Omnacortil 10 Tablet
10 Tablet(s) in StripProduct Summary
Omnacortil 10 mg Tablet, from Macleods Pharmaceuticals, contains prednisolone 10 mg, a corticosteroid used for severe allergies and inflammatory or autoimmune disorders. It helps prevent or treat organ rejection after transplantation and forms part of combination treatment for certain blood cancers. Prednisolone suppresses immune responses involved in allergy and inflammation.
Medically Reviewed by Dr. Ritu Budania
Last updated on: 13 October 2026 | 11:26 AM (IST)
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MACLEODS PHARMACEUTICALS
Dose Form
TABLET
Expiry
General Information
| Therapy | Steroid |
| Composition | Prednisolone(10.0 Mg) Prednisolone 10.0 Mg |
Prednisolone 10.0 Mg

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*Offer applicable on orders above ₹1000About Omnacortil 10
Omnacortil 10 Tablet is a prescription corticosteroid medicine used to manage a wide range of health conditions that involve inflammation, immune system overactivity, or allergic reactions. It is commonly prescribed for allergic conditions such as asthma, severe allergic rhinitis, and eczema, as well as for autoimmune and inflammatory disorders like rheumatoid arthritis, systemic lupus erythematosus, and certain skin conditions. It may also be used in kidney diseases such as nephrotic syndrome, in lung disorders like chronic obstructive pulmonary disease (COPD), and in various rheumatic and connective tissue diseases. In some cases, it is given alongside appropriate antimicrobial treatment for specific infections where inflammation needs to be controlled.
The active ingredient in Omnacortil 10 Tablet is prednisolone, a synthetic corticosteroid that mimics the action of natural hormones produced by the adrenal glands. Prednisolone works by suppressing overactive immune responses and reducing inflammation in affected tissues. This action helps relieve symptoms such as swelling, redness, itching, and pain, while also preventing damage caused by chronic inflammation. In transplant medicine, it plays an important role in preventing the immune system from rejecting a transplanted organ. In oncology, it may be part of treatment regimens for certain cancers, such as leukaemia and lymphoma, where immune suppression is beneficial.
Wysolone 10 tablet is another brand that contains prednisolone as its active component. Both Omnacortil and Wysolone work in the same way and are generally interchangeable when prescribed by a doctor. The choice between brands often depends on availability, patient tolerance, and prescribing preference. To achieve the best results, prednisolone should be taken exactly as prescribed, at the correct dose and time, and for the full duration advised by the doctor. Sudden discontinuation is not recommended, as it can lead to withdrawal symptoms, a flare-up of the underlying condition, or adrenal insufficiency due to the body’s reduced natural steroid production.
While taking prednisolone, it is important to follow certain precautions. Live vaccines should be avoided because the medicine can weaken the immune response, making the vaccine less effective and increasing the risk of infection. Patients should inform their healthcare provider about all other medicines they are taking, including over-the-counter drugs, herbal remedies, and supplements, as prednisolone can interact with many medications, including those for diabetes, blood pressure, blood thinning, and fungal infections. Regular monitoring of blood sugar, blood pressure, weight, and bone health may be recommended during long-term therapy.
Prednisolone can cause side effects, especially when used for extended periods or at high doses. These may include increased appetite, weight gain, mood changes, higher susceptibility to infections, indigestion, and changes in skin appearance. Long-term use may increase the risk of osteoporosis, high blood pressure, cataracts, glaucoma, and hormonal imbalances. Therefore, patients should be closely supervised by their healthcare provider, and the lowest effective dose should be used for the shortest possible time. A healthy lifestyle, including a balanced diet, sufficient calcium and vitamin D intake, regular exercise, and stress management, can help reduce some of the potential risks associated with corticosteroid therapy.
Uses
- For the treatment of allergies, inflammation and rheumatic disorders associated with various organs.
- For the treatment of a certain type of cancer and infections (with appropriate chemotherapy).
- To prevent organ rejection during organ transplant procedures.
Contraindications
- If you are allergic to prednisolone, any other steroids or any other ingredients of this medicine.
- If you have any other infection and you are not taking any medicine to treat that infection.
- If you are suffering from a viral infection of the eye caused by the herpes virus.
Side effects
- Irritation
- Feeling angry
- Mood swings
- Confusion
- Anxiety
- Infections
- Bloating
- Weakness
- Fatigue
Precautions and Warnings
Alcohol
Although there is no known interaction with alcohol, it is important to consult your doctor if you drink alcohol too often.
Pregnancy
Omnacortil 10 Tablets should not be used during pregnancy as it may affect the growth of the foetus. Cases of cataracts have been also observed in babies born of mothers taking steroids for the long term. Thus, it should be taken only when a doctor recommends after assessing the benefits of this medicine to pregnant women outweighs the risks to an unborn baby.
Breastfeeding
This medicine passes into breast milk. Thus, the use of this medicine is not recommended in breastfeeding mothers unless prescribed by a doctor.
Driving
It has no influence on your driving ability.
Other General Warnings
- You experience any skin allergies and a rise in blood sugar levels, or you are diabetic.
- You experience mood disturbances, fits and other psychiatric problems, including suicidal thoughts.
- You experience visual disturbances and eye infections. Upon long-term use, there is a probability that you may develop a cataract.
- You are elderly, you have a heart problem, high blood pressure and cholesterol, blood clotting problems, liver and kidney diseases.
- It can impair the fertility of an individual; be very cautious.
- You have a history of muscle weakness due to steroid therapy or have a condition called myasthenia gravis.
- This medicine makes you more prone to infections. If you already have an infection, such as a fungal infection, or if you have measles or chickenpox, and you are taking medicines to suppress your immune response, discuss your condition with a doctor.
- Children and adolescents receiving steroids should be observed for growth abnormalities as steroids can retard growth.
Doctor’s suggestion

Directions for use
- Omnacortil 10 tablets should be taken as directed by your doctor. Swallow it whole with a glass of water.
- Take it at a fixed time for optimal results. Do not consume it more than that prescribed by your doctor. Do not stop taking this medicine on your own.
- Omnacortil should be taken exactly as prescribed by your physician at the recommended time (morning, afternoon, or night). It may be taken on an empty stomach, before a meal, or after a meal, as advised. Ensure you follow your routine and complete the full course.
Storage and disposal
- Store this medicine below 25°C.
- Keep it in its original packaging to protect it from catching moisture.
- Keep it out of the reach of children.
Quick tips
- You should avoid taking any live vaccines while taking this medication because they can reduce the vaccine's effectiveness. It is also critical to inform your doctor about all current medications and your complete medical history.
- Use it no more frequently or for any length of time than your doctor has prescribed.
- Stopping Omnacortil 10 Tablet DT suddenly without first consulting your doctor may worsen your symptoms.
- Omnacortil 10 Tablet DT can make it more difficult to fight infections. If you have any signs of infection, such as a fever or sore throat, call your doctor.
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References
- EMA. SmPC. Prednisolone. [ Accessed on 23.March.2021 ] (online)
- CDSCO. Prednisolone. [ Accessed on 23.March.2021 ] (online)
- Lactmed. Prednisolone. [ Accessed on 23.March.2021 ] (online)
- U.S. Food and Drug Administration. Prednisolone acetate [Internet]. Silver Spring (MD): U.S. Food and Drug Administration; 2010 Mar. [cited 2024 Dec 23].
- National Center for Biotechnology Information (2026). PubChem Compound Summary for CID 5755, Prednisolone. Retrieved May 18, 2026
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