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Depranil Plus Tablets

10 Tablet(s) in Strip
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Depranil Plus Tablets Description

Depranil Plus Tablet is a prescription medication. It is used in the treatment of all kinds of depression, such as depression due to illness, severe potentially suicidal depression, and neurotic and

reactive depression. This mental disorder causes persistent feelings of sadness, irritability, and loss of interest in life. It may be associated with other types of mood disorder or phobic states like the fear of flying, heights, agoraphobia (fear of open places and crowds), etc. The active ingredients in Depranil Plus tablets are Imipramine and Diazepam. The mode of action of Depranil Plus tablets is by increasing the levels of a specific chemical messenger in the brain, responsible for balancing mood swings and providing a calming effect. Directions for use of Depranil Plus Tablet should be strictly followed. Do not suddenly stop this medicine as this can cause withdrawal symptoms like sweating, shaking, irritation, etc. Depranil Plus tablet use should be monitored for suicidal tendencies.


Product Summary

Offer Price₹14.28
You Save₹2.32 (14% on MRP)
ContainsImipramine(25.0 Mg) + Diazepam(5.0 Mg)
UsesAll types of depression
Side effectsSleepiness, Dry mouth, Nausea, Vomiting, Diarrhoea, Constipation, Nervousness, Decreased sexual drive or ability, Decreased concentration and memory
Check more medicines with composition as Imipramine(25.0 Mg) + Diazepam(5.0 Mg)

Uses of Depranil Plus Tablets

  • As per CDSCO, Depranil Plus tablets are used to manage all kinds of depression symptoms.

Contraindications of Depranil Plus Tablets

Do not take Depranil Plus tablets or use caution: If you have an allergic reaction to Imipramine or Diazepam If you are using other antidepressant medications If you notice sudden mood changes, ...
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Side effects of Depranil Plus Tablets

  • Side effects of Depranil Plus tablets include:
  • Sleepiness
  • Dry mouth
  • Nausea
  • Vomiting
  • Diarrhoea
  • Decreased sexual drive or ability
  • Decreased concentration and memory

Precautions and Warnings of Depranil Plus Tablets



Can I take Depranil Plus tablets during pregnancy?
No. Depranil Plus tablets may not be safe during pregnancy. There is not enough data on the side effects of this medicine on pregnant women and foetuses. Consult your doctor before using Depranil Plus tablets if you are pregnant or planning to conceive.

Breast Feeding

Can I take Depranil Plus tablets while breastfeeding?
No. Depranil Plus tablets are not advised for nursing mothers. Some data suggests this medicine may seep into breast milk and cause withdrawal symptoms in breastfed infants.


Can I drive if I have taken a Depranil Plus tablet?
No. Depranil Plus tablets can cause adverse effects like drowsiness, slow reflexes, dizziness, difficulty concentrating, etc., affecting your ability to drive or operate heavy machinery.


Can I consume alcohol with Depranil Plus tablets?
Depranil Plus tablets with alcohol can cause increased side effects like extreme drowsiness, lethargy, vomiting, agitation, blurry vision, double vision, muscle stiffness, sweating, etc.

Other General Warnings

Talk to your doctor if
  • You have suicidal thoughts after taking Depranil Plus tablets.
  • You use tobacco products. Cigarette smoking may reduce the effectiveness of this medicine.
  • You are an older adult over 65. The dose of Depranil Plus tablets needs to be carefully monitored to prevent excessive side effects.
  • You have a history of diabetes, irregular heartbeat, blood pressure issues, thyroid problems, etc.
  • You use Ayurvedic or herbal medicines (St John's wort). Interaction with these can cause Serotonin Syndrome with life-threatening side effects like agitation, delirium, and coma.

Mode of Action of Depranil Plus Tablets

How Does It Work?

The Depranil Plus tablet contains Imipramine and Diazepam as its active substance. Imipramine is a tricyclic antidepressant medication. It is believed that it works by stopping the reuptake of che...
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Directions for Use of Depranil Plus Tablets

  • Take the tablet in the exact dose and at the same time every day as prescribed by the doctor.
  • Do not exceed the dosage of Depranil Plus tablets, even if you cannot notice its effects.
  • Take this tablet as a whole with a glass of water, without breaking, chewing or crushing it.
  • Do not use Depranil Plus tablets with other medications without informing your doctor.
  • Do not abruptly stop this medication; this can result in withdrawal effects.

Interactions of Depranil Plus Tablets

Interactions with other medicines

  • Do not use Depranil Plus tablets along with monoamine oxidase inhibitors (MAOIs) like linezolid, methylene blue, phenelzine, selegiline, etc. This can result in side effects like tremors, severe seizu...
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  • Do not take medicine with a similar composition as Depranil Plus tablets. Compounds like sertraline, fluoxetine, paroxetine, etc. can exaggerate the side effects of Depranil Plus tablets.
  • Do not use this tablet with other medicines that cause sedation and drowsiness, like tranquillisers, narcotic pain relievers, muscle relaxants, etc.
  • Some other medicines that can react with Depranil Plus tablets are:
  • Blood thinners (warfarin)
  • Heart medication (digoxin)
  • anticholinergic medicines (including anti-Parkinsonism agents like levodopa)
  • Anti-seizure medications (phenytoin, phenobarbital)
  • High blood pressure medicines

Interactions with food items

  • Avoid grapefruit and cranberry (and their juice). These fruits can increase the levels of this medicine in your blood and cause unwanted adverse effects.

Storage and disposal of Depranil Plus Tablets

Store Depranil Plus tablets in dry conditions at room temperature, away from wet surfaces, direct sunlight, and humidity. Keep away from children and pets. Check the expiration date before taking the ...
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Dosage of Depranil Plus Tablets


Depranil Plus tablet overdose can lead to symptoms like extreme drowsiness, nausea, irregular or fast heartbeat, dizziness, fainting, seizures, decreased urination, unusual movements, slow breathing, ...
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Missed a Dose

If you have missed a dose of Depranil Plus tablet, try to take it as soon as you remember. If you recall the missed dose when it is almost time for the next one, skip the missed one and continue with ...
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Content Details


Dr. Vijay Y

MBBS, MD in Clinical Pharmacology

Frequently Asked Questions (FAQs)


Q: Can I take a Depranil Plus tablet if I have diabetes?

A: Persons with diabetes should be monitored for worsening blood sugar levels when under treatment with Depranil Plus tablets, especially if the dosage has been altered. Studies have shown varying results. Some show raised blood sugar levels, while some show the opposite. Regular monitoring of your blood sugar levels is essential.

Q: Will I gain weight while using Depranil Plus tablets?

A: A study indicates weight gain from long-term use of Depranil Plus tablets. However, the results are not conclusive. Try to stay active and eat healthy food to maintain a stable weight.

Q: Is the Depranil Plus tablet a habit-forming medicine?

A: The Diazepam part of Depranil Plus tablets is a highly addictive and commonly abused medication. It also has habit-forming potential. The dose of this medication should be carefully monitored. It can also cause adverse withdrawal effects when stopped suddenly. The dose should be slowly tapered. Consult your doctor.
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Last Updated on: 14 Mar 2022 | 10:03 AM (IST)

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The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here  for detailed T&C.
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