Combihale G Strip Of 10 Inhalation Capsules
By MANKIND PHARMACEUTICALS LTD
10 Inhalation Capsule(s) in Strip
₹106.14
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₹145.40
27% OFF
₹10.61/inhalation capsule
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Description
Combihale G inhalation capsule is a combination medicine used for long-term maintenance treatment in adults with moderate to severe Chronic obstructive pulmonary disease (COPD). It helps open the airways, making breathing easier, and reduces symptoms such as coughing, wheezing, and shortness of breath. The medication also helps prevent exacerbations of Chronic obstructive pulmonary disease (COPD), particularly when other inhalers are insufficient.
Budesonide is a corticosteroid that reduces airway inflammation, swelling, and mucus, thereby improving airflow and decreasing COPD exacerbations. Glycopyrronium, a long-acting muscarinic antagonist (LAMA), relaxes airway smooth muscle and maintains airway patency, thereby improving breathing and lung function. Formoterol, a long-acting beta2-agonist (LABA), relaxes airway smooth muscle, improves airflow, reduces wheezing and shortness of breath, and facilitates daily activities.
Combihale G inhalation capsule should be used exactly as prescribed, with proper inhaler technique and regular monitoring. It is not intended for the sudden relief of breathlessness, and patients should follow medical advice regarding other medications, pregnancy, and coexisting conditions to ensure safety and effectiveness.
Product Summary
| Offer Price | ₹106.14 |
| You Save | ₹39.26 (27% on MRP) |
| Contains | Glycopyrronium Bromide / Glycopyrrolate(25.0 Mcg)+Formoterol Fumarate(12.0 Mcg)+Budesonide(400.0 Mcg) |
| Uses | Chronic obstructive pulmonary disease (COPD) |
| Side effects | Oral thrush (fungal infection in the mouth), headaches, dizziness, nausea, nasal congestion, and throat irritation. |
| Therapy | DRUGS FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE |
Uses
Combihale G inhalation capsule is indicated for the long-term maintenance treatment of adults diagnosed with moderate to severe Chronic Obstructive Pulmonary Disease (COPD).
Contraindications
If you are allergic to any of the ingredients in Combihale G inhalation capsule.
Side effects
- Oral candidiasis
- Pneumonia
- Anxiety
- Insomnia
- Headache
Precautions and Warnings
Other General Warnings
Talk to your doctor if
- You need relief from sudden breathing problems; this medication is not for acute use.
- You experience immediate wheezing or shortness of breath after using the inhaler, as this may indicate paradoxical bronchospasm.
- Your COPD symptoms suddenly worsen, or you need to use your reliever inhaler more often, as this may indicate disease deterioration.
- You have heart problems, arrhythmias, or severe cardiovascular disease, as this medicine can affect the heart.
- You have a known or suspected prolonged QTc interval, as the medicine may affect heart rhythm.
- You are at risk of systemic corticosteroid effects, such as adrenal suppression, reduced bone density, cataract, or glaucoma.
- You are switching from oral steroids, as your adrenal function may still be impaired, and stress doses may be needed.
- You develop a fever, increased cough, or worsening shortness of breath, as these may be signs of pneumonia.
- You have low potassium or take other medicines that can lower potassium, as this medicine may increase the risk of hypokalaemia.
- You have diabetes, as the medicine may increase blood sugar levels.
- You have thyroid problems, urinary retention, prostatic enlargement, or narrow-angle glaucoma due to anticholinergic effects.
- You are taking other medicines with anticholinergic effects, as combining them may increase side effects.
- You have severe kidney or liver problems, as the medicine may need careful monitoring or dose adjustment.
Pregnancy
Q:
Can I use Combihale G inhalation capsule during pregnancy?
A:
Use of Combihale G inhalation capsule during pregnancy should only be considered if the expected benefit to the mother outweighs any potential risk to the baby. Limited data suggest that budesonide is generally safe; very small amounts of glycopyrronium may cross the placenta; and high doses of formoterol in animals have shown some risk. Always consult your doctor before using Combihale G inhalation capsule while pregnant.
Breast Feeding
Q:
Can I use Combihale G inhalation capsule while breastfeeding?
A:
Use of Combihale G inhalation capsule while breastfeeding should only be considered if the expected benefit to the mother outweighs any possible risk to the baby. Budesonide passes into breast milk in very small amounts, with no expected effects on the infant, while it is not known whether glycopyrronium or formoterol is excreted. Always consult your doctor before using Combihale G inhalation capsule while breastfeeding.
Driving
Q:
Can I drive if I have used Combihale G inhalation capsule?
A:
Combihale G inhalation capsule has little or no effect on your ability to drive or use machines. However, dizziness is an uncommon side effect, so you should be careful and see how you react before driving or operating machinery. Always consult your doctor if you are unsure.
Alcohol
Q:
Can I consume alcohol with Combihale G inhalation capsule?
A:
No known information is available.
