Hifenac-D Tablet
Description
Hifenac D tablet is a combination medicine used to manage and relieve pain and swelling associated with conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and post-surgery inflammation. Its active ingredients are aceclofenac, paracetamol, and serratiopeptidase. This medicine has both analgesic (pain-relieving) and anti-inflammatory properties, making it useful for various acute painful conditions of joints, bones, and muscles. It is important that you take this medicine strictly as advised by your doctor to ensure optimal benefits and to minimize the risk of side effects.
Aceclofenac and paracetamol function by inhibiting the production of a specific chemical substance called prostaglandin, which is known to be responsible for causing pain and inflammation in your body. Serratiopeptidase complements this action by helping to repair damaged tissues and thereby reducing swelling around the affected or infected area. This combined mechanism allows the medicine to tackle both the pain and the underlying swelling.
It is generally advised to be taken with or after meals to prevent stomach upset. It is strictly not recommended for use during the third trimester of pregnancy, as it can potentially harm the developing baby's heart, increase the risk of bleeding, or delay labor. It is also not advised for those who are breastfeeding. Avoid alcohol consumption during the course of treatment, as it may exacerbate liver issues and other side effects. If you experience dizziness after taking this medicine, you should not drive or operate heavy machinery.
Taking this medicine necessitates certain precautions, especially if you have pre-existing conditions such as kidney or liver problems, heart issues like heart failure or high blood pressure, stomach ulcers, or blood disorders. Concomitant use with other medicines should be discussed with your doctor to avoid interactions, particularly with other pain-relief medicines containing paracetamol or aceclofenac, blood thinners, or steroids. Always inform your doctor about all the medicines, supplements, and herbal remedies you are currently taking before starting Hifenac D tablet.
Some other medicines containing similar compositions are Signoflam tablet, Acemiz S tablet, Zerodol SP and Aceclotrue Sp.
Product Summary
| Offer Price | ₹96.55 |
| You Save | ₹28.84 (23% on MRP) |
| Contains | Aceclofenac(100.0 Mg)+Serratiopeptidase(15.0 Mg)+Paracetamol / Acetaminophen(325.0 Mg) |
| Uses | Pain relief |
| Side effects | Nausea, vomiting, stomach upset, indigestion |
| Therapy | ANALGESIC/ANTIPYRETIC |
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Uses
Contraindications
- If you have an allergy to paracetamol, aceclofenac, serratiopeptidase or any of the ingredients of the Hifenac D tablet.
- If you had an allergic reaction such as asthma, skin rashes or runny nose after taking medicines like ibuprofen and aspirin.
- If you have ever experienced severe allergic reactions.
- If you have a history of frequent stomach ulcers or bleeding.
- If you are suffering from any heart diseases like heart failure and high blood pressure.
- If you have problems with kidney and liver function.
- If you are pregnant (especially after the 3rd month of pregnancy).
Side effects
- Stomach ulcers
- Mouth ulcers
- Nausea
- Vomiting
- Dizziness
- Stomach pain
- Constipation
- Diarrhoea
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You have kidney or liver problems.
- You have known medical conditions like asthma, heart problems, high blood pressure, stomach ulcers, autoimmune disorder, etc.
- You are an elderly patient or taking diuretics or have a kidney disorder, then this medicine can increase the risk of kidney failure.
- You are an alcoholic and concomitant use of this medicine can damage the liver.
- You have disorders related to blood like clotting problems and anaemia.
- You have skin rashes & lesions after taking this medicine.
Directions for Use
Storage and disposal
- Store Hifenac D tablets in a cool and dry place, protected from moisture.
- Keep it out of the reach of children and pets.
Quick Tips
Dosage
Overdose
Missed a Dose
Mode of Action
How Does It Work?
- Aceclofenac and paracetamol act by interfering with the production of a chemical substance called prostaglandin which is responsible for swelling and pain.
- Serratiopeptidase acts by repairing the tissues. Thus, decreasing the swelling around the infected area.
Interactions
Interactions with other medicines
- Certain medicines can interfere with the action of Hifenac D or this medicine itself can affect the action of other medicines taken at the same time.
- Always inform your doctor about all the medicine you are taking, which includes all prescribed or non-prescribed herbal medicines, dietary supplements as well as other treatments if you are taking for any disorders....
- In particular, if you are on certain medications like anti-gout medicines, water pills, medicines for brain and heart-related diseases, anti-epileptic medicines, antibiotics like levofloxacin, immunosuppressants like ciclosporin, anti-hypertensive medicines, etc....
- Do not take any other medicines containing paracetamol or aceclofenac as there is a risk of liver damage.
- Increased risk of stomach ulcers or bleeding when Hifenac D is taken with steroids or other pain relief medicines like Aspirin.
- There is a risk of bleeding if you are taking blood-thinning medicines like warfarin and coumarin during the treatment.
Interactions with food items
Content Details
Dr. Arpit Verma
MBBS, MD, CCEBDM Diabetology
Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: I am a diabetic patient. Do I need to take precautions before taking Hifenac D?
Q: Can I take my regular painkillers along with Hifenac D?
Q: I am on Hifenac D for a long time. Do I need to conduct any tests?
Q: Can the Hifenac D tablet be used to relieve a toothache?
Q: Can I take twice the dose of the Hifenac D tablet if my pain does not get cured?
Q: Can the Hifenac D tablet be given to elderly people?
Q: Is Hifenac D a painkiller?
Q: When should I take Hifenac-D?
Q: Is Hifenac D useful for piles?
Q: What combination of medicine is present in Hifenac D?
Q: What are the side effects of Hifenac D?
References
- VOLTANEC SP Tablets (Aceclofenac + Paracetamol + Serratiopeptidase) [Internet]. Ciplamed.com. 2025 [cited 17th Oct 2025]
- CDSCO - Acelofenac-Paracetamol-Serratiopeptidase [Internet]. Cdscoonline.gov.in. 2025 [cited 17th Oct 2025]
- LactMed - Acelofenac-Paracetamol-Serratiopeptidase [Internet]. Ncbi.nlm.nih.gov. 2025 [cited 17th Oct 2025]
- Anadin Paracetamol Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 17th Oct 2025]
- Anadin Paracetamol Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 17th Oct 2025]
- CLANZA CR- aceclofenac tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2025 [cited 17th Oct 2025]
- A randomized, multicentric, comparative evaluation of aceclofenac-paracetamol combination with aceclofenac alone in Indian patients with osteoarthritis flare-up - PubMedPareek A, Chandurkar N, Sharma VD, Desai M, Kini S, Bartakke G. A randomized, multicentric, comparative evaluation of aceclofenac-paracetamol combination with aceclofenac alone in Indian patients with osteoarthritis flare-up. Expert Opin Pharmacother. 2025 [cited 17th Oct 2025]
- Analgesics/Anti-Inflammatory Drugs Preferred Following Implant Placement: A Retrospective Study - PubMed Murthykumar K, Rajasekar A, Kaarthikeyan G. Analgesics/Anti-Inflammatory Drugs Preferred Following Implant Placement: A Retrospective Study. J Long Term Eff Med Implants. 2025 [cited 17th Oct 2025]
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