Metoclopramide
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Molecule Description
Metoclopramide belongs to Dopamine-Receptor Antagonist that is used to treat mostly for stomach and oesophageal (food pipe) problems.
Uses
- To treat and prevent the slow emptying of the stomach in some conditions such as in diabetic gastroparesis
- To prevent heartburn caused by gastroesophageal reflux disorder (a situation in which acid from the stomach comes into the food pipe)
- To prevent and treat nausea and vomiting
Contraindications
When should one not use Metoclopramide
- Allergic reaction to Metoclopramide
- You have bleeding, obstruction or a tear in your stomach or gut
- Confirmed or suspected adrenal tumor (pheochromocytoma)
- History of involuntary muscle spasms (tardive dyskinesia)
- Fits (epilepsy)
- Parkinson's disease
- If you are on a medicine for Parkinson's disease called Levodopa
- History of abnormality in blood pigment (methemoglobinemia)
Side effects
Common side effects of this drug are:
- Drowsiness
- Weakness
- Headache
- Dizziness
- Diarrhea
- Breast enlargement or discharge (men and women)
- Missed menstrual period
- Decreased sexual ability
- Frequent urination
- Serious side effects are tightening of the muscles, especially in the jaw or neck, speech problems, depression, muscle stiffness, confusion, fast, slow or irregular heartbeat, sweating, restlessness, nervousness or jitteriness, agitation, difficulty falling asleep or staying asleep, foot-tapping, slow or stiff movements, uncontrollable shaking of a part of the body, difficulty keeping your balance, rash, hives, swelling of the eyes, face, lips, tongue, hands, feet, ankles, mouth, throat, arms or lower legs, sudden weight gain
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have heart problems
- You have abnormality with the levels of salts in your blood such as potassium, sodium and magnesium
- You have liver or kidney problems
- Do not take this medicine more than three months
Mode of Action
How Does It Work?
It increases stomach and intestinal motility. This speeds up the process of food emptying from the stomach into the intestine.
Interactions
Interactions with other medicines
- Fluoxetine (medicine for depression treatment)
- Low strength Aspirin
- Ondansetron and Vitamin D3
- Levodopa and Parkinson’s medicine
- Digoxin (medicine for heart failure treatment)
Interactions with food items
No known food interaction.
Dosage
Overdose
Inform your doctor immediately in case of overdose. Symptoms of overdose may include drowsiness, confusion, seizures, unusual, uncontrollable movements, lack of energy, bluish coloring of the skin, headache, shortness of breath.
Missed a Dose
If you missed any dose, take it as soon as you remember. If the time for the next dose is near, skip the missed dose & do not take extra medicine to compensate for the missed dose.
Frequently Asked Questions (FAQs)
Articles
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References:
- medicineplus.metoclopramide. [Accessed 27.Jun.2019] (online)
- Ema.metoclopramide. [Accessed 27.Jun.2019] (online)
- Webmed.metoclopramide. [Accessed 27.Jun.2019] (online)
- Lactmed.metoclopramide. [Accessed 27.Jun.2019] (online) Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Metoclopramide. [Updated 2018 Oct 31].
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