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Amitone Forte Tablets

10 Tablet(s) in Strip
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Amitone Forte Tablets Description

Amitone Forte is a prescription medication used in the treatment of depression and associated anxiety. It is a combination of two drugs, Amitriptyline (25 mg) and Chlordiazepoxide (10 mg). Amitri

ptyline belongs to a class of medicines called tricyclic antidepressants, and Chlordiazepoxide is a benzodiazepine. The mode of action of Amitone Forte is by affecting multiple brain pathways that regulate mood, personality, and anxiety by targeting chemical messengers called neurotransmitters; hence their use as antidepressants. Depression is a mood disorder characterised by low mood, loss of interest in daily activities, difficulty sleeping, and other features. Anxiety is a condition associated with nervousness and constant thoughts of worry. These conditions are related to altered levels of neurotransmitters in the brain. Directions for use Amitone Forte should be strictly followed. The medication should be taken only after consulting a doctor. It should not be abruptly started or stopped. Taking the tablet at the same time every day is advisable. Side effects of Amitone Forte include constipation, urinary retention, dry mouth, orthostatic hypotension and dizziness, blurred vision, confusion, and increased appetite and weight gain.


Product Summary

Offer Price₹47.74
You Save₹6.51 (12% on MRP)
ContainsAmitriptyline(25.0 Mg) + Chlordiazepoxide(10.0 Mg)
UsesTreatment of major depressive disorder with moderate to severe anxiety
Side effectsConstipation, Urinary retention, Weight gain, Confusion, Orthostatic hypotension (sudden lowering of blood pressure on standing), Tiredness, Blurred vision, Dryness in mouth, Increased heart rate, Uncoordinated body movements, Memory impairment
Check more medicines with composition as Amitriptyline(25.0 Mg) + Chlordiazepoxide(10.0 Mg)

Uses of Amitone Forte Tablets

  • Amitone Forte is used for the treatment of Major Depressive Disorder (MDD) associated with moderate to severe anxiety.

Contraindications of Amitone Forte Tablets

  • Do not use Amitone Forte or use with caution:
  • If you have hypersensitivity reactions to the active or inactive components of this medicine.
  • If you have a history of heart conditions such as irregular heart rhythm or had a myocardial infarction (heart attack) recently.
  • If you have an elective surgery planned; stop this medication before your surgery to avoid the risk of interaction with anaesthetic agents.
  • If you have angle-closure glaucoma; do not use this medicine.
  • If you have any epilepsy/seizure disorders; this medication decreases the seizure threshold; use cautiously.
  • If you have any pulmonary diseases; use this medicine cautiously.
  • If you are pregnant or planning a pregnancy.
  • If you are under 24 years of age; this medication may increase suicidal ideation in this age group.

Side effects of Amitone Forte Tablets

  • Side effects of Amitone Forte include:
  • Constipation
  • Urinary retention (difficulty in passing urine)
  • Dry mouth
  • Sudden lowering of blood pressure on standing up (orthostatic hypotension) and dizziness
  • Blurred vision
  • Confusion
  • Increased appetite and weight gain
  • Long-term use of benzodiazepines can cause tolerance and dependence.

Precautions and Warnings of Amitone Forte Tablets



Can I take Amitone Forte tablets during pregnancy?
No. This medication is a Category D medicine and is unsafe in pregnancy. It should not be taken if pregnant or planning to conceive. Please consult your doctor and inform them regarding your health status.

Breast Feeding

Can I take Amitone Forte tablets while breastfeeding?
This medication is generally not advised while breastfeeding. Discuss your breastfeeding status with your doctor for more information.


Can I drive if I have taken an Amitone Forte tablet?
Driving and operating other heavy machinery while on this medication is not recommended as it may cause sedation and drowsiness.


Can I consume alcohol with Amitone Forte tablets?
Alcohol consumption while on this medication is contraindicated as mixing alcohol with this medication may cause increased sedation and other adverse effects.

Other General Warnings

Talk to your doctor if
  • You should inform your doctor about any other medications you are taking. This tablet interacts with many other medications that use the same metabolic enzymes.
  • You should report to your doctor immediately in case of any discomfort or sudden mood changes.

Mode of Action of Amitone Forte Tablets

How Does It Work?

Amitriptyline belongs to a class of medications called tricyclic antidepressants (TCAs), which act on multiple brain pathways to increase levels of certain chemical messengers called neurotransmitters...
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Directions for Use of Amitone Forte Tablets

  • This medication should be taken as prescribed by the treating physician.
  • It is recommended to take this medication on a regular schedule. Taking the tablet at the same time every day is advisable to get optimal effects and reduce the chances of side effects.
  • Swallow this medication as a whole. Do not crush, chew or break this tablet.
  • It is recommended to finish the entire course of this medication as prescribed by the treating doctor. Abrupt stoppage of the drug can cause withdrawal side effects. Consult your doctor before stoppin...
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  • It can be taken with or without food.
  • Driving or use of heavy machinery is not advised while using this medication.
  • Inform your doctor regarding other medications you may be taking so they can check for potential interactions.

Interactions of Amitone Forte Tablets

Interactions with other medicines

  • This medication affects the heart rhythm. It should not be used with other medications like astemizole and cisapride that also have the same effect. This may result in potentially life-threatening con...
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  • This medication should not be used concomitantly with MAOIs (Monoamine oxidase inhibitors) or within 14 days of the use of MAOIs and vice versa. Examples of MAOIs include selegiline and rasagiline.
  • This medication should not be used with other medicines like isocarboxazid, which increases serotonin levels. This may result in a potentially fatal condition.
  • This medication should not be used with other CNS depressants.
  • This medication should not be mixed with other benzodiazepines.

Storage and disposal of Amitone Forte Tablets

Store in a cool and dry place, away from direct light and moisture. Do not use the medicine after the date of expiration. Keep the tablets away from children and pets. Do not flush the medication down...
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Dosage of Amitone Forte Tablets


Overdose of Amitone Forte may cause sedation, seizure, coma, increased heart rate, low blood pressure, dilated pupils, dry mouth, and difficulty in passing urine or stools. In case of a suspected over...
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Missed a Dose

If you have missed a single dose of the Amitone Forte tablet, take it as soon as you remember. If you recall missing a dose when it's almost the time to take the next dose, skip the missed dose and co...
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Content Details


Dr. Bhavika Shah

MBBS, MD (Dermatology), DNB (Dermatology)

Frequently Asked Questions (FAQs)


Q: I have been using Amitone Forte tablets for a couple weeks now, but feel the same. Should I increase the dose?

A: Amitone Forte can take 4 to 6 weeks for efficacious pharmacological action. Do not increase the dose without the express prescription of your treating doctor.

Q: I have been using Amitone Forte tablets and feel better now. Can I stop taking it?

A: Abrupt stoppage of Amitone Forte tablets may result in withdrawal symptoms that can be debilitating. Discuss with your doctor for more information on tapering and stopping the medication if indicated.

Q: I started taking Amitone Forte five days back. I am unable to sleep after taking the tablet. Should I stop taking it?

A: Insomnia or difficulty sleeping is commonly seen after starting this medication, especially in the first week. Consult your doctor for the same. Do not abruptly stop the medication.
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Last Updated on: 25 Feb 2022 | 10:20 AM (IST)
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