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Dothin 25mg Tablet

10 Tablet(s) in Strip
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Dothin 25 MG Description

Dotin 25 mg tablet is a prescription medicine. It is used to manage psychotic and neurotic depression and anxiety disorders. Treating depression not responding to previous therapies and chronic nerve

pain in some situations are a few of the other uses of the Dotin tablet. It is composed of Dosulepin or Dothiepin as its main component. It is an antidepressant medication. The mode of action of the Dotin tablet is by raising the levels of a specific chemical messenger in the brain called serotonin. It is responsible for lowering mood swings. Dotin tablets also help stabilise the chemical substances and decrease the symptoms of these conditions. It is not an addictive medication, but weight gain, confusion, increased heart rate, etc., are some of the side effects of the Dotin tablet. It is essential to follow your doctor's direction for using the Dotin tablet, as it has a relatively high toxicity in overdose. Do not stop using Dotin medicine suddenly, as it can cause withdrawal symptoms like sweating, tremors, cold, etc. Dotin tablets are not recommended for children and adolescents below 18. The usage should be monitored as it can cause suicidal thoughts.


Product Summary

Offer Price₹30.10
You Save₹4.90 (14% on MRP)
ContainsDosulepin / Dothiepin(25.0 Mg)
UsesDepression, Anxiety disorder, Nerve pain
Side effectsWeight gain or loss, Orthostatic hypotension, Excess sweating, Change in libido, Burning sensation in palms and soles, Slurred speech, Suicidal thoughts
Check more medicines with composition as Dosulepin / Dothiepin(25.0 Mg)

Uses of Dothin 25 MG

  • As per CDSCO, Dotin tablet is used for the following conditions:
  • It is used in the treatment of depression. It also includes subtypes of major depressive disorder such as psychotic depression (severe depressive disorder includes some form of psychosis such as hallu...
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  • It is indicated in the treatment of depression unresponsive to other antidepressants.
  • It is used in the management of anxiety disorder.
  • It is also sometimes used to reduce nerve pain, such as fibromyalgia, and prevent migraines.

Contraindications of Dothin 25 MG

  • It is contraindicated in the following cases:
  • If you have a known allergic reaction to any of its components
  • If you are already using other antidepressants or antipsychotics. It can cause hallucinations, seizures and different life-threatening side effects
  • If you have any serious heart condition, like a heart attack, irregular heart rhythm
  • If you have a rare blood-related illness known as porphyria
  • If you have previously been diagnosed with bipolar disorder or mania
  • If you have severe liver impairment
  • If you are currently expecting or planning for a pregnancy
  • If you are breastfeeding
  • If you have closed-angle glaucoma, a severe eye condition
  • If you notice any sudden mood changes and self-harming or suicidal thoughts
  • If you are younger than 18 years

Side effects of Dothin 25 MG

  • Side effects of Dotin tablet include the following:
  • Increased heart rate
  • Weight gain
  • Blurred vision
  • Sudden fall in blood pressure
  • Shaking of arms and feet
  • Low sex desire
  • Dry mouth

Precautions and Warnings of Dothin 25 MG



Can I take the Dotin 25 mg tablet during pregnancy?
No, the Dotin 25 mg tablets are unsafe during pregnancy. There are limited studies on this, and animal studies have shown a risk to the developing baby. Sometimes doctors may prescribe it during life-threatening conditions if they think the benefits outweigh the risks. Do not take it without consulting your doctor.

Breast Feeding

Can I take the Dotin 25 mg tablet while breastfeeding?
No, do not use Dotin Tablets during breastfeeding without consulting your doctor. Not enough information is available on the effects of this medicine in breastfeeding bodies. Some human data suggest that it can be safe if the infant is older than two months. It is better to monitor the baby for drowsiness, nausea, vomiting, etc.


Can I drive if I have taken the Dotin 25 mg tablet?
No, do not drive after taking the Dotin tablet. It can cause side effects like drowsiness, dizziness, and blurred vision that can affect your ability to drive.


