Domperidone
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Molecule Description
Domperidone is an anti-sickness medicine. It is used for the treatment of nausea and vomiting. It increases the movement of food into the stomach, thereby helps in indigestion. It is also used to treat gastroesophageal reflux disease and gastroparesis (sluggish movements of the stomach). It belongs to the anti-emetic (emesis - vomiting) group of medicines. Domperidone is available in the form of a tablet, capsule, syrup, suspension, oral drops, rectal suppository. Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding and about all the medicines and supplements you take and all the conditions or diseases you suffer from, before starting domperidone.
Uses
- Domperidone is used to relieve nausea and vomiting.
- It increases the movement of food into the stomach, thus helps in indigestion.
- It is also used to treat gastroesophageal reflux disease and gastroparesis (sluggish movements of the stomach).
Contraindications
When should one not use Domperidone
- If you are allergic to domperidone or similar medicines
- If you have problems with your heart, liver or kidney
- If you have a blockage or tear in the intestines
- If you have a low level of potassium or magnesium or a high level of potassium in your blood
- If you have a tumour of the pituitary gland called a prolactinoma
- If you have black, tarry bowel stools or blood in stools
Side effects
Common side effects of this drug are:
- Dry mouth
- Drowsiness
- Headache
- Fatigue
- Sleepiness
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have problems with your liver or kidneys
- You are allergic to or develop any allergic reactions after taking the medicine.
- You experience palpitations, breathing problems or unconsciousness after domperidone.
Mode of Action
How Does It Work?
Domperidone blocks the action of a chemical substance (dopamine) in the brain, which causes nausea and vomiting. It also increases the movement of the stomach and intestines to allow easy movement of food through the stomach.
Interactions
Interactions with other medicines
- Some medicines can affect the way domperidone works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
- Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
- Especially if you are taking medicines to treat heart problems, psychiatric illnesses, problems related to stomach and intestines, cancer, malaria, HIV infection, allergy, fungal or bacterial infections.
Frequently Asked Questions (FAQs)
Articles
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References:
- CDSCO - Domperidone [Internet]. Cdscoonline.gov.in. 2025 [cited 25 Oct 2025]
- Motilium tablets (Domperidone) [Internet]. Janssen.com. 2025 [cited 27 Oct 2025]
- Domperidone 10mg Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 27 Oct 2025]
- Domperidone 10mg Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 27 Oct 2025]
- Medex.com.bd. Domperidone Maleate Suppository — Prescribing Information [Internet]. Dhaka: Medex; 2025 [cited 27 Oct 2025]
- Domperidone 1mg/ml Oral Suspension - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 27 Oct 2025]
- Domperidone 1mg/ml Oral Suspension - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 27 Oct 2025]
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