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Molecule Description

Minocycline is a broad-spectrum antibiotic from the group Tetracycline. It used for treatment of bacterial infections.

Uses of Minocycline

  • Urinary tract infections
  • Respiratory infections
  • Skin infections including acne
  • Gonorrhea (Gonococcal Infection)
  • Syphilis
  • Infective Endocarditis
  • Chlamydial infection

Contraindications of Minocycline

When should one not use Minocycline

  • If you are allergic to this medicine
  • If you have a history of kidney failure or if you are on dialysis treatment
  • If you suffer from myasthenia gravis (a disease that can cause muscle weakness)

Side effects of Minocycline

Common side effects of this drug are:

  • Nausea, diarrhea
  • Head pain
  • Loss of appetite
  • Joint pain
  • Drowsiness and
  • Dizziness
  • Discoloration of teeth
  • Itching, hives, rash and yellowing of the skin or eyes
  • Kidney complaints – less urine, painful urination and swelling of feet
  • Liver complaints – nausea, vomiting, stomach pain and jaundice
  • Brain symptoms – severe head pain, dizziness and vision
  • problems

Precautions and Warnings of Minocycline


Can I take Minocycline during pregnancy?
Do not take Minocycline if you are pregnant or planning a pregnancy as it can affect the development of your unborn baby.

Breast Feeding

Can I take Minocycline while breastfeeding?
Do not breastfeed if you are taking Minocycline as it can pass into breast milk.


Can I drive if I have consumed Minocycline?
Taking this medicine may lead to cause dizziness, headache. Do not drive until you feel well.


Can I consume alcohol with Minocycline?
Avoid alcohol and tobacco while on Minocycline as it may lead to cause dizziness.

Other General Warnings

Talk to your doctor if
  • You have any liver or kidney problems, muscle weakness
  • You experience during treatment difficulty in breathing, hair loss, joint pain, rash on face

Mode of Action of Minocycline

How Does It Work?

Minocycline is used to treat different bacterial infections affecting the urinary tract, respiratory system, skin infections, etc.

Interactions of Minocycline

Interactions with other medicines

  • Isotretinoin
  • Penicillin antibiotic - Amoxicillin, Ampicillin, Penicillin, and others
  • Blood thinner - Warfarin, Coumadin, etc.
  • Ergot medicine - Dihydroergotamine, and Ergotamine
  • One should not take iron supplements, multivitamins, antacids, or laxatives two hours before or after taking Minocycline. They make this medicine less effective

Interactions with food items

No specific interactions with food have been reported yet. Drink plenty of liquids to prevent dehydration when on this medicine.

Dietary Restrictions of Minocycline

No information is available on dietary restrictions while you are taking this medicine, consult your doctor or pharmacist for further information.

Dosage of Minocycline


Overdose symptoms may include dizziness, nausea or vomiting. Seek emergency medical care immediately.

Missed a Dose

Take your missed dose as early as you possible. Skip the missed dose & do not take extra medicine to compensate for the missed dose.

Content Details


Dr. Rukman Mecca

MBBS, MD (Community Medicine)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking Minocycline?

  • Inform the doctor about your detailed medical & surgical history
  • Inform your physician if you have any of the following conditions-
  • Liver disease
  • Kidney disease
  • Asthma
  • If you are pregnant, lactating or planning a pregnancy
  • Inform the doctor if you are taking hormonal birth control pills
  • Minocycline can make them less productive; so the doctor would need to prescribe you a non-hormonal birth control measure
  • Inform the doctor about the list of medicines you are taking
  • Certain medicines do not act well when taken along with Minocycline

Q: When and how to consume the medicine?

  • Minocycline should be taken in the exact dose as advised by the physician
  • Take this medicine with a glass of water. It can be taken with or without food

Q: Can I stop this medicine when I feel better?

A: Always complete the full course of treatment. You may start feeling better with the first few doses of the medicine but complete the course to kill all the bacteria or it will lead to antibiotic resistance.

Q: How does the medicine acts on the bacteria?

A: Minocycline passes either directly through the lipid bilayer or passively diffuses through porin channels in the bacterial membrane. It binds to the 30S ribosomal subunit present inside the bacterial cell, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis, thereby prevents the multiplication of bacteria and bacterial cell death.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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