Entacom 200mg Strip Of 10 Tablets
Description
Entacom tablet is a medicine used in adults with Parkinson’s disease as an add-on to standard levodopa therapy. It helps manage “end-of-dose” motor fluctuations, which are periods during which symptoms such as stiffness, slowness, or tremors recur before the next scheduled levodopa dose. By improving the consistency of levodopa’s effect, Entacom tablet helps patients maintain better control over their movements and daily activities.
The medication works by blocking the enzyme catechol-O-methyltransferase (COMT). This enzyme normally breaks down levodopa in the body. By inhibiting COMT, Entacom tablet increases the amount and duration of levodopa in the bloodstream, which helps reduce the “off” periods when Parkinson’s symptoms reappear and improves the overall effectiveness of levodopa therapy.
Entacom tablet is usually administered with each levodopa dose, and it is important to follow the physician’s instructions regarding timing and dosage. It should be swallowed whole with water and can be taken with or after food to reduce stomach upset. Consistent dosing helps maintain stable levodopa levels, reducing symptom fluctuations and improving patients' sense of control over their movements throughout the day.
Some patients may experience side effects such as nausea, diarrhea, abdominal pain, dry mouth, or constipation. Dizziness, sleepiness, or sudden sleep episodes can also occur, particularly when standing up quickly. Patients should be cautious about driving or operating machines until they know how the medicine affects them. Any unusual muscle pain, weakness, or dark urine should be reported to a doctor immediately.
Entacom tablet interacts with certain other medications, including some antidepressants, iron supplements, and catechol-based medicines. It may slightly affect warfarin, a blood-thinning medicine, so monitoring is recommended. Maintaining hydration, a balanced diet, and avoiding abrupt changes in dose can help improve tolerance and effectiveness. Overall, Entacom tablet provides a valuable addition to levodopa therapy, helping patients with Parkinson’s disease manage their symptoms more reliably.
Product Summary
| Offer Price | ₹68.32 |
| You Save | ₹18.16 (21% on MRP) |
| Contains | Entacapone(200.0 Mg) |
| Uses | Parkinson’s disease |
| Side effects | Diarrhoea, abdominal pain, dry mouth, constipation, vomiting |
| Therapy | ANTI-PARKINSONIAN |
Uses
Contraindications
- If you are allergic to entacapone or any of the other ingredients of Entacom tablet.
- If you have liver problems or severe hepatic impairment.
- If you have a tumor called pheochromocytoma.
- If you are taking non-selective MAO inhibitors (e.g., phenelzine, tranylcypromine) at the same time as Entacom tablet.
- If you are taking a combination of selective MAO-A and MAO-B inhibitors with Entacom tablet.
- If you have a history of neuroleptic malignant syndrome (NMS) or unexplained muscle breakdown (rhabdomyolysis).
Side effects
- Nausea
- Diarrhoea
- Abdominal pain
- Dry mouth
- Constipation
- Vomiting
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You have a history of muscle breakdown (rhabdomyolysis) or neuroleptic malignant syndrome (NMS).
- You have heart problems, including ischemic heart disease or low blood pressure when standing (orthostatic hypotension).
- You are taking medicines that affect catecholamines (e.g., adrenaline, dopamine, dobutamine, alpha-methyldopa, apomorphine).
- You are on levodopa or other Parkinson’s medicines, as dose adjustments may be needed to reduce side effects.
- You experience severe or persistent diarrhea, as this may indicate colitis or lead to excessive weight loss.
- You develop impulse control problems, such as compulsive gambling, increased sexual drive, binge eating, or compulsive shopping.
- You experience rapid weight loss, loss of appetite, or general weakness, liver function and overall health should be assessed.
- You have a rare sugar-metabolism disorder (e.g., fructose intolerance, glucose-galactose malabsorption, sucrase-isomaltase deficiency), as this medicine contains sucrose.
- You feel very sleepy or suddenly fall asleep during the day, you should avoid driving or operating machinery.
Directions for Use
- Entacom tablet should be taken as directed by your doctor.
- Swallow it whole with a glass of water.
- It should be taken with or after a meal to reduce its side effects.
- It is best to take it at a fixed time for optimal results, and you should not consume it more than prescribed by your doctor.
Storage and disposal
- Store Entacom tablet in a cool, dry place, protected from direct sunlight, moisture, and heat.
- Keep it out of the reach of children and pets.
Quick Tips
- Monitor for dizziness, sudden sleep episodes, or low blood pressure, especially when standing.
- Avoid driving or operating machinery if you feel drowsy, dizzy, or experience sudden sleep onset.
- Inform your doctor about all other medications you are taking to avoid interactions.
- Report any unusual muscle pain, weakness, dark urine, or signs of infection promptly.
- Keep hydrated and maintain a balanced diet to support overall health.
- Store in a cool, dry place away from direct sunlight and out of reach of children.
- Do not stop or change the dose on your own; consult your doctor before making changes.
Dosage
Overdose
Missed a Dose
Mode of Action
How Does It Work?
Interactions
Interactions with other medicines
- No interactions have been observed between Entacom tablet and carbidopa at the recommended doses. Interaction with benserazide has not been studied.
- No significant interactions were seen in studies with imipramine, moclobemide, or selegiline, though caution is advised when combining Entacom tablet with MAO-A inhibitors, tricyclic antidepressants, noradrenaline reuptake inhibitors (e.g., desipramine, maprotiline, venlafaxine), or catechol-based medicines (e.g., rimiterol, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine, alpha-methyldopa, apomorphine, paroxetine)....
- Entacom tablet can be used with selegiline (a selective MAO-B inhibitor) if the daily dose of selegiline does not exceed 10 mg.
- Entacom tablet may bind to iron in the gut; take iron supplements at least 2–3 hours apart from this medicine.
- Entacom tablet may bind to the same protein sites as medicines like diazepam or ibuprofen, but no significant interactions are expected at normal doses.
- Entacom tablet may slightly affect medicines metabolized by CYP2C9, such as warfarin; blood clotting tests (INR) should be monitored when starting Entacom tablet.
Interactions with food items
- Avoid taking Entacom tablet concurrently with iron supplements, as it can reduce absorption; leave at least 2–3 hours between them.
- There are no significant interactions with other foods, but maintaining a balanced diet supports overall treatment effectiveness.
- Drink adequate water while taking Entacom tablet to help absorption and reduce digestive discomfort.
- Grapefruit or grapefruit juice is not expected to significantly affect Entacom tablet, but it’s generally better to avoid large amounts of grapefruit with any Parkinson’s medications.
Content Details
Ravindra Ghongade
B. Pharm
Dr. Nikita Toshi
BDS (Bachelor of Dental Surgery), WHO FIDES member
Frequently Asked Questions (FAQs)
Q: What is Entacom tablet used for?
Q: What are the common side effects of Entacom tablet?
References
- Central Drugs Standard Control Organization (CDSCO). Drugs: Approved Drugs / Vaccines / r‑DNA / Blood Products [Internet]. Government of India; [cited 2026 Jan 7].
- Mylan Pharmaceuticals Ltd. Entacapone 200 mg tablets: Summary of Product Characteristics [Internet]. UK: Datapharm Ltd.; last updated 11 Mar 2025 [cited 2026 Jan 07].
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