Directions for Use
- Use Combihale G inhalation capsule exactly as prescribed by your doctor.
- Rinse your mouth with water after use to reduce the risk of throat irritation or oral infections.
Storage and disposal
- Store in a cool, dry place, away from direct sunlight, heat, and moisture.
- Keep it out of reach of children and pets.
Quick Tips
- Do not use this medicine to relieve sudden breathing problems or asthma attacks.
- Monitor for signs of worsening COPD, such as increased cough, breathlessness, or need for a reliever inhaler.
- Be aware of potential side effects, such as dizziness, a rapid heartbeat, or visual changes, and report them to your physician.
- Avoid using other inhalers containing anticholinergics or corticosteroids without medical advice.
- Attend regular check-ups to monitor heart health, blood glucose, and lung function while taking this medication.
- Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding, to ensure the inhalation capsule is safe for you and your baby.
Dosage
Overdose
If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
Missed a Dose
If you miss any dose of Combihale G inhalation capsule, take it as soon as you remember. However, if it is time for the next dose, then skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up....
Mode of Action
How Does It Work?
- Budesonide: A corticosteroid that reduces inflammation in the airways, helping to decrease swelling and mucus production, which makes breathing easier and helps prevent COPD flare-ups.
- Glycopyrronium: A long-acting muscarinic antagonist (LAMA) that relaxes the airway muscles by blocking certain receptors, helping to keep the airways open for easier breathing.
- Formoterol Fumarate: A long-acting beta2-agonist (LABA) that relaxes the muscles around the airways, improving airflow and reducing symptoms like wheezing and shortness of breath.
Interactions
Interactions with other medicines
- CYP3A4 primarily metabolizes Budesonide; therefore, strong CYP3A4 inhibitors such as itraconazole, ketoconazole, HIV protease inhibitors, and cobicistat-containing products can increase the risk of adverse effects. Short-term use (1–2 weeks) is usually of limited concern....
- High-dose budesonide with itraconazole may increase blood budesonide levels by up to fourfold.
- The kidneys primarily eliminate glycopyrronium; therefore, drugs that affect renal excretion, such as cimetidine, can slightly increase its plasma concentrations.
- Using Combihale G inhalation capsule with other anticholinergic or long-acting β2-agonist medications is not recommended, as it may increase adverse effects.
- Using other beta-adrenergic medicines alongside formoterol may have additive effects, so caution is needed.
- Medicines that lower potassium (like xanthine derivatives, steroids, and certain diuretics) may increase the risk of low potassium and heart rhythm problems.
- Beta-blockers, including eye drops, can reduce the effect of formoterol. Cardio-selective beta-blockers are preferred if needed.
- Medicines like quinidine, disopyramide, procainamide, certain antihistamines, MAO inhibitors, tricyclic antidepressants, and phenothiazines can prolong the QT interval and increase the risk of heart rhythm problems....
- L-DOPA, L-thyroxine, oxytocin, and alcohol can affect how the heart responds to beta2-agonists like formoterol.
- Using monoamine oxidase inhibitors or similar medicines may cause high blood pressure reactions.
- There is an increased risk of heart rhythm issues if anesthesia with halogenated hydrocarbons is used while taking this inhaler.
Interactions with food items
- There are no known major food interactions, but taking it with a meal may help reduce throat irritation.
- Avoid consuming very large amounts of alcohol while using this inhalation capsule, as it may worsen dizziness or lightheadedness.
Content Details
WRITTEN BY
Ravindra Ghongade
B. Pharm
REVIEWED BY
Dr. Nikita Toshi
BDS (Bachelor of Dental Surgery), WHO FIDES member
Frequently Asked Questions (FAQs)
Q: Can Combihale G inhalation capsule be used for sudden breathing problems?
A: No, Combihale G inhalation capsule is not for acute episodes of breathlessness. Use a fast-acting reliever inhaler for sudden symptoms.
Q: Can pregnant or breastfeeding women use Combihale G inhalation capsule?
A: Women who are pregnant, planning pregnancy, or breastfeeding should inform their doctor before using Combihale G inhalation capsule to ensure it is safe.
Q: Can I use other inhalers with Combihale G inhalation capsule?
A: Do not use other inhalers containing anticholinergics or corticosteroids without your doctor’s guidance, as combining them may increase side effects.
References
- Central Drugs Standard Control Organization (CDSCO). Drugs: Approved Drugs / Vaccines / r-DNA / Blood Products [Internet]. Government of India; [cited 2025 Dec 29].
- AstraZeneca UK Limited. Trixeo Aerosphere 5 micrograms/7.2 micrograms/160 micrograms pressurised inhalation, suspension: Summary of Product Characteristics [Internet]. UK: Datapharm Ltd.; last updated 31 Jul 2025 [cited 2025 Dec 29].
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Product Details
Brand
COMBIHALE
Country of Origin
India
Expiry Date
30/03/2027
Manufacturer Details
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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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