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Amitriptyline+Chlordiazepoxide

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Molecule Summary

Uses
Depression, anxiety.
Therapy
Anti-Depressant
Side Effects
Tiredness, constipation, nausea.
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Molecule Description

Amitriptyline+Chlordiazepoxide is used to treat depression and anxiety. It is also used in the treatment of symptoms of alcohol withdrawal and bedwetting in children. This medicine contains Amitriptyline and Chlordiazepoxide as its prominent ingredients.

Uses

  • Depression
  • Nighttime bedwetting in children
  • Anxiety
  • Insomnia
  • Alcohol withdrawal symptoms

Contraindications

When should one not use Amitriptyline+Chlordiazepoxide

  • Elderly people
  • A child who is below 12 years of age
  • Hypersensitivity to this medicine
  • Cisapride users
  • Monoamine oxidase inhibitor users
  • Cardiovascular disorders
  • Sedative users
  • Allergies to any constituents of the medicine
  • Bipolar disorder

Side effects

Common side effects of this drug are:

  • Common side effects:
  • Weight gain or weight loss
  • Drowsiness
  • Constipation
  • Mental confusion
  • Increase in heart rate
  • Fatigue
  • Orthostatic Hypotension (Blood pressure falls suddenly while standing)
  • Skin Rash
  • Diarrhoea
  • Headache
  • Vomiting
  • Nausea
  • Mild side effects subside on their own.
  • Serious side effects
  • Unusual mood changes
  • Suicidal thoughts
  • Myocardial infarction
  • Tremor
  • Liver Failure
  • Impotence
  • Hallucination
  • Coma
  • Delusions
  • Fainting
  • Nightmares

Precautions and Warnings

Pregnancy

Pregnancy

No. You should not take Amitriptyline+Chlordiazepoxide during pregnancy since it may cause harm to the foetus.

Breast Feeding

Breast Feeding

No. Amitriptyline+Chlordiazepoxide is unsafe while breastfeeding. This drug may harm the baby's health. It may pass through the breastmilk to the baby's body.

Driving

Driving

It is not advisable to indulge in tasks like driving if you have consumed Amitriptyline+Chlordiazepoxide. Its potential side effects include drowsiness and confusion.

Alcohol

Alcohol

No. This medicine should not be taken with alcohol. Consuming this medicine with alcohol may increase the side effects like drowsiness and sleepiness.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You get suicidal thoughts while taking this medicine.
  • You notice a rise in blood sugar levels.
  • Amitriptyline+Chlordiazepoxide can affect blood sugar levels. You may have to constantly monitor your blood sugar levels.
  • You are planning to get pregnant.
  • Your symptoms persist, or they become worse after taking this medicine for a couple of months.
  • Your side effects continue for a prolonged period.
Other General Warnings

Other General Warnings

Talk to your doctor if
  • Inform your doctor about all other medicines and supplements you are taking.
  • It is advised to regularly monitor your liver functions if you are consuming this medicine for an extended period.

Mode of Action

How Does It Work?

Amitriptyline present in Amitriptyline+Chlordiazepoxide is a tricyclic antidepressant. This medicine elevates the levels of certain chemical messengers in the brain, which regulates the patient's mood and helps in treating depression. Chlordiazepoxide is a benzodiazepine that enhances the calming action of a brain chemical (GABA), which helps relieve anxiety.

Interactions

Interactions with other medicines

  • Opioids
  • Antihypertensives
  • Phenylephrine
  • Fluoxetine
  • Aspirin
  • Acetaminophen
  • Clonidine
  • Carbamazepine
  • Barbiturates
  • Adrenaline
  • Buprenorphine
  • Cimetidine

Interactions with food items

  • There are no known food interactions of Amitriptyline+Chlordiazepoxide.

Dosage

Overdose

Inform the doctor immediately if you have taken an overdose of this medicine since it may lead to severe side effects. Symptoms may include enlarged pupils, hallucinations, fast or irregular heartbeat and fever.

Missed a Dose

If you miss a dose of Amitriptyline+Chlordiazepoxide, then take it as soon as you remember. If it is time for your next dose, skip that dose and continue with your routine schedule. Don't take an overdose to compensate for your missed dose.

Frequently Asked Questions (FAQs)

You may have to wait for 1 to 2 weeks to see the effect of this medicine. The complete effect can be seen only after 4-6 weeks. Some patients may feel better sooner. That depends on the individual.

No. Your doctor will make a decision on stopping the medicine. Your doctor may reduce the dose gradually before stopping the medicine.

No. Amitriptyline+Chlordiazepoxide has the potential to cause heatstroke. Avoid spending long hours in the sun after taking this medicine.

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