Molecule Description

Domperidone is an anti-sickness medicine. It is used for the treatment of nausea...
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Uses of Domperidone

  • Domperidone is used to relieve nausea and vomiting.
  • It increases the movement of food into the stomach, thus helps in indigestion.
  • It is also used to treat gastroesophageal reflux disease and gastroparesis (sluggish movements of the stomach).

Contraindications of Domperidone

When should one not use Domperidone

  • If you are allergic to domperidone or similar medicines
  • If you have problems with your heart, liver or kidney
  • If you have a blockage or tear in the intestines
  • If you have a low level of potassium or magnesium or a high level of potassium in your blood
  • If you have a tumour of the pituitary gland called a prolactinoma
  • If you have black, tarry bowel stools or blood in stools

Side effects of Domperidone

Common side effects of this drug are:

  • Dry mouth
  • Drowsiness
  • Headache
  • Fatigue
  • Sleepiness

Precautions and Warnings of Domperidone



Can I use domperidone during pregnancy?
It is not advised to take domperidone during pregnancy until it is considered essential by the doctor and potential risks justify the benefits.

Breast Feeding

Can I use domperidone while breastfeeding?
Domperidone passes into breast milk in small amounts. Thus, your doctor will decide on either discontinuing the medicine or breastfeeding after assessing the potential risk on breastfeeding infant over the risk of delayed treatment on breastfeeding mother.


Can I drive if I have used domperidone?
Domperidone may cause sleepiness, confusion, less control over your movements, thus you need to be cautious while driving.


Can I consume alcohol with domperidone?
Avoid consuming alcohol with domperidone, as it may worsen the side effects.

Other General Warnings

Talk to your doctor if
  • You have problems with your liver or kidneys
  • You are allergic to or develop any allergic reactions after taking the medicine.
  • You experience palpitations, breathing problems or unconsciousness after domperidone.

Mode of Action of Domperidone

How Does It Work?

Domperidone blocks the action of a chemical substance (dopamine) in the brain, which causes nausea and vomiting. It also increases the movement of the stomach and intestines to allow easy movement of ...
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Interactions of Domperidone

Interactions with other medicines

  • Some medicines can affect the way domperidone works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
  • Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
  • Especially if you are taking medicines to treat heart problems, psychiatric illnesses, problems related to stomach and intestines, cancer, malaria, HIV infection, allergy, fungal or bacterial infectio...
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Content Details


Dr. Mansi Savla

B. Pharm, PharmD


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: In which all dosage forms is domperidone available?

A: Domperidone is available in the form of a tablet, capsule, syrup, suspension, oral drops, rectal suppository.

Q: How does domperidone work?

A: Domperidone works by blocking the action of dopamine (a chemical substance) in the brain, which causes nausea and vomiting. It also increases the movement of the stomach and intestines to allow easy movement of food through the stomach.
Last Updated on: 01 Nov 2021 | 01:36 PM (IST)
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