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Lithium

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Molecule Summary

Uses
Treatment of Bipolar disorder, Mental disorders, Aggressive behaviour
Therapy
Anti-Manic
Side Effects
Tremor, Slurred speech, Uncoordinated body movements, Nausea, Acne, Increased white blood cell count, Memory impairment, Hair loss, enlarged thyroid gland, Skin rash, Increased thirst, Weight gain, Polyuria, diarrhoea
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Molecule Description

Lithium is a medicine used to treat bipolar disorder and certain other mental health conditions, including aggressive behaviour.

Uses

  • Bipolar disorder
  • Mental disorders
  • Aggressive behaviour

Contraindications

When should one not use Lithium

  • If you have a medical condition such as dehydration or diarrhoea (loose motions)
  • If you have heart disease, kidney disease, hyperthyroidism or hypothyroidism
  • If you have a mental health condition such as dementia.
  • If you have suicidal tendencies

Side effects

Common side effects of this drug are:

  • Tremor
  • Slurred speech
  • Uncoordinated body movements
  • Nausea
  • Acne
  • Increased white blood cell count
  • Memory impairment
  • Hair loss
  • Enlarged thyroid gland
  • Skin rash
  • Increased thirst
  • Weight gain
  • Polyuria
  • diarrhoea

Precautions and Warnings

Pregnancy

Pregnancy

Lithium is risky to use during pregnancy as there is evidence of risk to the baby. Your doctor may prescribe it in life-threatening situations only if the benefits outweigh the possible risks. Therefore, always discuss with your doctor before starting this medicine.

Breast Feeding

Breast Feeding

Avoid breastfeeding while taking Lithium as it may pass into breast milk and harm the baby.

Driving

Driving

Lithium may cause side effects that affect your ability to drive. It may make you feel tired, sleepy or dizzy. It may also cause effects that can make driving hazardous, such as paralysis, weakness, numbness or seizures.

Alcohol

Alcohol

Avoid alcohol while taking Lithium as it may cause side effects such as dizziness, drowsiness and difficulty concentrating.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • Do not use this medicine if you are allergic to lithium carbonate.
  • Discuss with your doctor before using this medicine if you have heart disease, liver or kidney disease, or drug or alcohol addiction.
  • Take this medicine under the supervision of your doctor.
  • To prevent a side effect reaction, consult your doctor if you are already taking other medicines.

Mode of Action

How Does It Work?

Lithium works by stabilising the unstable activity of nerve cells in the brain. It improves the action of chemical messengers in the brain, preventing the excessive and unusual activity of nerve cells and regulating a person's mood.

Interactions

Interactions with other medicines

  • Lithium may interact with:
  • High blood pressure-lowering drugs like Ramipril
  • Painkillers like ibuprofen and diclofenac
  • Antipsychotic drugs
  • Heart-related medications such as sotalol
  • Antidepressants
  • Antibiotics

Interactions with food items

  • Lithium may interact with caffeine. Caffeine intake, whether coffee, tea or herbal products, may reduce the effect of Lithium.
  • Avoid alcohol as it may increase side effects such as drowsiness, dizziness or problems with concentration.

Dosage

Overdose

Do not take more than the prescribed dose. Lithium overdose can be serious; seek emergency medical help immediately if you think you have taken too much.

Missed a Dose

If you forget a dose of Lithium, take it as soon as you remember. Skip the missed dose and return to your regular schedule if it is nearly time for your next dose.

Frequently Asked Questions (FAQs)

Lithium is not suggested for patients with hypothyroidism (underactive thyroid) as it may increase the risk of low thyroid hormone levels. So, if you have hypothyroidism, notify your doctor before taking Lithium. Thyroid levels are usually tested before starting treatment so that if the levels are too low, Lithium is not prescribed.

Yes, Lithium may cause weight gain, but not everyone taking it will experience this side effect. To avoid gaining weight while taking Lithium, you are advised to exercise regularly and avoid high-calorie drinks. Rather, take non-alcoholic beverages, herbal tea and lemon water.

Yes, Lithium may cause dehydration, particularly if you have low sodium in the body or drink too much alcohol. If you notice dark, strong-smelling urine or a reduction in urination, it suggests that you are dehydrated, which may affect lithium levels in the blood. Accordingly, you are advised to drink plenty of fluids while taking Lithium to prevent dehydration.

Yes, Lithium may cause kidney problems. It is not prescribed for patients who already have severe kidney damage. Before starting treatment with Lithium, your doctor will arrange blood tests to check that your kidneys work normally. While taking Lithium, any gradual or sudden changes in kidney function, even within the normal range, may indicate the need to review the therapy.

Yes, Lithium can cause nervous system effects such as tiredness, dizziness and feeling frightened. It can also affect eye movements, or cause blurred vision or blind spots in your eyesight. If you experience any of these, discuss them with your doctor. Avoid driving or operating heavy machinery as it can be dangerous.

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