Coxito S 10mg Tablets

• As per CDSCO, Coxito S tablet is used for:
• Treatment of symptoms of major depressive disorder (persistent feeling of sadness, loneliness, and loss of interest in life)
• Treatment of panic disorders (a type of anxiety disorder), with or without agoraphobia (fear of open and crowded places)

• If you have any allergic reaction to any of the components of this medicine.
• If you have a known history of alcohol or addiction or a mental health disorder.
• If you have a seizure disorder and are currently on antiepileptic (anti-seizure) medication.
• If you are pregnant or planning a pregnancy.
• If you are nursing; this medicine may cause side effects on the baby.
• If you use other anti-anxiety medicines or sedatives, they can interfere with Coxito S and cause adverse reactions.
• If you are diagnosed with acute-angle glaucoma (an eye condition that causes high fluid pressure inside the eye).
• If you have a severe liver disease.

• Confusion
• Sleepiness
• Fatigue
• Nausea
• Diarrhoea
• Constipation
• Changes in sexual drive

Other General Warnings

• You notice sudden mood changes or have suicidal thoughts after taking Coxito S tablets.
• You experience changes in your sexual desires after taking Coxito S tablets.
• You use any Ayurvedic and herbal medicines (St John’s Wort) or take vitamins and supplements; these can interact with Coxito S tablets and cause serious side effects.
• You use pain relievers or other medications that cause sedation or tranquillisation.
• You are an older adult over 65. The effects of this medicine may exaggerate in older persons and must be used with caution.
• You have been diagnosed with a seizure disorder and are on antiepileptic medicines.
• You are planning to have surgery or a dental procedure.
• You recently had a heart attack or stroke.
• You have high blood pressure.
• You have been diagnosed with respiratory or lung disease.
• You have kidney disorders. While Coxito S can be safe, consult a doctor as one of the side effects of this medicine is an increase in end-stage kidney failure.
• You have or had a liver condition; this medicine may need some dose adjustment.
• You are a child or adolescent under 18.

• Take Coxito S precisely in the dose and duration prescribed by the doctor.
• Do not take more than the recommended dose of Coxito S even when you cannot notice its effects.
• Take the tablet as a whole with a glass of water. Do not break or chew it.
• Do not take the tablets with other medications without informing your doctor.
• Do not use the tablets if their packaging is damaged.
• Do not stop using Coxito S medicine abruptly.
• Take the tablet with or without food. In case of any stomach issues, take it after a meal.

Overdose

Missed a Dose

How Does It Work?

Interactions with other medicines

• Certain anti-anxiety and mood disorder medicines like monoamine oxidase inhibitors (MAOIs) (linezolid, moclobemide, etc.) combined with Coxito S can cause severe reactions. They inhibit serotonin metabolism and can result in serotonin levels high enough to produce heart and neurotoxic serotonin syndrome.
• Combining other antidepressant medicines like fluoxetine, paroxetine etc., with Coxito S can raise serotonin levels and lead to serotonin toxicity with life-threatening side effects.
• If you have bleeding issues or take blood thinners, use Coxito S with caution, as this medicine may increase the risk of bleeding.
• Do not take other medicines that cause drowsiness, such as allergy, cold and cough medicine, opiates, or narcotic pain relievers with Coxito S. These medicines can increase the side effects of Coxito S and cause extreme drowsiness.
• Antiepileptic medicines for seizure disorders can increase the side effects of Coxito S.

Interactions with food items

• Avoid grapefruit and its juice, as this fruit can worsen the side effects of Coxito S.
• Avoid coffee and caffeine products and chocolates and desserts; these foods can increase serotonin levels and cause serotonin toxicity. High levels of serotonin can cause severe side effects in the body.