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Chlorpheniramine / Chlorphenamine+Phenylephrine+Paracetamol / Acetaminophen

Molecule Description

Chlorpheniramine maleate+Paracetamol+Phenylephrine is a combination medicine. I

t is used to treat the common cold and cough associated with fever. It helps in relieving fever, cough, nasal congestion and allergic symptoms of the nose and throat and airways. Chlorpheniramine is an anti-allergic, paracetamol is an antipyretic and analgesic and phenylephrine is a decongestant. Chlorpheniramine maleate+Paracetamol+Phenylephrine is available in the form of a tablet, capsule, syrup, suspension, oral liquid, oral drops and nasal drops. Before using this medicine, inform the doctor about your detailed medical history.


Uses of Chlorpheniramine / Chlorphenamine+Phenylephrine+Paracetamol / Acetaminophen

Chlorpheniramine maleate+Paracetamol+Phenylephrine is used for the treatment of cough, cold along with fever, nasal congestion and allergic symptoms.

Contraindications of Chlorpheniramine / Chlorphenamine+Phenylephrine+Paracetamol / Acetaminophen

When should one not use Chlorpheniramine / Chlorphenamine+Phenylephrine+Paracetamol / Acetaminophen

  • If you are allergic to chlorpheniramine, paracetamol, phenylephrine or similar medicines.
  • If you are suffering from high blood pressure or heart disorder.
  • If you are pregnant or breastfeeding.
  • If you suffer from any thyroid problem.
  • If you have difficulty in urination due to enlarged prostate.

Side effects of Chlorpheniramine / Chlorphenamine+Phenylephrine+Paracetamol / Acetaminophen

Common side effects of this drug are:

  • Headache
  • Dizziness
  • Nausea
  • Weakness

Precautions and Warnings of Chlorpheniramine / Chlorphenamine+Phenylephrine+Paracetamol / Acetaminophen



Can I use chlorpheniramine maleate+paracetamol+phenylephrine during pregnancy?
Pregnant women should take chlorpheniramine maleate+paracetamol+phenylephrine only if considered essential by the doctor after assessing the benefits over risks. Do not self-medicate.

Breast Feeding

Can I use chlorpheniramine maleate+paracetamol+phenylephrine while breastfeeding?
Chlorpheniramine maleate+Paracetamol+Phenylephrine should be taken while breastfeeding only under the doctor's recommendation.


Can I drive if I have used chlorpheniramine maleate+paracetamol+phenylephrine?
Chlorpheniramine maleate+Paracetamol+Phenylephrine may cause sedation, thus avoid driving after taking this medicine.


Can I consume alcohol after using chlorpheniramine maleate+paracetamol+phenylephrine?
Avoid consuming alcohol while on treatment with chlorpheniramine maleate+paracetamol+phenylephrine.

Other General Warnings

Talk to your doctor if
  • You have heart conditions such as high blood pressure or heart failure problems.
  • You have a kidney or liver problem.
  • You are suffering from diabetes mellitus or hyperthyroidism.
  • You have epilepsy and you experience frequent fits and tremors.
  • You are suffering from an eye condition of increased pressure inside your eyes called closed-angle glaucoma.
  • You experience any skin rashes & allergic symptoms after taking chlorpheniramine maleate+paracetamol+phenylephrine.
  • You have a history of severe allergic reactions.
  • You are taking any other medicines containing paracetamol.

Mode of Action of Chlorpheniramine / Chlorphenamine+Phenylephrine+Paracetamol / Acetaminophen

How Does It Work?

  • Paracetamol inhibits the synthesis of prostaglandins which is responsible for pain and inflammation and also acts on heat-regulating centres and reduces body heat to control fever.
  • Chlorpheniramine acts by blocking the action of histamine, a natural substance produced by the body during an allergic reaction.
  • Phenylephrine is a vasoconstrictor, it shrinks or constricts the blood vessels in the nasal passage and improves congestion.

Interactions of Chlorpheniramine / Chlorphenamine+Phenylephrine+Paracetamol / Acetaminophen

Interactions with other medicines

  • Some medicines can affect the way chlorpheniramine maleate+paracetamol+phenylephrine works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
  • Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interaction.
  • Medicines used to treat brain disorders such as rasagiline, methyldopa, clomipramine, medicines used to relax the airways such as epinephrine, reserpine and medicines used to treat heart conditions li...
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  • Other medicines containing paracetamol or any topical decongestant containing phenylephrine should not be used along with this medicine.

Content Details


Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: In which all dosage forms is Chlorpheniramine maleate+Paracetamol+Phenylephrine available?

A: Chlorpheniramine maleate+Paracetamol+Phenylephrine is available in the form of a tablet, capsule, syrup, suspension, oral liquid, oral drops and nasal drops.

Q: Does Chlorpheniramine maleate+Paracetamol+Phenylephrine cause drowsiness?

A: Yes, Chlorpheniramine maleate+Paracetamol+Phenylephrine may cause drowsiness as a side effect.
Last Updated on: 19 Nov 2021 | 10:55 AM (IST)
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