Luprorin Depot 3.75mg Dry Vial Of 1 Powder For Injection

• Luprorin Powder For Injection is used in men for the treatment of prostate cancer. It lowers testosterone levels, which helps slow the growth of cancer cells that depend on this hormone.
• In pre and perimenopausal women, it is used for hormone-responsive early and advanced breast cancer. It may also be prescribed to preserve ovarian function during chemotherapy.
• It is used in women to treat endometriosis and uterine fibroids, which may cause pelvic pain, heavy menstrual bleeding, and pressure symptoms. It can also reduce the thickness of the uterine lining before surgery.
• In children, it is indicated for central precocious puberty. It helps delay early sexual development by suppressing premature hormone release from the pituitary gland.

• If you are allergic to leuprorelin or any of the components of this medicine.
• If you are allergic to similar GnRH analogues such as goserelin or triptorelin.
• If you are pregnant or planning pregnancy.
• If you are breastfeeding.
• If you have abnormal vaginal bleeding that has not been discussed with your doctor.
• If the girl being treated for central precocious puberty is pregnant or breastfeeding.

• Hot flushes
• Sweating
• Headache
• Mood changes
• Depression
• Difficulty sleeping
• Bone pain
• Joint pain
• Muscle weakness
• Vaginal dryness
• Vaginal bleeding
• Decreased libido
• Erectile dysfunction
• Weight changes
• Injection site reactions
• Nausea
• Dizziness
• Fatigue

Other General Warnings

• You have diabetes, as blood glucose levels may change during treatment and require monitoring.
• You have heart problems or arrhythmia, as the risk of heart rhythm disturbances may increase.
• You have risk factors for osteoporosis, as bone thinning may occur during prolonged therapy.
• You develop a depressed mood or have a history of depression, as symptoms may worsen.
• You or your child have a history of seizures, as seizure episodes have been reported.
• You experience severe headache, visual disturbances, or ringing in the ears, as this may indicate increased intracranial pressure.
• You have fatty liver, as monitoring of liver function may be required.
• You have spinal cord compression or urinary obstruction due to prostate cancer, as symptoms may initially worsen.
• You are taking medicines that affect heart rhythm such as quinidine, amiodarone, or sotalol, as QT prolongation risk may increase.

• Luprorin Powder For Injection should be administered by a doctor or nurse. It is given as a subcutaneous injection in the arm, thigh, or abdomen. The injection site should be rotated regularly.
• It is usually given once every month. In specific conditions such as endometriosis or uterine fibroids, treatment duration may be limited as advised by the doctor. In children, dosing depends on body weight and is adjusted individually.

• Do not store above 25°C. Do not refrigerate or freeze. Store in the original container to protect from light. Use immediately after mixing with the sterile solvent.
• Do not use after the expiry date. Dispose of unused medicine as advised by your pharmacist.

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Interactions with other medicines

• Leuprorelin may interact with:
• Antiarrhythmic medicines such as quinidine, procainamide, amiodarone, and sotalol, which may increase risk of QT prolongation.
• Methadone, moxifloxacin, and antipsychotics, which may increase risk of heart rhythm disturbances.
• Antidiabetics, as blood glucose control may be affected.
• Monitoring may be required during combined use.