Cizaspa-X Tablet
10 Tablet(s) in StripWe do not sell this product
Made by
LUPIN
Dosage
TABLET
Expiry
Product Summary
| Salt Content | Chlordiazepoxide(5.0 Mg)+Mebeverine(135.0 Mg) |
| Uses | Irritable Bowel Syndrome |
| Therapy | Drugs for irritable bowel syndrome |
| Side effects | Nausea, vomiting, skin reactions, rashes, hypersensitivity, drowsiness, sedation, poor coordination, memory impairment, weight gain/loss, increased/decreased appetite, facial oedema |
Assurance
available
Regulated
Medical Description
Cizaspa-X Tablet is a prescription medication. Cizaspa-X Tablet aids in the treatment of a condition known as Irritable Bowel Syndrome(IBS). It is a combination medication consisting of two active components – mebeverine and chlordiazepoxide.
Irritable bowel syndrome is long-lasting and relapsing in nature. It is characterised by abdominal pain with some variation of disorderly defecation (diarrhoea, constipation, or alternating between diarrhoea and constipation). Common symptoms of IBS include cramps, Stomach ache, loose stools, constipation, bloating.
Use this medication as directed by your physician. Cizaspa-X Tablet should be taken without food. It is important to follow lifestyle modifications as directed by your doctor in addition to this medication for optimal efficacy. Consumption of alcohol while on Cizaspa-X Tablet is strictly contraindicated. Give your doctor details about any other medicine you are taking at the time of prescription. This medicine is considered unsafe during pregnancy and breastfeeding. In case you are planning a pregnancy or are breastfeeding, inform your doctor about the same.
Uses
- Treatment of Irritable Bowel Syndrome (IBS)
Contraindications
- If you have hypersensitivity to mebeverine/ chlordiazepoxide
- If you have been diagnosed with advanced liver and kidney disease
- If you have a history of cardiac illness
- If you have angle-closure glaucoma.
- If you are pregnant.
- If you have rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption.
- It is recommended to discontinue this medication before elective surgery to decrease the risk of interaction with anaesthetic agents.
Side effects
- Indigestion
- Heartburn
- Dizziness
- Insomnia
- Anorexia
- Headache
- Decrease in pulse rate
- Constipation
- General malaise
- Drowsiness
- Memory impairment
- Poor coordination
- Sedation
- Weight gain/ loss
- Increased/decreased appetite
- Decreased libido
- Increased salivation
- Confusion
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You experience persistent or worsening side effects.
- You conceive or are planning a pregnancy during the course of medication.
- You are breastfeeding.
- You are taking any herbal medicines or supplements.
Directions for Use
- Cizaspa-X Tablet should be taken as prescribed by the treating physician.
- Swallow this medication as a whole. Do not chew, break, or crush this tablet.
- It is recommended to finish the full course of this medication as prescribed by your treating doctor. Abrupt stoppage of the medicine can cause withdrawal side effects. Consult your doctor before stopping this medication.
- Driving/use of heavy machinery is not advised while using this medication.
- Inform your doctor regarding other medications you may be taking in order to review and prevent any medicine interaction associated effects.
Storage and disposal
Store in a cool and dry place away from direct light and moisture. Do not use the medicine after the expiration. Keep the tablets away from the reach of children and pets. Do not flush the medication down the toilet. Dispose of it with biomedical waste only.
Dosage
Overdose
Symptoms of overdose of Cizaspa-X Tablet are those of neurological and cardiovascular nature. These include confusion, diminished reflexes, somnolence(excessive sleepiness), coma, etc.
In case of a suspected overdose, the patient's vital functions should be monitored closely. Treatment is symptomatic and supportive. Rush patient to a tertiary care hospital for monitoring and management.
Missed a Dose
In case one or more doses of Cizaspa-X Tablet are missed, continue with the next regular dose as prescribed. Do not take the missed doses in addition to the regular dose. Do not increase the dose without the direction of your treating physician.
Mode of Action
How Does It Work?
Mebeverine and chlordiazepoxide are the active ingredients of Cizaspa-X Tablet.
Mebeverine is a medication that reduces the motility of the gut by inhibiting a process called peristalsis. Peristalsis is the physiological process by which the food is transported through the various regions of the gut as digestion takes place. For this to occur, the smooth muscles of the gut contract and relax rhythmically. In IBS, this produces crampy, spasmodic pain. Mebeverine is an antispasmodic agent that causes relaxation of the smooth muscles, decreasing this forward propulsive peristalsis and reducing abdominal pain. It belongs to a group of agents called anticholinergics.
Chlordiazepoxide is a benzodiazepine or tranquilliser that has calming, sedative effects on the brain. Studies have shown a direct correlation between increased stress levels, anxiety, & depression and IBS. Increased stress levels cause increased gut motility. Chlordiazepoxide acts as an antianxiety, stress-relieving medication. It does so by acting on certain brain pathways to increase the levels of a chemical called GABA (gamma-aminobutyric acid). GABA is a neurotransmitter, which means it is a chemical that relays information along brain pathways. GABA’s effects are predominantly inhibitory, hence increasing its levels produces the desirable effects in decreasing anxiety.
Interactions
Interactions with other medicines
- This medication should not be taken in conjecture with any other CNS depressant (like alcohol) or opioid medication, as it may cause respiratory depression, coma and death.
- This medication should not be mixed with other benzodiazepines or tranquillisers.
Interactions with food items
- This medication is to be taken 20-30 minutes before taking food for optimal functioning.
- In addition, it is important to regulate your diet for the management of IBS. Fibre-rich food, plenty of fluids, avoiding specific items like red meat, certain vegetables, etc., is highly beneficial in managing IBS. Your treating physician will be able to provide you with more information on dietary modifications to be made to decrease symptoms of IBS effectively.
Frequently Asked Questions (FAQs)
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Manufacturer Details
Brand:CIZASPA
Manufacturer Name:LUPIN
Address:<p>1. Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India</p>
Country of Origin:India
Vendor Details
Fulfillment Information: Cizaspa X Strip Of 10 Tablets will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.
References:
- Mebeverine: Uses, Interactions, Mechanism of Action. Drug Bank Online Drugbank.com. [cited 2022 Feb 10]. Available from:
- Darvish-Damavandi M, Nikfar S, Abdollahi M. A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome. World J Gastroenterol [Internet]. 2010;16(5):547–53. Available from:
- Annaházi A, Róka R, Rosztóczy A, Wittmann T. Role of antispasmodics in the treatment of irritable bowel syndrome. World J Gastroenterol [Internet]. 2014;20(20):6031–43. Available from:
- Librium (chlordiazepoxide) dosing, indications, interactions, adverse effects, and more [Internet]. http://reference.medscape.com. 2020 [cited 2022 Feb 10]. Available from:
- Irritable bowel syndrome: A review of treatment options [Internet]. Medscape. 2018 [cited 2022 Feb 10]. Available from:
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Disclaimer
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