Metoclopramide

Molecule Description

Metoclopramide belongs to Dopamine-Receptor Antagonist that is used to treat mo

stly for stomach and oesophageal (food pipe) problems.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Metoclopramide

To treat and prevent the slow emptying of the stomach in some conditions such as in diabetic gastroparesis
To prevent heartburn caused by gastroesophageal reflux disorder (a situation in which acid from the stomach comes into the food pipe)
To prevent and treat nausea and vomiting

Contraindications of Metoclopramide

When should one not use Metoclopramide

Allergic reaction to Metoclopramide
You have bleeding, obstruction or a tear in your stomach or gut
Confirmed or suspected adrenal tumor (pheochromocytoma)
History of involuntary muscle spasms (tardive dyskinesia)
Fits (epilepsy)
Parkinson's disease
If you are on a medicine for Parkinson's disease called Levodopa
History of abnormality in blood pigment (methemoglobinemia)

Side effects of Metoclopramide

Common side effects of this drug are:

Drowsiness
Weakness
Headache
Dizziness
Diarrhea
Breast enlargement or discharge (men and women)
Missed menstrual period
Decreased sexual ability
Frequent urination
Serious side effects are tightening of the muscles, especially in the jaw or neck, speech problems, depression, muscle stiffness, confusion, fast, slow or irregular heartbeat, sweating, restlessness, ...
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Precautions and Warnings of Metoclopramide

Pregnancy

Can I take Metoclopramide during pregnancy?

There is limited data on the safety of this medicine in pregnancy. During pregnancy, this medicine should be used when advised by your doctor.

Breast Feeding

Can I take Metoclopramide while breastfeeding?

Metoclopramide passes into breast milk and can adversely affect the baby. Do not take this medicine if you are breastfeeding.

Driving

Can I drive if I have consumed Metoclopramide?

Driving can be dangerous. Avoid driving as this medicine cause involuntary muscle spasms, drowsiness and impair your ability to drive.

Alcohol

Can I consume alcohol with Metoclopramide?

Metoclopramide when taken along with alcohol can cause excessive drowsiness.

Other General Warnings

Talk to your doctor if

You have heart problems
You have abnormality with the levels of salts in your blood such as potassium, sodium and magnesium
You have liver or kidney problems
Do not take this medicine more than three months

Mode of Action of Metoclopramide

How Does It Work?

It increases stomach and intestinal motility. This speeds up the process of food emptying from the stomach into the intestine.

Interactions of Metoclopramide

Interactions with other medicines

Fluoxetine (medicine for depression treatment)
Low strength Aspirin
Ondansetron and Vitamin D3
Levodopa and Parkinson’s medicine
Digoxin (medicine for heart failure treatment)

Interactions with food items

No known food interaction.

Dosage of Metoclopramide

Overdose

Inform your doctor immediately in case of overdose. Symptoms of overdose may include drowsiness, confusion, seizures, unusual, uncontrollable movements, lack of energy, bluish coloring of the skin, he...

Missed a Dose

If you missed any dose, take it as soon as you remember. If the time for the next dose is near, skip the missed dose & do not take extra medicine to compensate for the missed dose.

Content Details

WRITTEN BY

Dr. Mansi Savla

B. Pharm, PharmD

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: What should I discuss with my healthcare expert before taking this medicine?

A: Give a detailed account of your medical and surgical history. Also, mention to your doctor all the prescription and non-prescription medicines, herbal preparations and nutritional supplements that you may be taking before starting this medication.

Q: What special precautions should I follow?

A: Ask your doctor about the safety in having alcoholic beverages when you are taking Metoclopramide. Alcohol can cause side effects of Metoclopramide.

References

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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