Dolo 650 Tablet
Description
Dolo 650 is one of the over-the-counter (OTC) pain killers and fever reducers. Each tablet contains 650 mg of Paracetamol (Acetaminophen) as its main or active ingredient. Dolo 650 is used to treat toothache, arthritis, headaches, migraines, sore throats, menstrual (period) pain, muscle aches, common cold, and more.
Dolo 650 acts by blocking chemical messengers that are responsible for pain and fever. Usually, it is safe, but for a few individuals, it may cause some side effects. So before taking this medicine, make sure you inform your doctor if you have any liver or kidney diseases or are allergic to any of its ingredients. Also, it is advised not to take more than 4 tablets within 24 hours.
Product Summary
Offer Price | ₹26.39 |
You Save | ₹7.88 (23% on MRP) |
Contains | Paracetamol / Acetaminophen(650.0 Mg) |
Uses | Pain and fever |
Side effects | Nausea, vomiting, headache, skin rashes, constipation, itching, insomnia (difficulty in sleeping), and blisters |
Therapy | ANALGESIC/ANTIPYRETIC |
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Uses
- Dolo 650 is primarily used as an effective fever reducer for adults and children above 12 years.
- It also provides quick relief from migraines and headaches (stress-related and tension).
- In a few cases, Dolo 650 is used to treat body aches, fever, and general discomfort caused by cold and flu.
- Some doctors prescribe it to treat toothaches, minor joint discomfort, mild to moderate back pain, and soreness after immunisations.
- Dolo 650 also helps in managing period-related cramps and discomfort.
Contraindications
- It is advised not to use Dolo 650 if you have an allergy or hypersensitivity to paracetamol or any component of the tablet.
- If you are suffering from severe kidney disease, severe liver disease, liver failure, elevated liver enzymes, chronic or severe malnutrition, or dehydration.
Side effects
- Nausea or stomach discomfort
- Loss of appetite
- Mild skin rash
- Dizziness (rare)
- Severe allergic reactions - Difficulty breathing, swelling of the face or throat
- Unusual bleeding or bruising
- Persistent nausea or vomiting
- Dark urine or pale stools
- Severe stomach pain
- Yellowing of skin or eyes (jaundice)
- Stevens-Johnson syndrome
- Acute generalised exanthematous pustulosis
- Toxic epidermal necrolysis
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- have a history of liver disease, kidney disease, or heart disease.
- have high blood pressure.
- are taking any other medications or products that contain paracetamol.
- are consuming too much alcohol or consuming alcohol regularly.
- are suffering from chronic malnutrition.
Directions for Use
- For adults and children above 12 years, the recommended dosage of Dolo 650 mg is one tablet every 4 to 6 hours as required for relief from fever or pain.
- The maximum limit is 4 tablets in 24 hours, and it is essential to maintain a minimum gap of 4 hours between doses.
- Dolo 650 mg tablet should be taken with a full glass of water.
- You can take it with or without food, but taking it after meals may help prevent stomach discomfort.
- Always swallow the tablet whole; do not crush, chew, or break it.
- Avoid overuse of the recommended dose, as an overdose can cause liver damage.
- Stop taking Dolo 650 mg once your fever or pain reduces, as unnecessary use may harm the liver.
- If symptoms persist for more than 3 days, consult a doctor instead of self-medicating.
- Always keep track of other medicines you are taking, since many cold and flu tablets already contain paracetamol. Combining them with Dolo 650 mg can cause an overdose.
- For safe and effective use, always take Dolo 650 mg only in the recommended dose and duration as prescribed by your doctor.
Storage and disposal
- Dolo 650 tablets should be stored at room temperature, not exceeding 25 °C (77°F).
- Keep in original packaging away from light and moisture.
- Store in a dry place away from the bathroom and kitchen.
- Keep it out of the reach of children and pets.
- Do not flush unused Dolo 650 mg tablets into toilets or sinks.
- Remove or black out all personal information from packaging and dispose of it.
Quick Tips
- Wait at least 4 to 6 hours between doses. To stay safe, do not take more than four tablets in a 24-hour period without consulting your doctor first.
- For fever, do not use for more than 3 days. For pain, limit use to 5 days. If your symptoms don't improve, you must see a healthcare provider.
