Diclofenac+Metaxalone
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Molecule Summary
| Uses | Muscle spasm, muscle pain |
| Therapy | Muscle Relaxant, Analgesic |
| Side Effects | Headache, dizziness, nausea, vomiting, stomach upset |
Medicines
available
19k pincodes
Molecule Description
Diclofenac+Metaxalone is a combination medication used to relieve muscle pain and discomfort caused by injuries or sprains. It contains diclofenac, an NSAID that reduces inflammation and pain, and metaxalone, a muscle relaxant. This combination helps to alleviate pain and discomfort by reducing inflammation and relaxing the affected muscles.
Diclofenac+Metaxalone may cause side effects such as headache, nausea, vomiting, and dizziness. While these side effects are usually temporary, consult your doctor immediately if they persist or worsen.
Diclofenac+Metaxalone should be taken exactly as prescribed by your doctor, preferably with food to minimise stomach upset. Before starting Diclofenac+Metaxalone, inform your doctor about all existing medical conditions, including pregnancy, breastfeeding, or any plans to become pregnant.
Uses
Diclofenac+Metaxalone is used for the treatment of pain due to muscle spasm. It relieves pain, swelling and discomfort of muscle and improves muscle movement and activity.
Contraindications
When should one not use Diclofenac+Metaxalone
- If you are allergic to diclofenac and metaxalone or any other ingredients of Diclofenac+Metaxalone.
- If you are suffering from acidity problems, have a history of recurrent peptic ulcer or bleeding disorder
- If you have a history of stomach or intestine bleeding or perforation, relating to the previous use of pain killer (NSAIDs) medicines or if you have any liver or kidney problems.
- If you have heart problems like congestive heart failure (decreased pumping of the heart), ischemic heart disease (heart attack due to blood supply disturbance), peripheral arterial disease (a condition in which there is reduced blood flow to limbs), cerebrovascular disease (a problem in blood flow in the brain), stroke, heart attack or any other heart issues.
- If you have a history of attacks of asthma, angioedema (swelling of face, skin and tongue breathing problem), urticaria (skin redness and itching) or acute rhinitis (runny nose, sneezing, etc.)
- If you have a history of decreased blood count due to any medicines in the past
- If you have anaemia or have problems with your blood circulation
- If you are pregnant or are breast-feeding
- If you are taking aspirin or other NSAID painkillers
Side effects
Common side effects of this drug are:
- Headache
- Dizziness
- Nausea
- Vomiting
- Diarrhoea
- Stomach pain
- Nervousness
- Irritability
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You are experiencing high blood pressure, increased heartbeats, increased body temperature, sweating, agitation and irritation
- You are above 65 years, as it should be used cautiously in elderly patients
- You have blood clotting, liver, kidney and heart problems
- You have asthma, diabetes, high blood pressure or cholesterol
- You are pregnant or an active smoker
- You had or may have a surgery
- You are having diseases like Systemic Lupus Erythematosus or mixed connective tissue disease
- You are taking water pills or painkillers
- You are going for a lab test, as this medicine may interfere with the lab tests, inform the concerned person.
- This medicine should not be used in children below 12 years of age.
- Diclofenac+Metaxalone may impair female fertility and is not recommended in women who want to conceive or are of childbearing age.
Mode of Action
How Does It Work?
Diclofenac+Metaxalone is a medication that contains a combination of two active ingredients, diclofenac and Metaxalone, to alleviate muscle pain. The medicine works by relaxing the muscles through its action on the central nervous system. It also helps to lower the levels of chemical substances that cause pain and inflammation in the body.
Interactions
Interactions with other medicines
- Diclofenac+Metaxalone can interact with several other medications, potentially increasing the risk of side effects or reducing their effectiveness.
- Serious Interactions: Combining Diclofenac+Metaxalone with certain medications like fentanyl, methadone, and triptans can significantly increase blood pressure, heart rate, and body temperature, potentially leading to a medical emergency.
- Blood Pressure Medications: Using Diclofenac+Metaxalone with certain blood pressure medications, such as atenolol, propranolol, captopril, and lisinopril, may decrease their blood pressure-lowering effects.
- Immunosuppressants: Combining Diclofenac+Metaxalone with medications like cyclosporine and tacrolimus can increase the risk of muscle weakness and irregular heartbeats.
- Blood Thinners: Combining Diclofenac+Metaxalone with blood thinners like warfarin and heparin can increase the risk of bleeding.
- Other Medications: Diclofenac+Metaxalone may also interact with other medications, including psychiatric medications, painkillers, cholesterol-lowering medications, antibiotics, and medications used for heart conditions, seizures, fungal infections, and HIV.
Interactions with food items
Diclofenac+Metaxalone can be taken with or without food. However, it is best to take it with food or just after a meal to avoid stomach upset.
Dosage
Overdose
- If you have taken more Diclofenac+Metaxalone you may get symptoms like headache, nausea, vomiting, pain below the ribs and above the stomach, and occasionally fits.
- If you experience any of the symptoms or think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
Missed a Dose
If you missed any dose of Diclofenac+Metaxalone, take it as soon as you remember. If it's time for your next dose, skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate for the missed one.
Frequently Asked Questions (FAQs)
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References:
- Metaxalone Tablets, USP [Internet]. Accessdata.fda.gov. 2022 [cited 3 June 2026]
- Diclofenac Potassium 50 mg Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [cited 3 June 2026]
- Diclofenac Potassium 50 mg Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2022 [cited 3 June 2026]
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 3033, Diclofenac. Retrieved December 30, 2024
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 15459, Metaxalone. Retrieved December 30, 2024
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