Chloroquine

Molecule Description

Chloroquine belongs to a group of medicines called anti-malarials. It can be ta

ken in certain parts of the world to help prevent malaria.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Chloroquine

It is used in the treatment of malaria (caused by a parasite – common symptoms include chills and high fever)
Infection and pus formation in the liver due to parasitic infection (Amoebic Hepatitis and Liver Abscess)

Contraindications of Chloroquine

When should one not use Chloroquine

Allergy to Chloroquine or any ingredients of the medicine
Amiodarone, a medicine used to treat abnormal heart rhythms should not be used along with Chloroquine

Side effects of Chloroquine

Common side effects of this drug are:

Skin rashes, swelling of lips, face and tongue
Headache, feeling dizzy, unintentional muscle movements
Hearing loss, vision problems, increased sensitivity to light
Hair loss and changes in hair color
Abnormal heart rhythms, low blood pressure
Mood changes, depression, confusion, sleeplessness

Precautions and Warnings of Chloroquine

Pregnancy

Can I take Chloroquine during pregnancy?

Malaria can cause a lot of problems in pregnant women and Chloroquine is known to have the potential to harm the unborn baby. Hence, avoid it in pregnancy.

Breast Feeding

Can I take Chloroquine while breastfeeding?

Tiny amount of Chloroquine secretes in breast milk; when given once weekly or for 2-3 days like in malaria, the quantity of medicine is not sufficient to harm the infant. In case of long-term treatment for conditions like Rheumatoid Arthritis, you should avoid Chloroquine in breastfeeding for the above reason.

Driving

Can I drive if I have consumed Chloroquine?

You may have vision problems, especially when you start treatment with Chloroquine, and you are advised not to drive in the presence of any such symptoms. You must be cautious if you are on long-term medication, even in the absence of symptoms.

Alcohol

Can I consume alcohol with Chloroquine?

You should avoid alcohol as it may worsen certain side effects of Chloroquine such as dizziness, heart problems and depression.

Other General Warnings

Talk to your doctor if

Seizures (fits)
A genetic disorder causing purplish skin rashes due to defect in blood formation (porphyria)
Scaly rashes of the skin (psoriasis)
A type of muscle weakness (myasthenia gravis)
A genetic disorder causing increased breakdown of red blood cells (G6PD – Glucose 6 Phosphate Dehydrogenase deficiency)
Rabies vaccine or thyroid hormone reduces the effectiveness of Chloroquine

Mode of Action of Chloroquine

How Does It Work?

Chloroquine acts by killing sensitive malaria parasites at different stages of their development in our red blood cells. This medicine gets stored in the liver and hence is effective against liver par...

Interactions of Chloroquine

Interactions with other medicines

Amiodarone – to treat irregular heartbeats
Use with caution
Praziquantel (used to treat worm infections – tapeworm, etc.)
Digoxin (irregular heartbeats)
Anti-seizure medications (Phenytoin, Carbamazepine)
Cyclosporin (suppresses immune system)
Kaolin (treats diarrhea)
Medicines used to reduce stomach acid (Cimetidine, Omeprazole or antacids like aluminum, magnesium, etc.)
Ciprofloxacin (antibiotic)
Medicines for depression, thyroid or heart disease

Interactions with food items

Take Chloroquine tablets with food or immediately after a meal with a glass of water.

Dosage of Chloroquine

Overdose

Accidental overdose may not be life-threatening. But if you feel any discomfort or experience symptoms such as abnormal heartbeats, feeling dizzy, or any allergic reactions, consult your doctor.

Missed a Dose

Take the missed dose as you remember. Skip the missed dose; do not take extra medicine or double dose to compensate for the missed dose. Ideally, you should have a 12-hour gap between two doses.

Content Details

WRITTEN BY

Dr. Arpit Verma

MBBS, MD CCEBDM Diabetology

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: How should I take Chloroquine?

A: A patient can take Chloroquine in parasitic infections like malaria and amoebic liver disorders and certain conditions involving the immune system. There are four different types of malaria, though only two are more common; the dosage and duration may change for each type. Hence Chloroquine has to be taken under medical supervision to avoid irregular usage. The dosage of this medicine in immune disorders such as Systemic Lupus Erythematosus and Rheumatoid Arthritis also differs based on the severity of the disease. Improper administration may cause unwanted effects and hence self-medication with Chloroquine is not advised.

Q: How does Chloroquine act against blood parasites and the immune system?

A: Chloroquine can penetrate the parasites present in the blood (malaria) and the liver (Amoebiasis). After entering the parasite, it stops the formation of substances that may cause harm to us and thus control the infection. In diseases such as Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA) due to improperly regulated immune systems, Chloroquine disrupts the signaling between immune cells. It thus reduces or suppresses the unwanted immune system activity resulting in relief of symptoms. Chloroquine acts in different diseases with different mechanisms.

References

Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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परिचय: “बिना मशरूम के खाना बिना बारिश के दिन जैसा होता है”। मशरूम या अगरिकस बिस्पोरस न तो सब्ज़ी है और न ही फल, बल्कि यह खाई जाने वाली एक फंगस है। बाजार में इसकी अलग-अलग किस्में (ताजा व सूखा) उपलब्ध हैं; जिसमे ओएस्टर , पोर्सिनी और बटन सबसे आम किस्में हैं। आमतौर पर, मशरूम

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परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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