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Pentothal Sodium 1gm Dry Vial Of 1 Powder For Injection

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1 Powder For Injection(s) in Dry Vial

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Description

Pentothal Sodium Injection is used for general anaesthesia. It can be used to lower intracranial pressure as well. Pentothal Sodium 1gm Injections are given under the supervision of a healthcare pra

ctitioner in a hospital setting. It's crucial to share your medical history and let your doctor know if you have heart disease, asthma, or myasthenia gravis. This medication requires extra caution when administered to these people. Side effects of Pentothal Sodium 1gm Injection include skin rash or pain at the injection site and nausea, vomiting, diarrhoea, and vertigo. Because it may produce dizziness and fatigue, do not drive or do anything that requires mental focus while taking it. You should avoid drinking alcohol or taking other sleepy drugs after taking this prescription since it may cause serious side effects. You should utilise additional pregnancy prevention strategies because this medication may diminish the effectiveness of birth control tablets.

Product Summary

Offer Price	₹34.96
You Save	₹11.04 (24% on MRP)
Contains	Thiopentone / Thiopental / Penthiobarbital(1.0 Gm)
Uses	Anaesthesia
Side effects	Drowsiness, Skin Rash, Nausea, Vomiting, Diarrhoea, Vertigo
Therapy	GENERAL ANAESTHESIA

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Pentothal 1 GM

Anaesthesia

Contraindications of Pentothal 1 GM

Allergy
You should not use this drug if you have a known allergy to Pentothal Sodium or any other inactive ingredients in the formulation.
Respiratory depression
This injection is not recommended for patients with respiratory depression due to the increased risk of the patient's condition worsening.
Porphyria
This injection is not recommended for porphyria patients due to the higher risk of the patient's condition worsening.
Myasthenia gravis
This injection is not recommended for people with myasthenia gravis since it increases the chance of the patient's condition worsening.
Severe anaemia
This injection is not recommended for use in patients with severe anaemia due to the increased risk of the patient's condition worsening.

Side effects of Pentothal 1 GM

Drowsiness
Skin Rash
Nausea
Vomiting
Diarrhoea
Vertigo

Precautions and Warnings of Pentothal 1 GM

Pregnancy

Can I take Pentothal Sodium 1gm Injection during pregnancy?

Using injections while pregnant can be risky. Despite the absence of human studies, animal research has shown harmful effects on the developing foetus. Your doctor will weigh the benefits and any potential risks before recommending them to you. Please consult a physician.

Breast Feeding

Can I take Pentothal Sodium 1gm Injection while breastfeeding?

Pentothal Sodium 1gm Injection is safe to use when nursing. According to human research, the medicine does not pass substantial amounts into breastmilk and does not harm the baby.

Driving

Can I drive if I have taken Pentothal Sodium 1gm Injection 1'S?

Pentothal Sodium 1gm Injection may have side effects that make driving difficult.

Alcohol

Can I consume alcohol with the Pentothal Sodium 1gm Injection?

If you drink alcohol while taking Pentothal, you may experience dizziness and sleepiness (thiopental). Because both alcohol and Pentothal depress the central nervous system, the two together are significantly more dangerous; thus, avoid all alcohol use while preparing for a Pentothal injection.

Other General Warnings

Talk to your doctor if

If you have heart disease- Due to worsening the patient's condition, this medicine should be used with caution in patients with heart disease. In some situations, dependent on the clinical condition o...
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If you have thyroid disorders-Because of the danger of worsening the patient's condition, this medicine should be used with caution in patients with thyroid problems. In some situations, dependent on ...
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If you have Hypovolemia-Due to the potential of worsening the patient's condition, this medicine should be used with caution in patients with a low level of fluids in the body. In some situations, dep...
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If you have hypotension-Patients receiving this injection for anaesthesia should be continuously watched for evidence of severe hypotension (low blood pressure) or heart depression. Appropriate remedi...
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Mode of Action of Pentothal 1 GM

How Does It Work?

It works by inducing reversible loss of consciousness, allowing surgery to be performed without pain or discomfort.

Directions for Use of Pentothal 1 GM

Your doctor or nurse will administer this medication to you. Please refrain from self-medicating.

