Spasmo Proxyvon Plus Capsule
8 Capsule(s) in StripWe do not sell this product
Made by
WOCKHARDT LIMITED
Dosage
CAPSULE
Expiry
Product Summary
| Salt Content | Tramadol(50.0 Mg)+Dicycloverine / Dicyclomine(10.0 Mg)+Paracetamol / Acetaminophen(325.0 Mg) |
| Uses | Moderate to severe acute pain management |
| Therapy | Analgesic for severe pain, anti-spasmodics |
| Side effects | Nausea, Dizziness, Dry mouth, Blurred vision, Indigestion, abdominal pain, Constipation, Headache, Confusion, Difficulty in urination, Seizures, Heart palpitations, Itching, Sleepiness (somnolence), Rashes |
Assurance
available
Regulated
Medical Description
Spasmo Proxyvon Plus is a prescription medication that is a potent painkiller used in the management of moderate to severe acute pain. It combines three drugs, each of which works differently to decrease pain. The drugs in this medication include Tramadol (50mg), Dicycloverine/Dicyclomine (10mg) and Paracetamol (325mg).
Tramadol belongs to a group of drugs called opioids, which act on the brain to produce effects to decrease pain, otherwise known as analgesia. Certain chemical messengers in the brain, called neurotransmitters, signal pain. Opioid drugs decrease the release of these neurotransmitters like glutamate and substance P. This produces a significant decrease in the amount of pain the user perceives.
Dicycloverine/Dicyclomine is an anticholinergic drug that essentially acts on smooth muscle nerve endings to cause muscle relaxation. Hence it acts as an anti-spasmodic. This drug, in particular, acts on the smooth muscles of the digestive tract, treating spasms of the intestine.
Paracetamol is commonly used for fever and as a painkiller. It works by inhibiting cyclooxygenase enzymes that are indicated in inflammation and pain.
This medication is a potent combination used for the treatment of moderate to severe acute pain. As it contains an opioid drug, this medication has tendencies to form habits/addictions and is therefore indicated only for use over a short period of time. It also has potential for misuse and hence careful use of this medication is important.
Uses
- Moderate to severe acute pain
- Headache
- Toothache
- Muscle pain and cramps
- Abdominal cramps
Contraindications
- Hypersensitivity to any of the drug components
- Known or suspected gastrointestinal obstruction, including paralytic ileus
- Concurrent use of monoamine oxidase inhibitors (MAOIs) or use within last 14 days. Examples include Selegiline, Rasagiline.
- Concomitant use of this medication with alcohol can be life-threatening, resulting in respiratory depression, coma and even death.
- This drug is contraindicated in children <12 years
- It is contraindicated for postoperative management in children <18 years following tonsillectomy and/or adenoidectomy
- Severe/acute bronchial asthma in an unmonitored setting or in absence of resuscitative equipment.
- Significant respiratory depression
- Closed-angle glaucoma
- Myasthenia gravis
- Haemorrhage
- Intestinal atony of elderly/debilitated patients
- Obstructive uropathy
- Severe ulcerative colitis
- Reflux esophagitis
- Infants aged <6 months (reports of seizure, respiratory failure, death)
- Severe active liver disease
- This drug can cause serotonin syndrome when used with other drugs that increase the level of serotonin in the brain; this condition is potentially life-threatening.
Side effects
- Nausea
- Dizziness
- Dry mouth
- Blurred vision
- Indigestion, abdominal pain
- Constipation
- Headache
- Confusion
- Difficulty in urination
- Seizures
- Heart palpitations
- Itching
- Sleepiness (somnolence)
- Rashes
- Very rarely, serious skin reactions like Steven Johnson Syndrome and Toxic Epidermal Necrolysis that require immediate intervention and can even be fatal
- Cautions for using this medication:
- Serious, life-threatening, or fatal respiratory depression has been reported; also occurred in children treated with tramadol
- Usage of this drug exposes users to risks of addiction, abuse, and misuse
- Caution in liver/kidney impairment
- Caution in elderly patients with prostate enlargement (BPH)
- Caution in heart failure
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Directions for Use
- This medication should be taken as prescribed by the treating physician.
- Swallow this medication as whole. Do not crush, chew or break this tablet.
- This medication is recommended for use over a short period of time only.