Can I consume alcohol with the Dotin 25 mg tablet?
No, you cannot consume alcohol with a Dotin tablet. It can interfere with the function of the Dotin tablets and cause exaggerated side effects like drowsiness, confusion, tremors, dizziness, etc.

Other General Warnings

Talk to your doctor if
  • Your blood pressure suddenly drops; dotin tablets can lower blood pressure when you suddenly change your position.
  • You have prostate gland disorder. Dotin tablets can worsen the condition.
  • You are using other herbal medicines and supplements
  • You are an older adult; this medicine’s effects can last longer. The dose should be monitored.
  • You have any surgery or dental procedure planned.
  • You have any kidney or liver condition; dose adjustment might be needed.

Mode of Action of Dothin 25 MG

How Does It Work?

Dotin contains dosulepin as the main ingredient. It belongs to the tricyclic antidepressant class of medicines. It is believed that it works by stopping the reuptake of chemical messengers like norepi...
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Directions for Use of Dothin 25 MG

  • Take the Dotin tablet exactly as prescribed by the doctor.
  • Do not change the dose of Dotin tablet, even if you do not see its effects.
  • Do not try to break this tablet or chew it and the pill as a whole with a glass of water.
  • It is better to not take it with other medications without informing your doctor.
  • Do not use Dotin medicine if its packaging has been already opened.
  • Do not suddenly stop taking the Dotin tablet, as it can cause adverse effects from withdrawal.
  • Take Dotin medication with or without food.

Interactions of Dothin 25 MG

Interactions with other medicines

  • Do not use Dotin Tablet if you already use other antidepressants like MAO inhibitors such as linezolid, methylene blue, phenelzine, selegiline, etc. They can lead to severe side effects, such as tremo...
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  • Do not take other antidepressants with a similar composition like amitriptyline, imipramine, etc. They can exaggerate the side effects of Dotin medicine.
  • Do not use Dotin tablets with other medicines that cause sedation and drowsiness, like tranquillisers, opioid or narcotic pain relievers, muscle relaxants, etc., without consulting a doctor.
  • If you use antibiotics, antifungal, migraine medicines, Dotin tablets can decrease their effects.
  • Dotin tablets can have interactions and side effects with stomach ulcers, antimalarial medicines, heart medicines, and blood thinners.

Interactions with food items

  • Try to avoid drinking grapefruit juice and cranberry juice or eating those fruits while taking Dotin Tablets, as they can increase the levels of this medicine in your blood. It can lead to unwanted ad...
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Storage and disposal of Dothin 25 MG

Store Dotin tablets in dry conditions and at room temperature. Keep these medicines away from wet surfaces, direct sunlight and humid conditions. Keep Dotin Tablets away from children and pets. Dispo...
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Dosage of Dothin 25 MG


Dotin tablets have high toxicity levels and can easily lead to overdose. Overdose of the Dotin tablet can cause symptoms like low blood pressure, low temperature, dry mouth, increased reflexes, seizur...
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Missed a Dose

If you have missed a single dose of the Dotin Tablet, take it as soon as you recall. If you remember missing a dose of this medicine when it is almost the time to take the next Dotin tablet, skip the ...
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Content Details


Dr. Varsha Parihar

MBBS, MD (Community Medicine)

Frequently Asked Questions (FAQs)


Q: Is the Dotin 25 mg tablet a habit-forming medication?

A: No, Dotin tablets are not habit-forming medicines. But, it can cause withdrawal side effects when you stop using it suddenly. It should be slowly tapered. Consult your doctor first.

Q: Can I gain weight on the Dotin 25 mg tablet?

A: Dotin tablets can change your appetite, leading to weight loss or gain, especially initially. Its effects vary from person to person. Try to monitor your food and exercise regularly.

Q: When should I take the Dotin 25 mg tablet?

A: You should follow your doctor's advice precisely regarding the dose, duration, and time. You can take it at any time, preferably at night, as this medication causes drowsiness. Try to take it at the same time every day.
Product Details
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Last Updated on: 24 Mar 2022 | 09:40 PM (IST)

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