Zerodol SP Tablet
10 Tablet(s) in StripProduct Summary
Zerodol SP Tablet is a combination medicine containing aceclofenac, paracetamol, and serratiopeptidase. It is used to relieve pain, inflammation, and swelling associated with conditions such as arthritis, muscle injuries, sprains, back pain, dental pain, and post-operative recovery.
Medically Reviewed by Dr. Ambika Dashrathrao Mamde
Last updated on: 13 October 2026 | 1:07 PM (IST)
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General Information
| Therapy | Analgesic/antipyretic, anti-inflammatory |
| Composition | Aceclofenac(100.0 Mg)+Serratiopeptidase(15.0 Mg)+Paracetamol / Acetaminophen(325.0 Mg) Aceclofenac 100.0 Mg+Serratiopeptidase 15.0 Mg+Paracetamol / Acetaminophen 325.0 Mg |
Aceclofenac 100.0 Mg+Serratiopeptidase 15.0 Mg+Paracetamol / Acetaminophen 325.0 Mg

℞Avighna Medicare Pvt Ltd
₹109.03 ₹98.13
₹9.81/Tablet
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*Offer applicable on orders above ₹1000About Zerodol Sp
Zerodol-SP It is primarily used to relieve mild-to-moderate pain, swelling, inflammation, and fever associated with joint and muscle conditions, arthritis, dental pain, and postoperative discomfort.
Zerodol-SP is a prescription drug. It contains Aceclofenac which is a non-steroidal anti-inflammatory drug (NSAID) that blocks, paracetamol, is Analgesic and antipyretic which reduces mild to moderate pain and minor febrile (fever) conditions, and Serrapeptase is promoted as an anti-inflammatory and mucolytic agent
The most common side effects of Zerodol-SP are gastrointestinal, such as nausea, indigestion, stomach pain, and diarrhoea. To avoid these issues, it is important to always take the tablet with food or a glass of milk. You should never take this medicine on an empty stomach. Avoid drinking alcohol while taking Zerodol-SP, as this can severely increase your risk of stomach bleeding and liver damage.
The typical dose for adults is one tablet once or twice daily as directed by a doctor. Never take more than the recommended amount. Zerodol-SP is for short-term use only. If you have a history of stomach ulcers, kidney or liver issues, or are pregnant or breastfeeding, consult your doctor before taking this medication. If your pain persists after a few days, stop taking the tablet and seek medical advice.
Uses
- For tooth Pain and toothache: When you have a toothache, the pain is often caused by inflammation in the gums or the tooth’s pulp. Zerodol-SP for tooth pain works because aceclofenac and paracetamol block the pain signals, while Serratiopeptidase reduces the gum swelling, providing complete relief from the throbbing pain and discomfort.
- Relief from Joint Pain (Osteoarthritis & Rheumatoid Arthritis): Zerodol-SP is widely prescribed to manage the pain and inflammation associated with joint conditions. In osteoarthritis, it helps relieve the pain from cartilage wear and tear. In rheumatoid arthritis, it helps reduce the painful swelling and stiffness in the joints caused by the body’s immune system attacking them(Autoimmmunity).
- Back Pain, Neck Pain, and Spondylitis: For conditions such as lower back pain, a stiff neck, or ankylosing spondylitis, Zerodol-SP provides relief by reducing inflammation in the spine and relaxing the muscles.
- Post-Surgical Pain and Swelling: After a minor surgery or a dental procedure, the body’s natural response is to create inflammation and swelling at the site. The Serratiopeptidase in Zerodol-SP helps to clear away the excess fluid and proteins, reducing swelling and bruising, which in turn speeds up the healing process.
- Pain from Injuries (Sprains and Strains): For sports injuries, sprains, or muscle strains, Zerodol-SP works to alleviate the immediate pain, control the inflammation, and reduce the swelling, helping you recover more comfortably.
Contraindications
- If you have a known allergy or hypersensitivity to aceclofenac, paracetamol, serratiopeptidase, aspirin, or any other NSAIDs (like Ibuprofen), or any of the ingredients of this medicine.
- Do not give this medication to children. It is indicated in adults only.
- If you have a history of asthma attacks, severe skin rashes, or allergic reactions after taking other painkillers.
- If you have an active or a history of frequent stomach ulcers, or have experienced bleeding or perforation in any part of your digestive system, stomach, or intestines.
- If you are in your third trimester of pregnancy.
- If you suffer from severe heart failure, liver disease, or kidney disease.
Doctor’s suggestion