- Driving/ use of heavy machinery are not advised while using this medication.
- Alcohol consumption while on this medication is strictly contraindicated.
Storage and disposal
Store below 30’C. Keep out of reach of children and pets. Keep away from direct sunlight and moisture.
Dosage
Overdose
Overdose with this medication can cause severe respiratory depression, coma and even death. It can cause severe liver and kidney dysfunction as well. In event of a suspected overdose, rush the patient immediately to a tertiary care hospital with ICU facilities for emergency intervention and further management.
This medication has potential for mis-use/abuse and must be used carefully as prescribed by the treating physician.
Missed a Dose
If you miss a dose of Spasmo Proxyvon Plus, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Mode of Action
How Does It Work?
Tramadol belongs to a group of drugs called opioids, which act on the brain to produce effects to decrease pain, otherwise known as analgesia. There are certain chemical messengers in the brain, called neurotransmitters that signal pain. Opioid drugs decrease the release of these neurotransmitters like glutamate and substance P. This produces a significant decrease in the amount of pain perceived by the user. This drug has the potential to cause addiction, and become a substance of abuse, as it can produce euphoric effects in users.
Dicycloverine/Dicyclomine is an anti-cholinergic drug that essentially acts on the nerve endings in smooth muscles to cause muscle relaxation. There is a neurotransmitter called acetylcholine at that acts as a chemical messenger between nerves and smooth muscles. The release of acetylcholine causes the muscle to contract. This drug blocks the action of acetylcholine and hence acts as an anti-spasmodic. Dicyclomine particularly acts on the smooth muscles of the digestive tract, treating spasms of the intestine.
Paracetamol/Acetaminophen is a commonly used anti-fever (antipyretic) and analgesic. It is a non-opioid drug that is given in combination with opioids to treat severe pain. It works by inhibiting the action of enzymes called cyclooxygenase that are indicated in inflammation and pain. During inflammation, multiple different chemical modulators are released, some of which are a group called prostaglandins. The cyclooxygenase enzyme plays an important role in the production of these prostaglandins. By stopping the effect of the enzyme, the drug prevents the prostaglandins from mediating the effects of inflammation, there by acting to decrease pain. It also decreases fever response.
Interactions
Interactions with other medicines
- It is important to give your treating physician a complete list of medications you may be taking at the time of prescription of Spasmo Proxyvon Plus, as this will help them make an appropriate decision.
- Co-administration with CYP2D6 inhibitors (Eg, amiadarone, quinidine) may result in increased tramadol plasma levels and may result in signs and symptoms of opioid withdrawal and reduced efficacy.
- Co-administration with CYP3A4 inhibitors or discontinuation CYP3A4 inducers may result in an increase in tramadol plasma concentrations and toxicities.
- Co-administration of CYP3A4 inducers or discontinuation of CYP3A4 inhibitors may result in lower tramadol levels.
- Co-administration of opioids with benzodiazepines or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.
- Co-administration with serotonergic drugs may increase the risk for serotonin syndrome. Serotonergic drugs include anti-depressants like sertraline, escitalopram, fluoxetine etc.
Interactions with food items
- This medication can be taken with or without food.
Frequently Asked Questions (FAQs)
Articles
View All
Chronic Condition Articles
View All
Did you find this helpful?
Explore More at Pharmeasy
Manufacturer Details
Brand:SPASMO PROXYVON
Manufacturer Name:WOCKHARDT LIMITED
Address:<p>1. Wockhardt Towers, Bandra Kurla Complex, Bandra (East), Mumbai 400051, Maharashtra, India</p>
Country of Origin:India
Vendor Details
Fulfillment Information: Spasmo Proxyvon Plus Capsule will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.
References:
- Tramadol.
- Dicyclomine.
- Gerriets V, Anderson J, Nappe TM. Acetaminophen. [Updated 2021 Jul 3]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from:
- National Center for Biotechnology Information (2021). PubChem Compound Summary for CID 3042, Dicyclomine. Retrieved December 17, 2021 from
In Case of Any Issues Contact Us
Email Id:care@pharmeasy.in
Phone Number:7666100300
Address:D-37/1, Opp. Sandoz, TTC Industrial Area, MIDC Industrial Area, Turbhe, Navi Mumbai, Maharashtra 400703
Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
