Human Mixtard 30/70 100Iu Vial Of 10Ml Suspension For Injection

• Human Mixtard 30/70 100IU is used to control blood glucose in adults and children with type 1 diabetes mellitus.
• Human Mixtard 30/70 100IU is also used in type 2 diabetes when diet, exercise and oral medicines no longer keep blood glucose within the target range, and in other situations where insulin is required.

• If you are allergic to insulin or any of the ingredients of this medicine
• If you are suffering from hypoglycemia (low blood sugar level).

• Low blood sugar (Hypoglycaemia)
• Lightheadedness
• Dizziness
• Anxiety
• Nervousness
• Tiredness
• Feeling hungry
• Visual disturbances
• Headache
• Shaking
• Sweating
• Pale skin
• Skin rashes
• Pain, redness, swelling at injection site.

Other General Warnings

• You have recurrent low blood sugar levels
• Be very careful about symptoms of low blood sugar like sweating, anxiety, fast heartbeat, headache, intense hunger, restlessness, dizziness, irritability. If you experience these, immediately have sugar (Do not consume artificial sweeteners). Eat something as soon as possible. Do not take insulin in such a scenario. If still the symptoms persists, seek emergency medical help
• You have frequent fever and infections
• You have diseases related to liver and kidney
• You have thyroid disorders
• You are switching to different insulin medicine brand
• You have pain, itching and swelling at the injection site, you should continuously change the site of injection
• Avoid doing heavy exercise
• You are planning to change your diet preferences
• You should always carry sugar candy with you
• You are taking insulin but not taking adequate meals, your blood glucose can drop drastically.

• Take this injection as per the technique suggested by your doctor or nurse
• This injection is to be taken under the skin of the thigh or upper arm or abdomen
• Do not take this injection in vein or in muscles
• Pull a skin, fold up to take this injection
• Wait for at least 6 sec before removing the needle from the injection site
• Always rotate the site of injection, do not take concurrent injections at the same site.

• Store between 2°C to 8°C in the refrigerator
• Do not freeze it
• Keep it out of the reach of children
• Do not open the carton of vials to protect it from light
• Any unused portion should not be stored and should be appropriately discarded.

• Roll and tip the vial gently until the liquid is uniformly cloudy before every single dose; never shake it hard.
• Inject about thirty minutes before your meal, and never skip or delay that meal afterwards.
• Rotate injection sites and move at least a finger-width from the last spot to prevent lumps forming under the skin.
• Keep using the same body area for the same time of day, since absorption differs between abdomen, thigh and arm.
• Use a new needle every time and never share needles, syringes or vials with anyone.
• Store unopened vials in the fridge, never in the freezer, and keep the in-use vial at room temperature away from heat and sunlight.
• Discard insulin that is clumped, frosted, discoloured or will not mix evenly.
• Always carry fast-acting sugar and treat a low immediately with about fifteen grams of glucose.
• Check your glucose before driving and never drive when your reading is low.
• Never drink alcohol on an empty stomach, and check your sugar before bed after drinking.
• Do not stop insulin during illness; requirements usually rise, so check glucose more often and seek advice.
• Never change your insulin brand, type or strength without medical supervision.

Overdose

• Excess insulin will lead to low blood sugar levels, called hypoglycemia
• Symptoms like dizziness, fainting, sweating and tremors may be seen
• If you have the blood glucometer with you, test immediately and confirm
• Whether or not you test your levels, it is important to take some glucose water/juice/eat sugar or chocolates immediately and then rush to your doctor.

Missed a Dose

• Missed dose may lead to high blood sugar levels which can cause symptoms like feeling thirsty, excessive urination, loss of appetite, drowsiness, fruity smell from breath, etc.
• If you missed any dose of medicine take it as soon as you remember
• If it's time for your next dose then skip the missed dose and continue with your regular dose schedule
• Do not take a double dose of medicine to compensate the missed one as taking double dose can cause a drastic fall in blood glucose which can be dangerous.

• Insulin is crucial to allow entry of blood glucose into each cell of the body
• Inside the cell, this glucose is used as fuel
• In type 1 diabetes mellitus, the body fails to produce adequate insulin
• This leads to glucose accumulating in the blood and cause high blood glucose
• This medicine lowers blood sugars by stimulating glucose uptake by cells, tissue and muscles, especially by skeletal muscles and fat and by inhibiting glucose production by the liver.

Interactions with other medicines

• You may have symptoms of low blood sugar if you are taking other medicines for diabetes, depression (fluoxetine), medicines for fever and pain (salicylates), ramipril, lisinopril
• You may have high blood sugar if you are taking oral contraceptives, thiazide, steroids, thyroxine, medicines used to treat severe diarrhoea and abnormal growth of body organs like octreotide, lanreotide
• If you are taking a medicine pioglitazone to treat diabetes, be cautious, as some cases of heart attack and heart failure have been reported
• Some medicines block your body's response to low blood sugar, so you may not experience symptoms like headache, hunger pangs, sweating, anxiety when your blood sugar drops. This can lead to a serious fall in blood sugar. Inform your doctor if you are on medicines like Betablockers (Metoprolol, Propranolol, Atenolol), Clonidine, Guanethidine and Reserpine.

Interactions with food items

• Meal timing is part of the treatment with this insulin. Inject about thirty minutes before eating, and never inject and then skip, delay or greatly reduce the meal, as a low blood sugar will follow.
• Keep the carbohydrate content of your meals reasonably consistent from day to day. A much smaller meal than usual for the same dose is a common cause of a hypo.
• Always carry fast-acting sugar such as glucose tablets, sweets or juice. Treat a low with about fifteen grams, wait fifteen minutes, recheck, and then eat a longer-acting snack if your next meal is not due.
• Alcohol should never be taken on an empty stomach. Eat alongside it, keep the quantity modest, and check your glucose before bed, as the risk of an overnight low is real.
• Plan for exercise, which lowers glucose during and for many hours afterwards. You may need extra carbohydrate beforehand or a dose reduction; discuss this with your doctor.
• During illness, do not stop your insulin even if you are eating little. Requirements usually rise with fever and infection. Check glucose more often, take small carbohydrate-containing drinks and contact your doctor for advice.