Ticagrelor
Molecule Description
Platelet inhibitor (platelets help in blood clotting).
Uses of Ticagrelor
- Heart attack
- To reduce the risk of stroke in patients having a history of heart attack or chest pain
- In patients who have stents inserted (i.e. to prevent blocking of the stent with a blood clot)
Contraindications of Ticagrelor
When should one not use Ticagrelor
- You are allergic to Ticagrelor
- You have any active bleeding currently
- You have a history of intracranial bleeding or history of bleeding from ulcer in the stomach or intestine
- In patients in whom aspirin is contraindicated
Side effects of Ticagrelor
Common side effects of this drug are:
- Allergic reaction like fever, chills, rash, hives, breathing difficulty, swelling over your face, lips, throat
- Bleeding from an unusual site (mouth, nose, rectum, vagina, gums)
- Easy bruising, pinpoint rash on the skin
- Easy weakness and fatigue
- Red or pink urine
- Diarrhea
- Itching
- Fainting
- Blood in the stool (red or black ), cough or vomit (coffee coloured vomit)
- Shortness of breath
- Sudden numbness or weakness on one side of the body with problems in speech, balance and vision and excessive headache indicating of stroke (serious side effect)
- Yellowing of eyes or skin, weakness, fever and anorexia (suggestive of liver problems)
Precautions and Warnings of Ticagrelor
Pregnancy
Q:
Can I take Ticagrelor during pregnancy?
A:
It is not recommended during pregnancy.
Breast Feeding
Q:
Can I take Ticagrelor while breastfeeding?
A:
It is unknown if Ticagrelor passes into breast milk. Consult your doctor before breastfeeding if you are on this medication.
Driving
Q:
Can I drive if I have consumed Ticagrelor?
A:
Generally, Ticagrelor does not affect the ability to drive; if you feel confused or dizzy after taking this, do not drive.
Alcohol
Q:
Can I consume alcohol with Ticagrelor?
A:
Alcohol should be avoided as it increases the risk of bleeding from the intestine and stomach.
Other General Warnings
Talk to your doctor if
- Have any liver disease
- Have any lung problem or difficulty in breathing
- Had any recent bleeding or injury or surgery or dental procedure
- Have an upcoming surgery
- Have a high uric acid level
- A sudden stoppage of medicine can increase the risk of heart attack or stroke
Mode of Action of Ticagrelor
How Does It Work?
Ticagrelor prevents the formation of a blood clot by not allowing the platelets to stick together in the blood. This prevents clot formation and blockage of essential vessels in the heart or other parts of the body....
Interactions of Ticagrelor
Interactions with other medicines
- Non-Steroidal Anti-Inflammatory Drugs like Naproxen, Ibuprofen, Diclofenac
- Taking medicine that contains more of Aspirin. Since Aspirin is already advised along with Ticagrelor. Consuming combination medicine that contains Aspirin can cause its overdose and result in bleeding...
- Antibiotics like Clarithromycin
- Antiviral medicine (Anti HIV medicine like Ritonavir and Atazanavir)
- Antifungal medicine like Ketoconazole
- Anti-seizure medications
- Tuberculosis medicines like Rifampicin
- Do not take Ticagrelor if you are already taking blood thinner medicines like Warfarin
Interactions with food items
No information is available.
Dosage of Ticagrelor
Overdose
Excess Ticagrelor ingestion may cause excessive bleeding from and inside different parts of the body. Seek emergency medical help immediately if you overdose.
Missed a Dose
Take medicine as soon as you remember. If the missed dose falls at the time of your next scheduled dose, then skip it. Do not take an extra dose to compensate for the missed dose.
Content Details
WRITTEN BY
Dr. Mansi Savla
B. Pharm, PharmD
REVIEWED BY
Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: When and how to consume the medicine?
- You must take medicine precisely the way the physician prescribes it. Follow the instructions mentioned on the prescription label
- Do not alter the dose unless recommended by your doctor. Please do not take it longer than advised
- Do not take more aspirin than prescribed by your physician as this may render Ticagrelor less effective
- The medicine can be taken with or without a meal but preferably at the same time daily
- Do not discontinue taking this medicine without informing your doctor, even if you have signs of bleeding
- A sudden stoppage of medicine can increase the risk of heart attack or stroke
Q: What else should I avoid while taking Ticagrelor?
A: Avoid activities that can result in injury and bleeding, e.g. rigorous exercise and take extra care while brushing your teeth, shaving, etc.
References
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