Signoflam Tablet
10 Tablet(s) in StripMRP ₹158.55
₹118.91
25% OFF
Made by
LUPIN
Dosage
TABLET
Expiry
Product Summary
| Salt Content | Aceclofenac(100.0 Mg)+Serratiopeptidase(15.0 Mg)+Paracetamol / Acetaminophen(325.0 Mg) |
| Uses | Joints and muscular pain |
| Therapy | Analgesic/antipyretic, anti-inflammatory |
| Side effects | Nausea, vomiting, dizziness, indigestion, stomach pain |
Assurance
available
Regulated
Medical Description
Signoflam Tablet is a widely used medicine for relieving pain, swelling, and inflammation affecting the muscles, joints, and bones. It is commonly prescribed for conditions like arthritis, spondylitis, sports injuries, and post-surgical pain. Addressing the root cause of pain and inflammation helps patients move more comfortably and improves daily functioning.
This tablet contains a potent combination of Aceclofenac, Paracetamol, and Serratiopeptidase. Aceclofenac and Paracetamol work together to block specific natural substances (prostaglandins) that cause pain and inflammation. Serratiopeptidase helps reduce swelling by breaking down proteins responsible for inflammation, supporting faster healing of damaged tissues. Together, these ingredients offer effective relief and promote recovery.
Signoflam Tablet should be taken strictly as prescribed by your doctor. It is usually advised to be taken with food to prevent stomach upset. Take the medicine at the same time each day for the best results. Avoid skipping doses and do not exceed the prescribed amount, as overuse may lead to unwanted side effects.
Like all medicines, Signoflam may cause side effects such as nausea, dizziness, stomach discomfort, or diarrhoea in some individuals. These effects are generally temporary, but consult your doctor if they persist or worsen. Avoid alcohol while taking this medicine, as it may increase the risk of liver or stomach problems. Patients with a history of kidney, liver, or heart conditions should use this medication with caution.
Other medicines containing the same combination of Aceclofenac, Paracetamol, and Serratiopeptidase include Zerodol Sp tablet, Movexx Sp tablet, Aceclotrue Sp tablet, Acemiz S tablet, and Aldigesic Sp tablet. However, Signoflam Tablet remains a trusted choice for effective relief from pain, swelling, and inflammation.
Uses
Contraindications
- If you have an allergy to Paracetamol, Aceclofenac, Serratiopeptidase or any of the ingredients of this medicine.
- If you have a history of allergies, including asthma, skin rashes or runny nose after taking medicines like Ibuprofen and Aspirin.
- If you have ever experienced severe allergic reactions.
- If you have a history of frequent stomach ulcers or bleeding.
- If you are suffering from any heart disease like heart failure and high blood pressure.
- If you have problems with kidney and liver function.
- If you are pregnant (especially after 3rd month of pregnancy).
Side effects
- Nausea
- Vomiting
- Dizziness
- Indigestion
- Stomach pain
- Constipation
- Diarrhoea
- Bloating
- Stomach ulcers
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You have kidney or liver problems.
- You have heart problems like high blood pressure and heart failure.
- If you are an elderly patient taking diuretics or have kidney disorders, then this medicine can increase the risk of kidney failure. Your doctor may ask you to do renal function tests for the same.
- You are suffering from gastrointestinal problems like bleeding, ulcers in the intestine (perforation) or Crohn's disease, or you notice black tarry stools.
- You have asthma, and this medicine can worsen the same.
- You have SLE (autoimmune disorder).
- You are an alcoholic, and the concomitant use of this medicine can damage the liver.
- You have disorders related to blood, like clotting problems and anaemia.
- You have skin rashes & lesions after taking this medicine.
Directions for Use
Storage and disposal
- Store in a cool and dry place protected from moisture.
- Keep it out of reach of children.
Quick Tips
- Signoflam tablet reduces pain and swelling due to bone and soft tissue injury and post-operative swelling, redness and pain. It should not be used for treating any condition other than that specified by your doctor.
- Do not take more than the daily prescribed dose of this medicine, as it may affect the liver or cause allergic reactions.
- You should inform your doctor if you have experienced asthma, rhinitis, swelling of the face/lips/tongue or hives after taking aspirin or other NSAIDs in the past.
- Before taking this medicine, inform your doctor if you are pregnant, planning on getting pregnant or breastfeeding. Also, inform your doctor about all your medications and medical history.
- Nausea, vomiting, diarrhoea and abdominal pain can be side effects of this medicine in some individuals. If side effects bother you, please inform your doctor.
- Do not take any other paracetamol-containing products while taking Signoflam tablet. Tell your doctor if you have a history or have an alcohol addiction.
Dosage
Overdose
Missed a Dose
- If you have missed any dose of medicine, take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose of medicine to compensate for the missed one.
Mode of Action
How Does It Work?
- This combination acts by interfering with the production of a chemical called prostaglandin which is responsible for swelling and pain.
- It also promotes cartilage matrix synthesis, tissue repair and decreases swelling.
Interactions
Interactions with other medicines
- Do not take any other medicines containing Paracetamol or Aceclofenac, as there is a risk of liver damage.
- If you are taking medicines for high blood pressure, this medicine can interfere with their effect.
- Medicines like water pills can lead to kidney damage when taken along with it.
- Caution is needed if you are taking medicines to treat heart failure.
- This medicine can increase the levels of lithium and methotrexate.
- Medicines used to modify immune responses during organ transplants, like ciclosporin & tacrolimus, can result in kidney damage if taken with this medicine.
- Increased risk of stomach ulcers or bleeding when taken with steroids or other pain relief medicines like Aspirin.
- There is a risk of bleeding if you are taking blood-thinning medicines like Warfarin and Coumarin.
- Increased risk of fits if you are taking this medicine with antibiotics like Levofloxacin and Ciprofloxacin.
- If you are taking medicines to treat diabetes, be cautious about symptoms of low glucose levels like sweating, anxiety, fast heartbeat and hunger pang.
- Medicines used to treat fits, seizures & depression include Phenobarbital, Carbamazepine, Phenytoin and Clonazepam.
- Medicine used to treat gout like Probenecid.
- Medicines used to treat bacterial infections like Chloramphenicol and rifampicin and HIV infections like Zidovudine.
Interactions with food items
Frequently Asked Questions (FAQs)
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Manufacturer Details
Brand:SIGNOFLAM
Manufacturer Name:LUPIN
Address:Concept Pharmaceuticals Ltd-Khasra No 104, Asaf Nagr ,Roorkee -247667 (U.K)
Country of Origin:India
Vendor Details
Fulfillment Information: Signoflam Strip Of 10 Tablets will be delivered by a licensed retail pharmacy nearest to your location. Order acceptance and fulfillment are dependent upon the verification of your doctor's valid prescription (where applicable) and the current stock of this medicine.
References:
- VOLTANEC SP-CiplaMed. 2025 [cited 12th Nov 2025]
- CDSCO [Internet]. Cdscoonline.gov.in. 2025 [cited 12th Nov 2025]
- Aceclofenac+Paracetamol+Serratiopeptidase- NCBI [Internet]. Ncbi.nlm.nih.gov. 2025 [cited 12th Nov 2025]
- National Center for Biotechnology Information (NCBI). Aceclofenac [Internet]. PubChem Compound Database; 2025 [cited 12th Nov 2025]
- DrugBank. Aceclofenac. DrugBank; 2025 [cited 12th Nov 2025]
- Drugs.com. Paracetamol [Internet]. 2025 [cited 12th Nov 2025]
- ScienceDirect. Paracetamol [Internet]. 2025 [cited 12th Nov 2025]
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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.





















