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Depsol 75mg Tablet

10 Tablet(s) in Strip
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Depsol 75 MG Description

Depsol tablet is used to treat major depressive disorders. It can also be used to treat nocturnal enuresis (bedwetting at night) in children six years and older. Major depressive disorder or depressi

n is a mood disorder characterised by sadness, loss of interest, mood swings, hopelessness and loneliness. Depsol tablet contains Imipramine as the active ingredient. Imipramine is an antidepressant that regulates the chemical messenger called Serotonin and norepinephrine. These chemical messengers are responsible for balancing mood and behaviour. The patient should take Depsol tablet dosage as per the doctor’s prescription. The patient should not take the medicine without consulting a doctor as there are many side effects associated with this medicine. Sudden discontinuation of Depsol tablets may cause clinical worsening of your condition or result in withdrawal symptoms.

Product Summary

Offer Price₹26.77
You Save₹4.73 (15% on MRP)
ContainsImipramine(75.0 Mg)
UsesTreatment of major depressive disorder (MDD), Nocturnal enuresis (bedwetting)
Side effectsDrowsiness, Headache, Nausea, Vomiting, Dry mouth, Diarrhoea or constipation, Increased sweating
Check more medicines with composition as Imipramine(75.0 Mg)

Uses of Depsol 75 MG

  • As per CDSCO and USFDA, Depsol tablet is used for the following conditions:
  • Treatment of major depressive disorder (MDD)
  • Treatment of nocturnal enuresis

Contraindications of Depsol 75 MG

  • Depsol tablets are contraindicated in the following cases:
  • If you are allergic to a component of the Depsol tablet, i.e. Imipramine
  • If you are already taking antidepressants, anti-anxiety or sedative medications
  • If you are taking narcotic or opioid pain relievers
  • If you have acute angle glaucoma, which increases the fluid pressure in the eyes
  • If you notice suicidal thoughts or ideation
  • If you have respiratory depression
  • If you have a history of seizure disorder and are currently under treatment for it
  • If you have a history of brain damage or a head injury
  • If you have liver and kidney disease
  • If you are pregnant
  • If you are a breastfeeding mother

Side effects of Depsol 75 MG

  • The side effects of Depsol tablets include the following:
  • Drowsiness
  • Headache
  • Nausea
  • Vomiting
  • Dry mouth
  • Diarrhoea or constipation
  • Increased sweating

Precautions and Warnings of Depsol 75 MG


Can I take a Depsol tablet during pregnancy?
Depsol tablet is unsafe during pregnancy. Pregnant women should take Depsol tablet only if necessary or in some life-threatening condition. Pregnant women should consult a doctor before taking this medicine and inform their doctor about their pregnancy or intention to conceive at the time of prescription.

Breast Feeding

Can I take a Depsol tablet while breastfeeding?
Do not take Depsol tablet during breastfeeding. Some clinical data indicates that this medicine may pass into breastmilk and should be used with caution in breastfeeding women. Even a tinyl amount of this medicine in breast milk is sufficient to cause withdrawal symptoms in breastfed infants.


Can I drive if I have taken the Depsol tablet?
Depsol tablet may cause side effects that could affect your ability to drive. The tablet may cause decreased alertness, sedation, blurred vision, mental confusion, nausea and can cause dizziness, lethargy, lightheadedness. Avoid driving if you are experiencing these side effects after taking the Depsol tablet.


Can I consume alcohol with the Depsol tablet?
Alcohol consumption with Depsol tablet is not advised. It increases the severity of side effects like decreased vision, dizziness, drowsiness, sedation, liver injury, etc. It can also worsen the condition of your disease.

Other General Warnings

Talk to your doctor if
  • You have any allergic reactions after taking the Depsol tablet.
  • You notice any sudden self-harming thoughts or suicidal ideation.
  • You have trouble breathing or talking.
  • You experience any severe side effects persistently.
  • You have mild or severe liver and kidney disease; this medicine may need a dose adjustment.
  • You are pregnant or planning a pregnancy during treatment.
  • You are using oral contraceptives.
  • You are using any ayurvedic medicines, vitamins, and other health supplements.