Interactions of Pentothal 1 GM

Interactions with other medicines

Gastrointestinal medicines like Metoclopramide and droperidol reduce the dose of Pentothal Sodium required to induce anaesthesia.
Using anaesthetics with other CNS depressant medicines such as those used for premedication may produce synergistic effects on the CNS. In some cases, a smaller dose of general anaesthetic should be u...
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Benzodiazepines such as midazolam potentiate the anaesthetic effects of Pentothal Sodium.
Pretreatment with probenecid has been shown to potentiate Pentothal Sodium anaesthesia.
The enhanced hypotensive effects are seen when general anaesthetics are given with angiotensin-II receptor antagonists like Eprosartan, Irbesartan, Losartan, Olmesartan, Telmisartan
Hypersensitivitylike reactions can occur when general anaesthetics are given with intravenous vancomycin.
Increased risk of arrhythmias and hypotension when general anaesthetics are given with tricyclic antidepressants. Hypotension and hypertension have been seen with MAOIs.
The enhanced hypotensive effect may be seen when Pentothal Sodium is given with diazoxide.
The enhanced hypotensive effect may be seen when Pentothal Sodium is given with diuretics.
The enhanced hypotensive effect may be seen when Pentothal Sodium is given with methyldopa.
Moxonidine: Enhanced hypotensive effect when Pentothal Sodium is given with moxonidine
Nitrates: Enhanced hypotensive effect when given with nitrates.Vasodilator antihypertensives: Enhanced hypotensive effect when general anaesthetics given with hydralazine, minoxidil or nitroprusside.
It should be noted that Pentothal Sodium will interact with beta-blockers and calcium antagonists, causing a fall in blood pressure.
The enhanced hypotensive effect is seen with ACE inhibitors when Pentothal Sodium is given.
Adrenergic neuron blockers: Enhanced hypotensive effect when Pentothal Sodium is given with adrenergic neurone blockers such as guanoxan, guanclofine and guanethidine.
The enhanced hypotensive effect may be seen when Pentothal Sodium is given with alpha-blockers.
Animal data suggest valerian and St John's Wort may prolong the effect of Pentothal Sodium.
Pretreatment with aspirin has been shown to potentiate Pentothal Sodium anaesthesia
Opioids potentiate the respiratory depressive effect. The effect is enhanced by alcohol, hypnotics, centrally acting muscle relaxants, anxiolytics, antipsychotics and antihistamines.

Interactions with food items

Pentothal's effects may persist longer than usual if you take St. John's wort. As a result, it should be avoided before any procedure that requires general anaesthesia or before any other usage of Pen...
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Storage and disposal of Pentothal 1 GM

Keep it in an airtight container at a controlled room temperature (15° to 30°C). Before opening: There are no particular storage requirements for the therapeutic product. Refrigerate for up to 24 hour...

Dosage of Pentothal 1 GM

Overdose

Because this medicine is provided in a hospital setting by a qualified healthcare provider, the chance of an overdose is relatively minimal. However, the doctor will begin immediate medical treatment ...

Missed a Dose

Because this medication is usually administered by a competent healthcare provider before and during a surgical procedure in a clinical/hospital setting, the chances of missing a dose are slim.

Content Details

WRITTEN BY

Dr. Shreya Aggarwal

Bachelor of Dental Surgery

REVIEWED BY

Dr. Vijay Y

MBBS, MD in Clinical Pharmacology

Frequently Asked Questions (FAQs)

Q: Is Pentothal Sodium toxic?

A: Pentothal Sodium is always administered intravenously. It can be fairly irritating to tissue and a vesicant; severe tissue necrosis and sloughing can occur if it is injected incorrectly into the tissue around a vein.

Q: How long does it take for Sodium Pentothal to work?

A: Pentothal (Thiopental Sodium for Injection, USP) is an ultra-short-acting central nervous system depressant that causes hypnosis and anaesthesia but not analgesia. Within 30 to 40 seconds after intravenous infusion, it induces hypnosis.

Q: How long does anaesthesia stay in your urine?

A: Anesthetic injections might last up to 24 hours in your system. If you've received sedation or regional or general anaesthesia, you shouldn't drive or return to work until the medicine has passed through your system.

References

Drugs.com. Thiopental Pregnancy and Breastfeeding Warnings. [Accessed 31 Apr 2022] (online) Available from

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Product Details

Brand

PENTOTHAL

Expires on or After

25/07/2025

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PENTOTHAL SODIUM 0.5GM DRY VIAL OF 1 POWDER FOR INJECTION

Last Updated on: 01 Aug 2023 | 12:12 PM (IST)

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