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Domperidone

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Molecule Description

Domperidone is an anti-sickness medicine. It is used for the treatment of nausea and vomiting. It increases the movement of food into the stomach, thereby helps in indigestion. It is also used to treat gastroesophageal reflux disease and gastroparesis (sluggish movements of the stomach). It belongs to the anti-emetic (emesis - vomiting) group of medicines. Domperidone is available in the form of a tablet, capsule, syrup, suspension, oral drops, rectal suppository. Inform your doctor if you are pregnant, planning a pregnancy or breastfeeding and about all the medicines and supplements you take and all the conditions or diseases you suffer from, before starting domperidone.

Uses

  • Domperidone is used to relieve nausea and vomiting.
  • It increases the movement of food into the stomach, thus helps in indigestion.
  • It is also used to treat gastroesophageal reflux disease and gastroparesis (sluggish movements of the stomach).

Contraindications

When should one not use Domperidone

  • If you are allergic to domperidone or similar medicines
  • If you have problems with your heart, liver or kidney
  • If you have a blockage or tear in the intestines
  • If you have a low level of potassium or magnesium or a high level of potassium in your blood
  • If you have a tumour of the pituitary gland called a prolactinoma
  • If you have black, tarry bowel stools or blood in stools

Side effects

Common side effects of this drug are:

  • Dry mouth
  • Drowsiness
  • Headache
  • Fatigue
  • Sleepiness

Precautions and Warnings

Pregnancy

Pregnancy

It is not advised to take domperidone during pregnancy until it is considered essential by the doctor and potential risks justify the benefits.

Breast Feeding

Breast Feeding

Domperidone passes into breast milk in small amounts. Thus, your doctor will decide on either discontinuing the medicine or breastfeeding after assessing the potential risk on breastfeeding infant over the risk of delayed treatment on breastfeeding mother.

Driving

Driving

Domperidone may cause sleepiness, confusion, less control over your movements, thus you need to be cautious while driving.

Alcohol

Alcohol

Avoid consuming alcohol with domperidone, as it may worsen the side effects.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have problems with your liver or kidneys
  • You are allergic to or develop any allergic reactions after taking the medicine.
  • You experience palpitations, breathing problems or unconsciousness after domperidone.

Mode of Action

How Does It Work?

Domperidone blocks the action of a chemical substance (dopamine) in the brain, which causes nausea and vomiting. It also increases the movement of the stomach and intestines to allow easy movement of food through the stomach.

Interactions

Interactions with other medicines

  • Some medicines can affect the way domperidone works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
  • Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
  • Especially if you are taking medicines to treat heart problems, psychiatric illnesses, problems related to stomach and intestines, cancer, malaria, HIV infection, allergy, fungal or bacterial infections.

Frequently Asked Questions (FAQs)

Domperidone is available in the form of a tablet, capsule, syrup, suspension, oral drops, rectal suppository.

Domperidone works by blocking the action of dopamine (a chemical substance) in the brain, which causes nausea and vomiting. It also increases the movement of the stomach and intestines to allow easy movement of food through the stomach.

Common side effects include dry mouth, headache, mild stomach cramps, or dizziness. These are usually short-lived. If you experience irregular heartbeat, chest pain, or fainting, stop taking the medicine and seek medical help immediately.

It’s best to take Domperidone before meals, as it helps the medicine work more effectively in controlling nausea and improving digestion. Taking it after food may reduce its effectiveness.

It’s best to avoid alcohol while taking Domperidone, as alcohol can increase drowsiness and may irritate your stomach, worsening symptoms like nausea or acid reflux.

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