Mode of Action of Depsol 75 MG

How Does It Work?

Depsol tablet contains Imipramine-75mg as an active ingredient. Imipramine belongs to the tricyclic antidepressant class of medicine. It works by inhibiting the reuptake (reabsorption) of chemical mes...
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Directions for Use of Depsol 75 MG

  • Take a Depsol tablet as prescribed by the doctor.
  • Take the medicine with or without food or as prescribed.
  • Take Depsol tablet on a regular schedule, preferably at the same time every day.
  • Consume the whole tablet orally with a glass of water. Do not chew or break this tablet.
  • Do not take Depsol tablet with other medications without consulting your doctor.
  • Do not stop taking Depsol tablet abruptly, as it may lead to withdrawal symptoms.
  • Do not exceed the dosage of Depsol tablet on your own, even if you cannot feel its effects.

Interactions of Depsol 75 MG

Interactions with other medicines

  • Concomitant use of Depsol tablet with other CNS depressants and opioids is strictly contraindicated, as it may cause respiratory depression, coma and death.
  • Depsol tablets should not be used concomitantly or within two weeks of using Monoamine oxidase inhibitors (MAOIs) like isocarboxazid, linezolid, methylene blue, Selegiline, Rasagiline, etc. It is pote...
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  • Depsol tablet interaction with an antidepressant, antihistamines (allergy medicines), pain killers, such as morphine, oxycodone, fentanyl, hydrocodone, tramadol, codeine, sleeping pills, etc., can inc...
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  • Depsol tablets can interact with birth control pills, or oral contraceptives can reduce effectiveness. So it is advised to use other methods of contraception like condoms.
  • Depsol tablet interaction with Herbal products like St John’s wort can lead to life-threatening side effects.

Interactions with food items

  • Avoid consuming Tyramine-rich foods such as cheese, milk, meat, chocolate, chicken liver, grapefruit juice, etc., while taking Depsol tablet.

Storage and disposal of Depsol 75 MG

Store Depsol tablet at room temperature in a cool and dry area, away from direct sunlight. Keep the medication away from the reach of children and pets. Do not remove the medicine from its original pa...
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Dosage of Depsol 75 MG


Depsol tablet overdose symptoms may include fainting, somnolence, impairment of motor functions, including dizziness, poor coordination, muscle weakness, loss of balance, low blood pressure (hypotensi...
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Missed a Dose

If you miss a dose of Depsol tablet, take it as soon as possible. If the duration missed is too long, and it is almost time for the next dose, skip the missed dose and go back to the regular schedule...
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Content Details


Dr. Zishan Ahmad

Final year MBBS Student


Dr. Varsha Parihar

MBBS, MD (Community Medicine)

Frequently Asked Questions (FAQs)


Q: How much time does the Depsol tablet take to show its desired effect?

A: Depsol tablets usually take between 4 to 6 weeks before you see improvement in your symptoms. Once you feel better, you are advised to continually take this medicine for several more months to prevent the symptoms from returning and properly follow the doctor's advice.

Q: Can I discontinue taking the Depsol tablet on my own after improving my symptoms?

A: Do not stop taking Depsol tablet despite having symptomatic relief. Abruptly stopping this medication can cause withdrawal symptoms which can be severe and debilitating. Consult your doctor before stopping the medication as doses need to be slowly tapered to avoid side effects.

Q: Can I gain weight while using the Depsol tablet?

A: Some data shows that consumption of Depsol tablets may lead to weight gain if it is used for a longer duration. However, it varies from person to person and disease condition. If you notice any weights changes, be more active, exercise regularly and eat healthily.
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Last Updated on: 24 Mar 2022 | 09:41 PM (IST)

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