- Dolo 650 mg tablet is not recommended for children under 12 years of age. Always consult a doctor for pain or fever relief in younger children.
- While generally considered safe, you must consult your doctor before using Dolo 650 during pregnancy or while breastfeeding to ensure the safety of you and your baby.
- Inform your doctor about all medications you take, especially blood thinners or other pain relievers. Taking Dolo 650 mg tablets with antibiotics is generally safe, but it's always best to consult a doctor for confirmation....
- Avoid long-term use of the Dolo 650 mg tablet unless prescribed. It can lead to serious side effects like stomach bleeding or kidney problems. Regular medical check-ups are necessary for extended use.
Dosage
Overdose
Missed a Dose
Mode of Action
How Does It Work?
- Dolo 650 mg tablet works through a dual mechanism. For pain, it works by blocking the brain's pain signals and reducing the production of chemicals (prostaglandins) that cause pain and inflammation.
- To lower a fever, it acts on the hypothalamus, the part of your brain that functions as the body's thermostat. This helps reset your internal temperature to a normal level, efficiently bringing down the fever by promoting heat loss through sweating....
- After taking a Dolo 650 tablet, you can expect to feel relief relatively quickly, as it begins to work within 30 to 60 minutes. The tablet reaches its maximum effectiveness, providing peak relief from pain and fever, between one and three hours after consumption....
- The effects of a single dose are designed to last for a duration of four to six hours, helping you stay comfortable before another dose may be necessary.
Interactions
Interactions with other medicines
- Avoid taking Dolo 650 with other medicines containing Paracetamol, as many cold, flu, and pain relief products already have it. Combining them can cause accidental overdose and serious liver damage. Always read the labels on other medications....
- Blood Thinners (e.g., Warfarin): Using Dolo 650 long-term and daily can increase bleeding risk. Occasional use is usually safe, but seek medical advice.
- Seizure Medications (Anti-epileptics): May change how the body processes Paracetamol, affecting safety and effectiveness.
- Nausea Medications (e.g., Metoclopramide, Domperidone): Can cause Dolo 650 to be absorbed faster, making it work quicker.
- Cholesterol Medication (e.g., Colestyramine): Can slow down the absorption of Dolo 650, reducing its effectiveness. Your doctor may suggest spacing out the doses.
Interactions with food items
Content Details

Dr. Nikita Toshi
BDS (Bachelor of Dental Surgery), WHO FIDES member

Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: What is Dolo 650 used for?
Q: What is the correct dosage of Dolo 650 for adults?
Q: Is it safe to take Dolo 650 during pregnancy or while breastfeeding?
Q: Can I take Dolo 650 with other medicines?
Q: What are the common side effects of Dolo 650?
Q: Is it safe to consume alcohol with Dolo 650?
Q: How quickly does Dolo 650 work, and how long do the effects last?
Q: What should I do if I miss a dose of Dolo 650?
Q: Can Dolo 650 be given to children?
Q: What is the difference between Dolo 650 and other paracetamol tablets?
References
- U.S. Food and Drug Administration. Acetaminophen [Internet]. Silver Spring (MD): U.S. Food and Drug Administration; 2025 Aug 14 [cited 2025 Sep 4].
- Orandi BJ, McLeod MC, MacLennan PA, Lee WM, Fontana RJ, Karvellas CJ, McGuire BM, Lewis CE, Terrault NM, Locke JE; US Acute Liver Failure Study Group. Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure. JAMA. 2023 Mar 7;329(9):735–744. doi:10.1001/jama.2023.1080. [cited 2025 Sep 4].
- World Health Organization. WHO Model List of Essential Medicines – 23rd list, 2023 [Internet]. Geneva: World Health Organization; 2023 Jul 26 [cited 2025 Sep 4].
- Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013 Jun;21(3):201–232. doi: 10.1007/s10787-013-0172-x. [cited 2025 Sep 4].
- U.S. Food and Drug Administration. FDA issues agency-initiated proposed order regarding OTC monograph drugs containing acetaminophen [Internet]. Silver Spring (MD): U.S. Food and Drug Administration; 14 June 2024 [cited 2025 Sep 4].
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