Tamoxifen

Q: What should I discuss with my health care expert before taking Tamoxifen?

You cannot use this Tamoxifen if you are allergic to it , Inform your doctor if you currently are or had suffered from clots in your lungs or veins , Inform your doctor if you are on blood thinners like Warfarin , Tell your doctor if you are on chemotherapy or radiation , You must inform your doctor if you are suffering from any heart disease or have a history of stroke, cataract or blood clot , If you have high cholesterol or triglycerides

Molecule Description

Tamoxifen is used to treat estrogen hormone-dependent breast cancers, stimulate

ovulation and prevent breast cancer in high risk patients. It belongs to a class of medicines called ‘Non-Steroidal Anti-Estrogens.’

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Tamoxifen

Some types of breast cancer in women and men
Stimulate release of eggs from the ovary (ovulation) in females with who are problems (anovulation)
Prevent development of breast cancer in high-risk patients (e.g. family history of breast cancer)

Contraindications of Tamoxifen

When should one not use Tamoxifen

If you are allergic to Tamoxifen
If you are taking Anastrozole
If you or someone in your family has had blood clots due to unknown causes (idiopathic)
If you have a history of blood clot formation in the legs or lungs (deep vein thrombosis or pulmonary embolism)
If you are taking medicines used to prevent blood clots such as Warfarin
If you are not sure, discuss to your doctor or pharmacist before taking Tamoxifen tablets

Side effects of Tamoxifen

Common side effects of this drug are:

Fluid retention
Skin rash
Hot flushes (feeling of heat and sweats)
Vaginal bleeding or discharge
Tiredness
Uterine fibroids
Anaemia (a blood problem which means you have too few red blood cells)
Changes in vision due to cataracts or changes to the retina of your eye
Increased amounts of fats in your blood (shown by blood tests)
Allergic reactions
Cataracts and eye problems
Increased risk of blood clots (including clots in small vessels)
Changes in the womb (including changes to its lining and benign growths)
Headache
Feeling light-headed
Liver problems
Loss of hair
Muscle pain
Sensory changes (including taste disturbances and numbness or tingling in the skin)
Severe blood problems (reduced blood cell counts) - this can get you to bruise more easily, get serious infections or feel very tired or breathless (rare)
Changes to the cornea of your eye (rare)
Problems with the nerve that connects your retina to your brain (swelling of the optic nerve)
Severe life-threatening liver diseases – include liver infections, liver cirrhosis, liver cell damage, reduced bile formation and complete liver failure (rare)
Severe life-threatening allergic reactions (angioedema, vasculitis, Stevens-Johnsons syndrome, etc.)
Suppression of menstruation (rare)
Vaginal growths (polyps)
Infections and increased thickness of lining of the uterus (endometrium)
Other uncommon cancers (rare)

Precautions and Warnings of Tamoxifen

Pregnancy

Can I take Tamoxifen during pregnancy?

Do not start the medication of Tamoxifen if you are pregnant. It can cause birth defects, harm the unborn baby (fetus) and abortions.

Breast Feeding

Can I take Tamoxifen while breastfeeding?

Since Tamoxifen can suppress the production of breast milk after giving birth (postpartum lactation), it is not known if it is secreted in breast milk, it should be avoided in nursing mothers.

Driving

Can I drive if I have consumed Tamoxifen?

Tiredness has been reported in some patients. Hence caution is recommended and it is advised to avoid driving if you have such symptoms.

Alcohol

Can I consume alcohol with Tamoxifen?

It is recommended not to use alcohol with Tamoxifen as both Tamoxifen and alcohol increase liver enzymes. Also, alcohol interacts with Tamoxifen, decreasing its efficacy. It also increases the risk of breast cancer and delays recovery.

Other General Warnings

Talk to your doctor if

You have delayed breast reconstruction operation (repeated procedure after the primary breast operation)
Tamoxifen may increase the risk of the formation of blood clots
Menstruation may be suppressed in some patients
Changes in the lining (endometrium) of the uterus (increased thickness and unwanted growths)
Cancerous growths (secondary tumors) at sites other than breast and lining of the uterus (endometrium)

Mode of Action of Tamoxifen

How Does It Work?

Estrogen dependent breast cancers are the most common type of breast cancers
Tamoxifen blocks the uncontrolled breast growth due to signals from estrogen hormone and thus stops progression of breast cancer
In females with ovulation problems (releasing eggs from ovaries between 10-15th day of a regular menstrual cycle)
Tamoxifen acts on structures in the brain, regulates estrogen levels and causes release of the eggs (improving female fertility)

Interactions of Tamoxifen

Interactions with other medicines

Carbamazepine (used to treat seizures)
Erythromycin (anti-bacterial)
Amiodarone (used to treat irregular heartbeats)
Warfarin (blood-thinning agent)
Rifampicin (used to treat TB)
Ritonavir (HIV medicine)
Dexamethasone (steroid used to treat allergies, skin and joint diseases)
Certain antidepressants (Paroxetine, Fluoxetine, Bupropion)
Quinidine (used to treat irregular heartbeats)

Dietary Restrictions of Tamoxifen

Multivitamins, herbal supplements and soya products may trigger breast tumor growth and interfere with the action of Tamoxifen.

Dosage of Tamoxifen

Overdose

Accidental overdose of Tamoxifen may not be life-threatening as there will be no immediate effects. But take your doctor’s advice in case of overdose. Medical attention may be necessary in case of ext...

Missed a Dose

Take the missed dose as early as you remember. If the time for next dose is near, skip the missed dose & do not take two doses together to compensate for the missed dose.

Content Details

WRITTEN BY

Dr. Mansi Savla

B. Pharm, PharmD

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: What should I discuss with my health care expert before taking Tamoxifen?

You cannot use this Tamoxifen if you are allergic to it
Inform your doctor if you currently are or had suffered from clots in your lungs or veins
Inform your doctor if you are on blood thinners like Warfarin
Tell your doctor if you are on chemotherapy or radiation
You must inform your doctor if you are suffering from any heart disease or have a history of stroke, cataract or blood clot
If you have high cholesterol or triglycerides

Q: What else should I know if I am prescribed Tamoxifen?

A: Use effective contraception methods (to prevent pregnancy) like condoms or loops. Pill based contraception is not recommended while using Tamoxifen. It is important to use contraception until two months after stopping the medication of Tamoxifen.

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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एक स्वस्थ जीवन जीने और वज़न कम करने के लिए हम अलग-अलग तरीकों और स्वास्थ्यवर्धक काढ़ों जैसी चीज़ें आज़माते रहते हैं। अनगिनत स्वास्थ्य लाभों का वादा करने के अलावा, ये शरीर को डिटॉक्स करने और वज़न घटाने में मदद करने का भी दावा करते हैं। लेकिन एक पेय (ड्रिंक) है जो ऐसा करने में कामयाब

मशरूम (Mushroom in Hindi) के उपयोग, फ़ायदे, और न्यूट्रिशनल वैल्यू

परिचय: “बिना मशरूम के खाना बिना बारिश के दिन जैसा होता है”। मशरूम या अगरिकस बिस्पोरस न तो सब्ज़ी है और न ही फल, बल्कि यह खाई जाने वाली एक फंगस है। बाजार में इसकी अलग-अलग किस्में (ताजा व सूखा) उपलब्ध हैं; जिसमे ओएस्टर , पोर्सिनी और बटन सबसे आम किस्में हैं। आमतौर पर, मशरूम

आंवला (Gooseberry in Hindi) के उपयोग, फ़ायदे और न्यूट्रिशनल वैल्यू

परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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