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Proluton Depot 500mg Inj 2ml

2ml Injection in Ampoule
MRP 306.40
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Inclusive of all taxes
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Hydroxyprogesterone(500.0 Mg)
Therapeutic classification
Drugs For Premature Labour Prevention

Medical Description

Proluton Depot 500mg Inj 2ml contains hydroxyprogesterone as its active ingredient and is used in reducing the risk of premature birth in a female who previously has delivered a premature baby. This medicine should be used under medical prescription and for the duration that it is prescribed. Headache, dizziness, nausea, vomiting are a few side effects of this medicine. If you feel the side effects persist or your condition worsens, then contact your doctor immediately. It is essential to inform your doctor about all your medical and surgical history before starting the treatment.
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Uses of Proluton Depot 500mg Inj 2ml

Proluton Depot 500mg Inj 2ml is a manmade form of a female hormone and is used to reduce the risk of premature birth in a female who has already delivered a premature baby in the past.

Contraindications of Proluton Depot 500mg Inj 2ml

  • If you are allergic to hydroxyprogesterone or any other ingredients of Proluton Depot 500mg Inj 2ml.
  • If you had or have problems with your liver like liver cancer, etc.
  • If you have breast cancer or any other hormone cancer.
  • If you have undiagnosed abnormal vaginal bleeding.
  • If you have or had a history of blood clot disorders.
  • If you have jaundice in pregnancy.
  • If you have high blood pressure that is not controlled.

Side effects of Proluton Depot 500mg Inj 2ml

  • Headache, dizziness
  • Fever, tiredness
  • Nausea, vomiting, diarrhoea
  • Pain, swelling, itching at the injection site, injection site lumps
  • Skin rash, itching, redness
  • Urinary tract infection, jaundice
  • Breathing difficulty, chest pain
  • Depression
  • Miscarriage, stillbirth, high blood pressure caused by pregnancy, high blood sugar during pregnancy

Precautions and Warnings of Proluton Depot 500mg Inj 2ml


Can I take Proluton Depot 500mg Inj 2ml during pregnancy?
There is limited information about the use of this injection during pregnancy. Consult your doctor before using this injection.

Breast Feeding

Can I take Proluton Depot 500mg Inj 2ml while breastfeeding?
Components of this injection pass into breast milk in a small amount. Consult your doctor before using this medicine during breastfeeding.


Can I drive if I have consumed Proluton Depot 500mg Inj 2ml?
This medicine may make you dizzy. Avoid driving if you do not feel well or are unable to be alert.


Can I consume alcohol with Proluton Depot 500mg Inj 2ml?
There is limited information about the effects of this medicine on alcohol, but avoid taking alcohol in excessive amounts.

Other General Warnings

Talk to your doctor if
  • You had or have a blood disorder
  • You have problems with your heart or kidney
  • You have diabetes or pre-diabetes
  • You are pregnant and suffer from asthma, fits, migraine, high blood pressure
  • You have had a history of depression
  • You may develop jaundice or high blood pressure
  • You develop any allergic reactions like rash, swelling, itching
  • You are a smoker
  • Proluton Depot 500mg Inj 2ml should not be used to prevent premature birth in women who are pregnant with more than one baby (like twins, triplets). It should also not be used to stop active premature labour
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Mode of Action of Proluton Depot 500mg Inj 2ml

How Does It Work?

Hydroxyprogesterone is a manmade progestin, its mode of action to prevent or reduce premature birth is still not known.

Directions for Use of Proluton Depot 500mg Inj 2ml

  • This medicine will be given in the hospital by your doctor or nurse as an injection. Do not self-inject this medicine.
  • Follow the instructions suggested by your doctor or nurse during the procedure or for aftercare.

Interactions of Proluton Depot 500mg Inj 2ml

Interactions with other medicines

  • Proluton Depot 500mg Inj 2ml may interact with other medicines, discuss with your doctor about all the medicines, supplements or herbal preparations you are taking. Also, you should inform your doctor if you have a planned surgery or vaccination scheduled.
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  • Medicines like cimetidine, ciprofloxacin, halothane, nicotine, bupropion, ketamine should be used with caution as they may alter the effects of this medicine.

Storage and disposal of Proluton Depot 500mg Inj 2ml

  • Store it below 25°C in the original container to protect from light
  • Do not freeze
  • Keep it away from children and pets

Dosage of Proluton Depot 500mg Inj 2ml


This injection will be given to you by a doctor or nurse. Therefore, it is less likely that you may get more or less of this medicine. If you experience any symptoms right after taking this injection, then seek medical help.
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Missed a Dose

You will be monitored by your doctor or nurse on when the injection should be given to you. It is unlikely that the dose will be missed. However, if you think your doctor or nurse might have missed a dose, then inform them.
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Content Details


Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: Can I stop taking Proluton Depot 500mg Inj 2ml on my own?

  • No, you should never stop taking this medicine until advised by the doctor, even if you are feeling good.
  • If you stop taking this medicine, then it may lead to treatment failure.

Q: Can I take this Proluton Depot 500mg Inj 2ml on my own?

A: It is given by medical practitioners only or under the supervision of a medical professional.
Last Updated on: 20 Mar 2021 | 09:46 AM (IST)
The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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