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Trimetazidine

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Molecule Summary

Uses
Managing symptoms of angina pectoris (heart related chest pain)
Therapy
Anti-Anginal
Side Effects
Dizziness, headache, stomach ache, diarrhoea, indigestion
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Molecule Description

Trimetazidine is used as an add-on therapy for managing symptoms of angina pectoris, a condition characterised by radiating chest pain due to decreased oxygen and blood supply to the heart. It belongs to the class of medicines acting on the heart. Trimetazidine is a metabolic antianginal agent that prevents a drop in cellular energy and ensures the proper functioning of the heart cells. Trimetazidine does not help reduce angina attacks but only helps relieve its symptoms. This medicine should be taken as directed by the doctor and in doses and duration as prescribed. Some common side effects of Trimetazidine are headache, diarrhoea, stomach pain, weakness and rash. Most of these are temporary, but if you feel the side effects persist, you should contact your doctor immediately. Before using Trimetazidine, inform the doctor if you are pregnant, planning a pregnancy or breastfeeding and about your detailed medical history.

Uses

Trimetazidine is used as an add on therapy for the symptomatic treatment of angina pectoris.

Contraindications

When should one not use Trimetazidine

  • If you are allergic to trimetazidine or any ingredient of this medicine.
  • If you have a brain-related disorder called Parkinson's Disease or symptoms such as tremors, shakiness, and stiffness.
  • If you have restless leg syndrome (excessive urge to move legs) or movement disorders.
  • If you have severe kidney problems or kidney failure.

Side effects

Common side effects of this drug are:

  • Dizziness
  • Headache
  • Stomach ache
  • Diarrhoea
  • Indigestion
  • Nausea
  • Vomiting
  • Weakness
  • Rashes
  • Itching

Precautions and Warnings

Pregnancy

Pregnancy

Due to limited safety information available in pregnant women, Trimetazidine should be avoided during pregnancy. Consult your doctor if you are pregnant or think you may be or are planning for a baby before starting this medicine.

Breast Feeding

Breast Feeding

It is not known if trimetazidine passes into breast milk. Therefore, Trimetazidine should not be used during breastfeeding for the safety of the breastfed infant.

Driving

Driving

No, it is not advisable to drive or perform any tasks related to heavy machinery, as Trimetazidine tends to cause dizziness, loss of voluntary movement, stiffness in limbs, etc. These side effects can interfere with physical ability.

Alcohol

Alcohol

Alcohol consumption may alter the effect of Trimetazidine and increase the risk of side effects. Therefore, you should avoid consuming alcohol. Alcohol is also a critical factor that can induce angina. Thus, it should not be consumed when angina is detected.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have an eye condition called closed-angle Glaucoma.
  • If you have a brain disorder called Parkinson's Disease, this medicine can increase the symptoms.
  • You are an elderly patient older than 75 years.
  • You have severe kidney damage or kidney function problems.
  • You may experience tremors, impairment of movements and stiffness.

Mode of Action

How Does It Work?

Trimetazidine helps maintain cellular energy in heart muscles. This supports heart function during decreased oxygen conditions due to reduced blood supply.

Interactions

Interactions with other medicines

  • Some medicines can affect the way Trimetazidine works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
  • Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
  • Also, you should inform your doctor if you have a planned surgery or vaccination scheduled.

Interactions with food items

It is recommended to take Trimetazidine with food. This helps minimize gastrointestinal discomfort.

Dosage

Overdose

In case of an overdose of Trimetazidine, contact your doctor immediately or visit the nearest hospital.

Missed a Dose

If you missed any dose of Trimetazidine, take it as soon as you remember. If it's time for your next dose, skip the missed dose and continue with your regular dose schedule. Do not take a double dose of this medicine to compensate for the missed one.

Frequently Asked Questions (FAQs)

No, Trimetazidine should not be given to children as there is no safety information available in individuals below 18 years of age. Children have sensitive bodies and organs are not fully developed. Do not give any medicine to children without consulting a child specialist.

Consult your doctor before taking Trimetazidine. It would also be best if you discussed with your doctor about all the medication you are currently taking for treating your high blood pressure.

It acts by preventing the drop in levels of energy stores of heart cells and thus ensures the heart cells function optimally.

Trimetazidine is generally known to cause side effects like dizziness, headache, stomach ache, diarrhoea, indigestion, nausea, vomiting, weakness, rashes and itching.

Take Trimetazidine as directed by your doctor with a glass of water. Your doctor may suggest you take it with meals. Try to take this medicine at the same time each day for better results.

Trimetazidine works by maintaining the cellular energy of the heart muscles, thereby helping the heart muscles to function in conditions of decreased oxygen levels due to reduced blood supply. This medicine does not have any significant effect on blood pressure levels, heart rate or blood supply to the heart. Please consult your doctor before use.

No, Trimetazidine is not a blood thinner. It works by maintaining the energy supply of heart cells so that they function well when the oxygen supply is reduced, thus helping to ease chest pain.

Yes, they contain trimetazidine as the active component that belongs to the class of medicines acting on the heart.

You should take Trimetazidine as long as a doctor has prescribed you. It is usually prescribed for a longer duration. It is advised to take it regularly for a specific duration. Do not exceed the maximum daily doses and treatment durations recommended.

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