Levosulpiride is an atypical antipsychotic medication used in the treatment of nausea, vomiting, heartburn, schizophrenia, depression, etc.
Uses of Levosulpiride
- Stomach acid reflux (acid moves back into the oesophagus from the stomach)
- Stomach discomfort – loss of appetite, pain, tenderness, heartburn, loose motions, constipation, etc. (dyspeptic syndrome and irritable bowel syndrome)
- Unexplained headache (mostly after meals)
- Nausea and vomiting (associated with anti-cancer medicines) Dizziness
- Depression (feeling low, losing interest, etc.)
- Schizophrenia (thinking and behavioral changes, delusions, hallucination - an affected person loses touch with reality.
Contraindications of Levosulpiride
When should one not use Levosulpiride
- If you have an allergy to Levosulpiride or any of its components
- If you have epilepsy or extreme mood swings (feeling very high (mania) or shallow (severe depression))
- Pheochromocytoma (cancer of the adrenal gland that causes fatal and very high blood pressure. It is present above the kidney and produces hormones like adrenaline that regulate metabolism, blood pressure, etc. and steroids)read less
Side effects of Levosulpiride
Common side effects of this drug are:
- Absence of menstrual periods (amenorrhea)
- Swelling of breasts in men (gynecomastia)
- Changes in sex drive
- Milk discharge from the nipples when not breastfeeding, usually in women (galactorrhea)
- A potentially fatal condition with high fever, fast heart rate and breathing, confusion, sweating, irregular pulse, altered mental state (neuroleptic malignant syndrome)these are rare but serious
Precautions and Warnings of Levosulpiride
Can I take Levosulpiride during pregnancy?
Not recommended if pregnant as Levosulpride can cross the placenta and can harm the unborn baby.
Can I take Levosulpiride while breastfeeding?
It is recommended to avoid breastfeeding while taking Levosulpiride as it can be secreted in breast milk and can harm the baby.
Can I drive if I have consumed Levosulpiride?
Levosulpiride can cause side effects like drowsiness, unintentional movements (dyskinesia), numbness and it is advised not to drive while taking this medicine.
Can I consume alcohol with Levosulpiride?
Alcohol can cause the formation of blood clots when used with antipsychotic medicines. Hence consumption of alcohol while taking Levosulpiride is not recommended.
Other General Warnings
Talk to your doctor if
- You have a history of brain stroke (blocked or ruptured blood vessels in the brain), blood clotting disorders or other ailments of the heart and blood vessels
- This medicine should be used with caution in patients who are suffering from diabetes or if exposed to the risk factors
Mode of Action of Levosulpiride
How Does It Work?
Dopamine is a substance naturally produced in the body which transmits signals in the brain. It is mainly concerned with mood and behavioral changes. The activity of dopamine is increased in depressive disorders and schizophrenia (thought and behavioral disorder). Levosulpiride acts by blocking the action of dopamine and thereby improve depression. In lower doses, Levosulpiride has gut motility improving properties and is used to treat reflux of stomach acid and stomach movement disorders like constipation, loose motions, etc.
Interactions of Levosulpiride
Interactions with other medicines
- Medicines which neutralize stomach acid (such as Sucralfate, aluminium and magnesium-containing antacids)
- The effect of Levosulpiride on stomach and gut motility may be reduced by Atropine, Dicyclomine (anticholinergic agents), Narcotics (cannabis, cocaine, etc.) and painkillers (Ibuprofen, Mefenamic Acid, Diclofenac, Aspirin, etc.)read less
- In any case, remember to inform your doctor about all the medications that you are taking
Interactions with food items
Levosulpiride may interact with food. It is recommended to be taken 15-30 minutes before a meal.
Dietary Restrictions of Levosulpiride
No information is available on dietary restrictions while you are taking Levosulpiride, consult your doctor or pharmacist for further information.
Dosage of Levosulpiride
Accidental overdose in a small amount of Levosulpiride may not be harmful. But high doses can cause sleep disorders, restlessness, involuntary muscle movements, tremors, etc. If you experience any such symptoms, inform your doctor immediately or seek medical attention.
Missed a Dose
Take the missed dose as early as you remember. Skip the missed dose and do not take two doses together to compensate for the missed dose.
Frequently Asked Questions (FAQs)
Q: What should I discuss with my healthcare expert before taking Levosulpiride?
- Inform the doctor about your detailed medical, surgical and allery history
- Inform your physician if you have any of the following conditions:
- Liver disease
- History of gastrointestinal bleeding or intestinal obstruction
- Kidney disease
- Heart disease
- If you are pregnant, lactating or planning a pregnancy
Q: Is there anything else I should know about Levosulpiride?
A: Do not self-medicate or self-adjust the dose with Levosulpiride. Levosulpiride is used to control vomiting mostly in patients on cancer therapy and it is not advised to be taken to reduce vomiting in non-cancer patients. Inform your doctor if you want to stop or need to change the dose. It is advisable to drink plenty of water while taking Levosulpiride.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)
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