Dosulepin / Dothiepin

• Treatment of depression or depression associated with psychotic symptoms
• Treatment of anxiety disorder
• Treatment of neuropathic pain
• Treatment of chronic pain

When should one not use Dosulepin / Dothiepin

• If you have an allergic reaction to any components of Dosulepin / Dothiepin
• If you are already taking antidepressants, anti-anxiety or sedative medications
• If you are taking narcotic or opioid pain relievers
• If you have heart disease, like a heart attack, irregular heart rhythm
• If you are diagnosed with closed-angle glaucoma, a severe eye condition
• If you have any self-harming or suicidal thoughts and behaviour
• If you have severe liver disease
• If you are pregnant
• If you are a breastfeeding mother

Common side effects of this drug are:

• Drowsiness
• Headache
• Nausea
• Vomiting
• Dry mouth
• Diarrhoea or constipation
• Increased sweating

Other General Warnings

• You have any allergic reactions after taking Dosulepin / Dothiepin.
• You notice any sudden self-harming thoughts or suicidal ideation.
• You have trouble breathing or talking.
• You experience any severe side effects persistently.
• You have any planned surgery or dental procedure.
• You have a history of kidney or liver disease; dose adjustment might be needed.
• You are pregnant or plan to get pregnant.

How Does It Work?

Interactions with other medicines

• Concomitant use of Dosulepin / Dothiepin with other CNS depressants like Alprazolam and opioids like Codeine is strictly contraindicated, as it may cause respiratory depression, coma and death.
• Dosulepin / Dothiepin should not be used concomitantly or within two weeks of using Monoamine oxidase inhibitors (MAOIs) like isocarboxazid, linezolid, methylene blue, Selegiline, Rasagiline, etc. It is potentially life-threatening.
• Dosulepin / Dothiepin interaction with other antidepressants, antihistamines (allergy medicines), Pain killers, such as morphine, oxycodone, fentanyl, hydrocodone, tramadol, codeine, sleeping pills, etc., can increase drowsiness and fatigue.
• Dosulepin / Dothiepin Interaction with antibiotics like Clarithromycin, antifungals like ketoconazole, and migraine medicines like Sumatriptan can decrease their effects.
• Dosulepin / Dothiepin interaction with herbal products like St John's wort can lead to life-threatening side effects.

Interactions with food items

• Avoid consuming tyramine rich foods such as cheese, milk, meat, chocolate, chicken liver, grapefruit juice, etc., while taking Dosulepin / Dothiepin.

Overdose

Missed a Dose