Side effects
- Nausea, vomiting, or diarrhoea
- Stomach pain
- Indigestion
- Heartburn
- Loss of appetite
- Dizziness or headache
- Severe allergic reactions such as rashes, hives, difficulty breathing, or swelling of the face, lips, tongue, or throat
- Bleeding in the stomach
- Black, tarry, or bloody stools
- Coughing up blood or vomit that looks like coffee grounds
- Chest Pain
- Weakness
- Shortness of Breath
- Jaundice (yellowing of skin or eyes)
- Difficulty urinating
- Bloody urine
- Blistering, peeling, or a purple skin rash (e.g., Stevens-Johnson Syndrome)
Precautions and Warnings
Alcohol
WITH CAUTIONYou should strictly avoid consuming alcohol while taking Zerodol-SP. Combining alcohol with NSAIDs like Aceclofenac and Paracetamol significantly increases the risk of stomach bleeding, ulcers, and severe liver damage.
Pregnancy
UNSAFENo, it is not safe to take Zerodol-SP tablet during pregnancy, Always consult your obstetrician before taking any painkillers during pregnancy.
Breastfeeding
UNSAFEIt is generally not recommended to use Zerodol-SP while breastfeeding, as the ingredients can pass into breast milk. It is best to consult your doctor, who can suggest a safer alternative for pain relief.
Driving
WITH CAUTIONIt is best to avoid driving after taking Zerodol-SP. While it doesn't typically cause severe drowsiness, a possible side effect is dizziness, which could impair your ability to drive safely.
Other General Warnings
- You have a history of liver, kidney, or heart conditions.
- You have high blood pressure, asthma, or any bleeding disorders.
- You have a history of stomach ulcers, acidity, or inflammatory bowel disease (like Crohn's disease).
- You are scheduled for any surgery, including dental surgery.
Doctor’s suggestion

Directions for use
- The standard dose of Zerodol-SP tablet is one tablet. Take it once or twice a day as prescribed by your doctor.
- Always take this medicine with food and a full glass of water. This is crucial for protecting your stomach lining from irritation.
- Swallow the tablet whole. Do not crush, chew, or break it, as this can affect how the medicine is released into your body.
- Maintain a consistent time gap between doses as advised by your doctor.
- Use this medicine for the shortest duration necessary to control your symptoms. Do not use it for long-term pain without medical supervision.
Storage and disposal
- Store Zerodol-SP tablets in a cool, dry place at room temperature (below 30°C).
- Keep the medicine in its original strip or container to protect it from direct sunlight and moisture.
- Always ensure the tablets are stored out of the reach and sight of children and pets.
- Do not use the tablets after the expiry date printed on the packaging.
- Dispose of any expired or unused medicine responsibly.
Quick tips
- Always take Zerodol-SP tablet with a meal or a glass of milk to prevent stomach upset and reduce the risk of ulcers.
- Never take Zerodol-SP with other painkillers containing paracetamol or other NSAIDs (like Ibuprofen), as this can lead to an overdose and serious side effects.
- Avoid drinking alcohol while on Zerodol-SP tablet to protect your stomach and liver.
- Zerodol-SP is very effective for toothaches, but it only treats the symptoms, not the underlying cause. You should see a dentist to address the underlying dental issue.
- If you are taking this medicine for more than a few days, your doctor may want to monitor your kidney and liver function.
- Zerodol SP can be used to treat the pain, inflammation, and fever associated with tonsillitis; however, it is a prescription medication that should be taken only as directed by a physician. It is not an antibiotic and will not treat an underlying bacterial infection if present.
- Zerodol SP should be taken exactly as prescribed by your doctor at the recommended best time for you (morning, afternoon, or night). It may be taken on an empty stomach, before food, or after/meal, as advised. Ensure you follow your routine and complete the full course. Your doctor provides the schedule to ensure the medicine works effectively.
Doctor’s suggestion

Dosage
Overdose
Missed a dose
How Zerodol Sp works
- Zerdol‑SP (aceclofenac + paracetamol + serratiopeptidase) works through a complementary triple mechanism: aceclofenac inhibits cyclo‑oxygenase (COX) enzymes, thereby decreasing inflammation and pain at the site of injury; paracetamol acts via its analgesic and antipyretic effects with minimal peripheral anti‑inflammatory action; and serratiopeptidase, breaks down inflammatory proteins and exudates at the affected site, reducing swelling and promoting tissue healing, together providing effective relief of pain, inflammation, and oedema.
- Serratiopeptidase is a unique enzyme that helps clean up the mess left behind by an injury. When tissues are damaged, your body can produce a lot of inflammatory proteins and fluid debris that causes swelling. Serratiopeptidase breaks down this inflammatory proteins and fluid debris allowing the trapped fluid to drain away and reducing the pressure and swelling. This speeds up the entire healing process.
- Together, these three ingredients provide powerful relief by blocking pain signals, reducing inflammation, and actively cleaning up the debris that causes swelling.
Interactions
Drug interactions of Zerodol Sp with other medicine salt
Food interactions
Follow your doctor or pharmacist advice about taking this medicine with food.
Frequently asked questions
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