Combiflam Tablet
20 Tablet(s) in StripProduct Summary
Combiflam Tablet is used to treat headache, toothache, body ache, muscle and joint pain, and fever; Sanofi combines ibuprofen 400 mg with paracetamol 325 mg in this medicine. Both ingredients reduce chemicals involved in pain and fever. Ibuprofen also reduces inflammation through its anti-inflammatory action.
Medically Reviewed by Dr. Krisha R. Marolia
Last updated on: 13 October 2026 | 10:14 AM (IST)
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TABLET
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General Information
| Therapy | Analgesic/antipyretic |
| Composition | Ibuprofen(400.0 Mg)+Paracetamol / Acetaminophen(325.0 Mg) Ibuprofen 400.0 Mg+Paracetamol / Acetaminophen 325.0 Mg |
Ibuprofen 400.0 Mg+Paracetamol / Acetaminophen 325.0 Mg

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*Offer applicable on orders above ₹1000About Combiflam
Combiflam tablet is a commonly used painkiller medication that helps treat various conditions, including headaches, toothaches, body aches, muscle pain, joint pain, and fever. The active ingredients in Combiflam are Ibuprofen and paracetamol. Combiflam works by blocking the release of certain chemical messengers that cause pain, fever, and inflammation (redness and swelling).
It is recommended to take the tablet with or after food to minimise gastric irritation, especially in individuals with sensitive stomachs. Overuse or self-medication without medical supervision is discouraged due to the potential for gastrointestinal bleeding, liver toxicity, and renal complications, particularly in individuals with pre-existing conditions. You should avoid taking additional paracetamol-containing products while on Combiflam to reduce the risk of liver injury. It's essential to adhere to the prescribed dose and not skip any dose.
Before taking it, tell your doctor if you consume a lot of alcohol, use blood thinners, have asthma, or have liver or kidney problems; the dose or suitability of this medicine may be compromised. It is not recommended for children under 12. Special caution should be exercised in the elderly or individuals with conditions like asthma, high blood pressure, heart failure, or autoimmune diseases. Though generally well tolerated, side effects may include nausea, dizziness, vomiting, skin rashes, and in rare cases, serious allergic reactions or gastrointestinal bleeding.
Women who are pregnant or breastfeeding should consult their doctor before using it. Inform your doctor about all other medications you are taking because they may interact with it.
Some other tablets containing ibuprofen and paracetamol are Ibugesic Plus and Flexon tablet.
Uses
Doctor’s suggestion

Contraindications
- If you are allergic to ibuprofen, paracetamol or any other ingredients of Combiflam Tablet.
- If you have a history of an allergic reaction due to painkillers like aspirin, etc.
- If you are taking medicines containing paracetamol, ibuprofen, or other pain medicines.
- If you have a history of ulcers or bleeding in the digestive tract.
- If you have an active clotting disorder or disorders related to the blood supply to the brain.
- If you are experiencing a fluid loss (due to vomiting, diarrhoea, or not drinking enough fluids).
- If you have kidney or liver function problems.
- If you are pregnant (last trimester), it should not be given to children under 12 years of age (<40kgs).
Side effects
- Stomach upset
- Diarrhoea
- Vomiting
- Dizziness
- Skin rashes
- Itching
Doctor’s suggestion

Precautions and Warnings
Alcohol
WITH CAUTIONAvoid consuming alcohol along with Combiflam Tablet.
Pregnancy
UNSAFECombiflam Tablet is not recommended during pregnancy. Always inform your doctor if you are pregnant or plan to become pregnant, and take the Combiflam Tablet under medical supervision if required.
Breastfeeding
UNSAFECombiflam Tablet is not recommended for breastfeeding women. Always inform your doctor if you are breastfeeding your child and take this medicine under medical supervision if required.
Driving
WITH CAUTIONIf you experience dizziness, drowsiness, fatigue and visual disturbances after taking this medicine, avoid driving.
Other General Warnings
- You are an elderly person.
- You have high blood pressure or heart, kidney or liver diseases.
- You develop stomach bleeding and ulcers after taking this medicine.
- You have a history of, or you suffer from, asthma and nasal allergy.
- You suffer from an immune disorder, where the immune system acts against the body tissues.
- You have a hereditary disorder like G6PD deficiency or porphyria (blood disorders).
- You are an alcoholic or had major surgery.
- If you are trying to conceive, you must discontinue this medicine.
- You develop skin allergies like rashes, itching, papules, blisters, etc.
Directions for use
Storage and disposal
- Store this medicine below 30°C.
- Keep Combiflam Tablets out of reach of children and pets.
Quick tips
- Avoid using Combiflam Tablet for an extended period without medical supervision. Exercise regularly to reduce pain and enhance your overall health. Manage stress through techniques such as meditation, deep breathing, or exercise to reduce pain levels.
- Consult your doctor if your condition does not improve after 3-4 days.
- If you are trying to conceive, you must discontinue this medicine.
- Take Combiflam Tablet only once every 6 hours. Do not take more than 3 tablets in a single day.
- Do not take Combiflam Tablet for more than 4 consecutive days without consulting a doctor.
- Combiflam Tablet is not suitable for children under 12 years old or weighing less than 40 kg (if over 12 years old).
Dosage
Overdose
Missed a dose
How Combiflam works
Interactions
Drug interactions of Combiflam with other medicine salt
Food interactions
Frequently asked questions
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Substitutes for Combiflam
References
- Combiflam Tablet [Internet]. Sanofi.in. 2021 [cited 6 November 2021]
- Combiflam [Internet]. Sanofi.in. 2021 [cited 6 November 2021]
- CDSCO [Internet]. Cdscoonline.gov.in. 2021 [cited 6 November 2021]
- Derry CJ, Derry S, Moore RA. Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Database Syst Rev. 2013;2013(6):CD010210. Published 2013 Jun 24.
- Thybo KH, Hägi-Pedersen D, Dahl JB, et al. Effect of Combination of Paracetamol (Acetaminophen) and Ibuprofen vs Either Alone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty: The PANSAID Randomized Clinical Trial. (cited 18 May 2026)
- Derry, C. J., Derry, S., & Moore, R. A. (2013). Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. The Cochrane database of systematic reviews, 2013(6), CD010210.
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