs as a result of nerve damage). The active components of Duvanta NP are Duloxetine (40mg) and Methylcobalamin (1500mcg).
Neuropathic pain essentially refers to pain that is a consequence of damage to nerves. This is commonly seen associated with conditions like Diabetes Mellitus, infections like leprosy, herpes, HIV, Post-stroke pain, etc. These disease processes result in damage to peripheral nerves and along the pathways of touch and pain signal transmission to and from the brain.
Neuropathic pain is distinct in its presentation; patients typically present with burning sensation, electric-shock like sensations, and pain in response to non-painful stimuli like a soft touch. The symptoms of neuropathic pain often persist chronically and can be debilitating to patients. It can result in sleep disturbance, depression, and anxiety as well. Neuropathic pain is a frequent cause of repeat hospital visitations.
Duvanta NP is a combination of Duloxetine which works on chemical messengers along the nerve pathways to decrease the perception of pain, and Methylcobalamin, which is a neuro-protective agent. This medication is especially effective in the management of diabetic peripheral neuropathic pain.
Take this medication as prescribed by your treating doctor. Taking the tablet at the same time every day is advisable for maximum efficacy. Do not abruptly stop this medication without consulting your doctor.
Uses
- As per CDSCO regulations, Duvanta NP is used in the treatment of Neuropathic Pain (Diabetic Peripheral Neuropathic Pain)
Contraindications
- Hypersensitivity reactions – avoid using this medication in case of hypersensitivity reactions to this medication/ inactive ingredients.
- This medication should not be used in patients with liver impairment.
- It is contraindicated in patients with kidney failure.
- It is contraindicated in patients with angle-closure glaucoma.
- This medication should not be used in patients with any known seizure disorder.
- It is contraindicated in patients with elevated blood pressure, not on treatment (uncontrolled hypertension), as it can result in a hypertensive crisis.
- It is contraindicated in patients with urinary retention and hesitation.
- This medication should not be used in patients with a history or family history of mania or bipolar disorder, as it may result in activation of mania.
- There is an FDA black box warning for an increase in suicidal ideation when used in children, adolescents, and young adults <24 years of age.
- This medication is not approved for use in the paediatric age group.
Side effects
- Nausea
- Dry Mouth
- Somnolence (increased sleepiness)
- Fatigue
- Constipation
- Decreased Appetite
- Increased sweating (hyperhidrosis)
- Headache
- Drowsiness
- Dizziness
- Sexual dysfunction
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- Inform your doctor about any other medications you are taking. This tablet interacts with many other medications that use the same metabolic enzymes.
- You should report to your doctor immediately in case of any discomfort or sudden mood changes.
Directions for Use
- This medication should be taken as prescribed by your doctor.
- Take this medication on a regular schedule, i.e., at the same time every day, for best effects.
- Swallow this medication as a whole with a glass of water. Do not crush, chew or break this tablet.
- It is recommended to finish the full course of this medication as prescribed by your treating doctor.
- It may take up to 2-3 weeks of continued use for this medication to see results.
- Abrupt stoppage of the medicine can cause withdrawal side effects. Consult your doctor before stopping this medication.
Storage and disposal
Store in a cool, dry place. Keep the tablet away from direct light and moisture. Keep tablets away from the reach of children and pets. Do not flush this medication down the toilet. Dispose of it as biomedical waste appropriately.
Dosage
Overdose
- Signs and symptoms of overdose of Duloxetine include vomiting, rise or fall of blood pressure, increase in heart rate, transient loss of consciousness, somnolence, seizures, coma, and serotonin syndrome.
- In case of a suspected overdose, rush the patient to a tertiary care centre with ICU facilities for further evaluation and treatment.
Missed a Dose
If you miss a dose of Duvanta NP, take the tablet as soon as you remember. If the duration lapsed is long, and it is almost time for the next dose, skip the missed dose and return to your regular schedule. Do not double the dose of this medication.
Mode of Action
How Does It Work?
One of the hypotheses for neuropathic pain involves a deficiency of the chemical messengers (neurotransmitters) Norepinephrine and Serotonin along pain transmission pathways. The deficiency is thought to produce an increased perception of pain by the brain. Duloxetine is a Serotonin and Norepinephrine Reuptake Inhibitor (SNRI). It prevents the reabsorption of these neurotransmitters by the nerve cells, resulting in their accumulation. This decreases the brain’s perception of pain. In addition, Duloxetine also causes an increase in dopamine levels. These effects of Duloxetine also help in decreasing symptoms of depression and anxiety, thereby improving the patient’s overall mood.
Methylcobalamin is an active form of Vitamin B12. It helps in the formation of myelin, which is a substance that is present covering nerve cells. Studies have shown that Methylcobalamin has pain-relieving effects. It produces these effects by increasing the ability of nerve cells to transmit signals and by regenerating damaged nerve cells.
Interactions
Interactions with other medicines
- This medication should not be used concomitantly with MAOIs (Monoamine oxidase inhibitors) or within 14 days of the use of MAOIs and vice versa. Examples of MAOIs include Selegiline, Rasagiline.
- This is because it can result in a life-threatening condition called Serotonin Syndrome.
- It should also not be used alongside other medications that can cause an increase in Serotonin levels, like anti-depressants, linezolid, triptans, and opioids.
- It should not be mixed with medications that cause the arrest of bleeding, such as aspirin, NSAIDs, heparin, warfarin, and other anticoagulants. This is because Duloxetine itself causes an increased risk of bleeding.
- This medication should not be mixed with alcohol, opioids, or any other CNS involving medications.
- It should not be used with medications that are potent inhibitors of the enzymes that metabolise Duloxetine.
- Inform your doctor regarding your regular medications at the time of prescription of Duvanta NP.
Interactions with food items
- This medication does not have any known interaction with food.
Frequently Asked Questions (FAQs)
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Manufacturer Details
Brand:DUVANTA NP
Manufacturer Name:INTAS PHARMACEUTICALS LTD
Address:<p>1. Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.</p>
Country of Origin:India
Vendor Details
Fulfillment Information: Duvanta Np 40mg Strip Of 10 Tablets will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.
References:
- Cymbalta (duloxetine hydrochloride).
- Dhaliwal JS, Spurling BC, Molla M. Duloxetine. [Updated 2021 Jun 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.
- Colloca, L., Ludman, T., Bouhassira, D., Baron, R., Dickenson, A. H., Yarnitsky, D., Freeman, R., Truini, A., Attal, N., Finnerup, N. B., Eccleston, C., Kalso, E., Bennett, D. L., Dworkin, R. H., & Raja, S. N. (2017). Neuropathic pain. Nature reviews. Disease primers, 3, 17002
- Sharma, C., Kaur, I., Singh, H., Grover, I. S., & Singh, J. (2021). A randomised comparative study of methylcobalamin, methylcobalamin plus pregabalin and methylcobalamin plus duloxetine in patients of painful diabetic neuropathy. Indian journal of pharmacology, 53(5), 358–363.
- Cymbalta 30mg hard gastro-resistant capsules - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [cited 18 March 2022].
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