Cosvate GM Cream
Description
Cosvate-GM Cream is a prescription medication used to treat a variety of inflammatory and infectious skin conditions, including eczema, dermatitis, psoriasis, and certain autoimmune-related skin diseases. It is a triple-combination cream containing clobetasol propionate (a potent corticosteroid that reduces redness, swelling, and itching), miconazole nitrate (an antifungal that combats fungal infections), and gentamicin (an antibiotic that prevents or treats bacterial infections).
This cream is not suitable for conditions such as acne, rosacea, perioral dermatitis, itching around the anus or genitals, infected or itchy skin without a doctor’s advice, or widespread plaque psoriasis. Incorrect use of Cosvate-GM may worsen the condition or cause unnecessary side effects.
Before applying Cosvate-GM, inform your doctor if you have a history of bone-related issues, allergies to steroids, broken or damaged skin, chronic leg ulcers, or psoriasis. This helps determine whether the cream is safe for you. Extra caution should be exercised when using the cream on sensitive areas like the face, underarms, or groin.
Cosvate-GM cream should be applied exactly as prescribed, usually in a thin layer over the affected area. Do not extend the duration of use beyond what is advised, and avoid covering the treated skin with tight bandages unless instructed by your doctor. Overuse of corticosteroid creams can lead to skin thinning or other long-term side effects.
Common side effects of Cosvate-GM include burning, irritation, redness, itching, or discomfort at the application site. These effects are typically mild and temporary, but if they persist or worsen, consult your doctor immediately. Use this cream with caution during pregnancy or breastfeeding, and only under strict medical supervision.
Product Summary
Offer Price | ₹32.97 |
You Save | ₹9.85 (23% on MRP) |
Contains | Clobetasol(0.05 %)+Miconazole(2.0 %)+Gentamicin(0.1 %) |
Uses | Skin infections |
Side effects | Burning, irritation, itching, allergy, thinning of skin |
Therapy | TOPICAL ANTIMICROBIAL AND STEROID |
Uses
Contraindications
- If you are allergic to clobetasol, gentamicin, miconazole, or any of the ingredients in Cosvate-GM cream.
- It should not be used for treating infection in your private parts, face, acne, around mouth and skin perforations.
- If you have any untreated skin infections or skin thinning problems.
- You should not use this cream if you have chickenpox, shingles, warts or any other wounds and skin infections.
- This medicine should not be used in children below 1 year of age and for nappy rash.
Side effects
- Burning
- Irritation
- Itching
- Allergy
- Thinning of skin
- Cracks on skin
- Redness
- Dryness
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You experience any allergic reactions to the skin after applying Cosvate-GM cream.
- You experience other infections after applying this cream.
- It would be best if you do not use this cream on any condition other than prescribed by your doctor.
- In case you experience any skin reactions after applying this cream, inform your doctor immediately.
- You should not apply this cream for a prolonged duration on a larger skin area or more than the prescribed duration.
- In case your eyes come in contact with this medicine, rinse your eyes with clean water immediately.
Directions for Use
- Use Cosvate-GM cream as directed by your doctor and follow all the instructions.
- For external use only, apply it on healthy skin surfaces free from cuts and wounds.
- Wash your hands before and after using Cosvate GM cream unless your hands are the area to be treated.
- Apply a thin layer and rub gently to cover the affected area for days and times advised by your doctor.
- If you do not see any improvement in your condition within 15 days, you should consult your doctor.
Storage and disposal
- Store Cosvate-GM cream below 25°C, protected from moisture, sun light and heat.
- Keep the medicine away from children and pets.
Quick Tips
- Do not use more than the prescribed amount of Cosvate GM cream, or do not use it for longer periods of time than recommended by your doctor.
- Wash your hands before and after using this medicine. If your eyes come in contact with this cream, then rinse your eyes with clean water immediately.
- Do not give this medicine to anyone else, even if they have the same condition as you do.
- If you experience any allergic reactions after using this medicine, talk to your doctor immediately.
- Do not use this medicine for children below 1 year of age.
Dosage
Overdose
Missed a Dose
Mode of Action
How Does It Work?
- During inflammation or infection of the skin, the body releases some chemical substances which make the skin red, itchy and swollen.
- Clobetasol is a steroid which acts by blocking the synthesis of natural substances, i.e. prostaglandins, which are responsible for itching, swelling and redness.
- Miconazole works by inhibiting the formation of a fungal cell wall component, which leads to altered permeability and growth of fungus, causing infection.
- Gentamicin is an antibiotic agent which is widely used for treating various bacterial infections of the skin. It works by inhibiting the growth and multiplication of bacteria causing infection.
- Collectively, all these medicines work more effectively by reducing the infection and inflammation of the skin.
Interactions
Interactions with other medicines
- Cosvate-GM cream is meant for local application on the skin and, thus, is less likely to interact with other medicines taken orally. However, it may interact with other topically applied medicine. Discuss with your doctor if you are already on another topical medicine....
- There is limited information available on the interaction of Cosvate-GM cream with other medicines. However, as Cosvate-GM cream contains three different components, any interaction seen with these three components when taken alone may occur with this combination....
- Be cautious if you are taking antifungal medicines like Itraconazole and Ritonavir, which are used in HIV infection, antibiotics such as erythromycin, and blood-thinning agents like warfarin and Verapamil used in heart problems....
Interactions with food items
Content Details

Dr. Mansi Savla
B. Pharm, PharmD

Dr. Ritu Budania
MBBS, MD (Pharmacology)
Frequently Asked Questions (FAQs)
Q: Cosvate GM vs Betnovate GM, are they the same?
Q: What will happen if I accidentally ingest Cosvate GM cream?
Q: Can Cosvate GM cream be used in children?
Q: Can I use Cosvate-GM cream for pimples?
Q: Is Cosvate-GM cream a steroid?
Q: I am having a history of rashes with the use of other medicine, should I use Cosvate GM cream?
Q: Can I use Cosvate-GM cream longer than the prescribed duration?
Q: How to use Cosvate-GM cream?
Q: What are the side-effects of Cosvate-GM cream?
Q: Is Cosvate GM good for acnes?
Q: Can Cosvate GM be used for diaper rash?
Q: What is the use of Cosvate-GM cream?
Q: Can I stop applying Cosvate-GM cream when my symptoms are relieved?
References
- Dermovate Cream - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [cited 1 April 2022]
- DailyMed - Gentamicin Sulfate cream [Internet]. Dailymed.nlm.nih.gov. 2022 [cited 1 April 2022]
- Dermovate Cream - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2022 [cited 1 April 2022]
- Chaves BJ, Tadi P. Gentamicin. [Updated 2023 Apr 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. [Accessed 27 Dec. 2024].
- Gentamicin [Internet]. ScienceDirect Topics. [Accessed 27 Dec. 2024].
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 4189, Miconazole. Retrieved December 27, 2024
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 5311051, Clobetasol. Retrieved December 27, 2024
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