By AJANTA PHARMA LIMITED
15g Cream in Tube
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Ketriplin cream is a prescription medication. It is used for the management of postherpetic neuropathic/nerve pain. It is composed of amitriptyline and ketamine as its main ingredients. The mode of action of Ketriplin cream is by blocking various receptors and blocking the pain signals. Neuropathic pain is a chronic condition caused by several nerve diseases. It may also occur due to an injury or an infection. Managing post-herpetic neuralgia (the burning, stabbing pains, or aches that may last for months or years after a herpes infection) and preventing migraine headaches are the primary uses of Ketriplin cream. It is essential to follow your doctor’s directions for using Ketriplin cream for external application. The pain may return if you stop using it. Ketamine can also cause dependency. However, since this is a topical application, it does not occur with this cream. There are no significant side effects of Ketriplin cream....
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|Contains||Amitriptyline(40.0 Mg),Ketamine(20.0 Mg)|
|Uses||Neuralgia or neuropathic pain|
|Side effects||Itching, swelling, redness, rash, etc., at the site of application|
|Classification||DRUGS FOR PERIPHERAL NEUROPATHY|
Check more medicines with composition as Amitriptyline(40.0 Mg) + Ketamine(20.0 Mg)
Uses of Ketriplin Cream
- Ketriplin cream is used in,
- Management of neuropathic pain (repairs damage to the nerves, which causes pain, tingling, weakness, and burning sensation)
- Management of post-herpetic neuralgia (lowers the pain or ache after a herpes infection)
- Management of any condition with pain occurred due to nerve damage
Contraindications of Ketriplin Cream
- If you have any allergic reaction to amitriptyline or ketamine, avoid taking Ketriplin cream.
- If you are already using similar medications or creams
Side effects of Ketriplin Cream
- Redness at the site of application
- Inflammation or swelling
Precautions and Warnings of Ketriplin Cream
Can I take Ketriplin cream during pregnancy?
No, Ketriplin cream is not recommended during pregnancy. There is limited data on the side effects of this cream on pregnant women and unborn babies. Consult your doctor so they can prescribe other medicines that are safe in pregnancy.
Can I take Ketriplin cream while breastfeeding?
No, Ketriplin cream are usually not recommended during breastfeeding. There is limited information available on this. Some studies showed that this medicine can get transferred through breast milk and cause side effects like drowsiness in babies. If you are breastfeeding, seek medical consultation before taking Ketriplin cream.
Can I drive if I have taken Ketriplin cream?
Yes, Ketriplin cream does not cause any side effects that may affect your ability to drive. However, in case you have an allergic reaction to this cream, it may cause discomfort, so avoid driving in such conditions.
Can I consume alcohol with Ketriplin cream?
There is no information available on the interactions between Ketriplin cream and alcohol. Generally, try to avoid drinking excessive alcohol, which may precipitate the underlying condition causing the pain.
Other General Warnings
Talk to your doctor if
- You are taking other pain medications.
- You have a surgery or a medical/dental procedure planned. Inform your doctor when you apply Ketriplin cream.
- You are going through physiotherapy along with using this cream.
- You are using any herbal or ayurvedic herbs, or supplements
Mode of Action of Ketriplin Cream
How Does It Work?
Ketriplin cream has Amitriptyline and ketamine as its main ingredients. Amitriptyline is a tricyclic antidepressant medicine. It works by blocking the reuptake of chemical substances like noradrenaline and serotonin, neurotransmitters present at the end of the nerve cells in the brain. This makes the effects of these substances last longer. Thus, Ketriplin cream helps in regulating mood and aids in the management of depression. It relieves neuropathic pain by blocking the pain signals from the brain. Ketamine is an anaesthetic medication. It interacts with various receptors such as N-methyl-D-aspartate (NMDA) receptors, opioid receptors, muscarinic receptors, etc. Unlike other general anaesthetic medications, ketamine does not interfere with GABA (gamma-aminobutyric acid) receptors. All this results in profound anaesthetic and hypnotic (a trance-like state in which you have heightened focus and concentration) effects...
Directions for Use of Ketriplin Cream
- Ketriplin cream is for external application only.
- You should apply the Ketriplin cream as prescribed by your doctor.
- Apply this cream at the site of the pain.
- Wash your hands before applying it.
- Use Ketriplin cream only on a clean and dry surface.
- Consult your doctor if the pain has not subsided after using this cream.
- Do not wash the area after applying this cream.
- Avoid applying other ointments or lotions to the same area after using this medicine.
Interactions of Ketriplin Cream
Interactions with other medicines
- Ketriplin cream can be used without any systemic side effects. You can combine it with other treatment options as there are no interactions reported with any other medicines. Please seek medical advice....
Storage and disposal of Ketriplin Cream
Storage: Store Ketriplin cream in a dry place at room temperature. Keep this cream away from sunlight and moisturiser. Keep Ketriplin cream away from children and pets. Disposal: Dispose of this cream carefully. Do not flush unused/expired medication in the toilet. Discard Ketriplin cream properly after use or after the expiration date. Discard Ketriplin cream properly after use or after the expiration date....
Dosage of Ketriplin Cream
There is not much information available on overdose on Ketriplin cream, as it is rare. Repeated application in some cases may lead to allergic reaction or numbness in that area.
Missed a Dose
If you missed a dose of Ketriplin cream, apply it as soon as you recall. If you remember it close to the time of the next scheduled dose, skip the missed Ketriplin cream application. There is no need to overuse the cream to make up for the missed dose....
Frequently Asked Questions (FAQs)
Q: Should I make any lifestyle changes while taking Ketriplin cream?
A: Generally, it is better to make lifestyle changes such as eating well, being active, stopping drinking and smoking, etc. All these changes can also help with the underlying conditions of neuropathic pain.
Q: Can I take Ketriplin cream if I have diabetes?
A: Yes, Ketriplin cream can be used in the treatment of conditions like diabetic neuropathic pain. Your doctor may prescribe it if necessary. In such cases, it is essential to monitor blood glucose levels regularly if they fluctuate.
Q: Does Ketriplin cream cause any side effects if I use it every day?
A: No, since Ketriplin cream is applied topically, the ingredients of this medication do not reach the blood circulation in large quantities. Hence, they do not cause any severe side effects.
- Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ. Amitriptyline for neuropathic pain in adults [Internet]. The Cochrane database of systematic reviews. John Wiley & Sons, Ltd; 2015 [cited 2022 Mar 14].
- Amitriptyline: Medlineplus drug information [Internet]. MedlinePlus. U.S. National Library of Medicine; [cited 2022 Mar 14].
- Kopsky DJ;Keppel Hesselink JM;Bhaskar A;Hariton G;Romanenko V;Casale R; Analgesic effects of topical ketamine [Internet]. Minerva anestesiologica. U.S. National Library of Medicine; [cited 2022 Mar 14].
- MJ; LMECAJSJS. Topical amitriptyline and ketamine in neuropathic pain syndromes: An open-label study [Internet]. The journal of pain. U.S. National Library of Medicine; [cited 2022 Mar 14].
- CDSCO [Internet]. Cdscoonline.gov.in. 2022 [cited 2022 Mar 14].
- HA; A. [mechanisms of action of ketamine] [Internet]. Anaesthesiologie und Reanimation. U.S. National Library of Medicine; [cited 2022 Mar 14].
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