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Rosuvastatin

Molecule Description

Rosuvastatin belongs to the statin family of medicines which are used to decrease the bad cholesterol, also known as Low-Density Lipoprotein (LDL) in the body.

Uses of Rosuvastatin

It is used in patients with high cholesterol levels, heart disease and high blood pressure. It is known to prevent stroke and reduce the risk of a heart attack.

Contraindications of Rosuvastatin

When should one not use Rosuvastatin

  • Any liver or kidney problems
  • Abnormal liver tests
  • Breastfeeding
  • Allergic to Rosuvastatin
  • Addiction to alcohol
  • If you are taking a medicine called Cyclosporin

Side effects of Rosuvastatin

Common side effects of this drug are:

  • Common side effects are headache, stomach pain, dizziness, heartburn, constipation and nausea
  • Serious side effect includes myopathy, which can manifest in the form of muscle ache, lethargy and fever
  • The patient should immediately report to the treating doctor if any signs of blood in the urine, along with muscle pain, is observed. It can cause jaundice and can elevate liver enzymes. Liver function tests have to be monitored
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  • Abnormal muscle breakdown (rhabdomyolysis) is a condition with severe muscle pain, soreness and may be associated with fever. This can be serious as it is related to the breakdown of muscles leading to acute kidney failure
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  • Promptly report to your doctor if you find dark-colored urine, fever, muscle pain

Precautions and Warnings of Rosuvastatin

Pregnancy

Q:
Can I take Rosuvastatin during pregnancy?
A:
Do not take Rosuvastatin if you are pregnant or if you are planning pregnancy. Taking Rosuvastatin in pregnancy can be harmful to the foetus. Women of childbearing age should use effective contraceptive while using this medicine.

Breast Feeding

Q:
Can I take Rosuvastatin while breastfeeding?
A:
A small amount of this medicine passes into breast milk. Limited data is available on safety about Rosuvastatin during breastfeeding. It is unsafe to consume this medicine if you are planning to breastfeed the baby.

Driving

Q:
Can I drive if I have consumed Rosuvastatin?
A:
Rosuvastatin does not affect the ability to drive.

Alcohol

Q:
Can I consume alcohol with Rosuvastatin?
A:
You must reduce the intake of alcohol while on Rosuvastatin medication, which otherwise can lead to liver damage.

Other General Warnings

Talk to your doctor if
  • You are taking or have taken in the last seven days a medicine called Fusidic Acid (an antibiotic for bacterial infection). Fusidic Acid and Rosuvastatin should not be taken together as they lead to serious muscle problems
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  • You have kidney or liver problems
  • You have muscle aches or pains or family history of muscle problems
  • If in the past you had muscular problems during treatment with other cholesterol-lowering medicines
  • If you regularly drink alcohol

Mode of Action of Rosuvastatin

How Does It Work?

Cholesterol is made by an enzyme HMG-CoA reductase. Rosuvastatin inhibits this enzyme, thus lowering cholesterol and bad cholesterol (LDL) levels. It increases the good cholesterol, also known as high-density lipoprotein (HDL) levels.
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Interactions of Rosuvastatin

Interactions with other medicines

  • Increased risk of myopathy, when used with other lipid-lowering agents
  • Monitor lipid levels to ensure the lowest necessary dose of Rosuvastatin is used when given along with Amiodarone, Diltiazem or Verapamil
  • Many drugs like Cyclosporin, Warfarin, oral contraceptive pills, Itraconazole, Ketoconazole, Erythromycin, Clarithromycin, Telithromycin and HIV protease inhibitors have important interactions reducing the levels of statins
    read less
  • After taking Rosuvastatin within two hours, any antacids like aluminum hydroxide should not be taken
  • Rosuvastatin should not be taken along with Fusidic acid or within 7 days of stopping Fusidic acid as it will lead to a severe side effect of muscle breakdown (rhabdomyolysis)

Interactions with food items

Limit intake of grapefruit juice to minimal quantities.

Dosage of Rosuvastatin

Overdose

Although no particular side effects of overdose of Rosuvastatin are known, one must avoid overdose of any medicine. However, you may see the common side effects of Rosuvastatin in case of an overdose.

Missed a Dose

If you miss a dose of Rosuvastatin, take it as soon as you remember. However, do not take two dosages of Rosuvastatin within 12 hours gap between two doses.

Content Details

WRITTEN BY
doctor

Dr. Abhishek B L

MBBS, MD (Pharmacology)

REVIEWED BY
doctor

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

^

Q: How soon will Rosuvastatin work?

A: You may see results for lowering LDL cholesterol in 2–4 weeks after starting the medication of Rosuvastatin. Results may vary between individuals. On follow-up visits, your doctor may choose to adjust your dosage to help you reach your cholesterol goal.

Q: What are the precautions to follow?

  • These medicines are a part of a comprehensive program to reduce cholesterol levels. Avoid eating foods with high-fat content and exercise regularly for optimum results
  • Tell the doctor if you are pregnant or breastfeeding
  • Tell the doctor if you have any liver/ kidney ailment

Q: What if my daily schedule interferes with the dosage of medicine?

A: Try to take your dosages at the same time every day. Try connecting your dose with something you do every day, such as brushing your teeth or eating breakfast. This may help you remember to take it. Keep a daily calendar or set an alarm clock to go off at the time you need to take your medicine. You can also use a pillbox with the days of the week on it.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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Disclaimer
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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