Rosuvastatin

Molecule Description

Rosuvastatin belongs to the statin family of medicines which are used to decrea

se the bad cholesterol, also known as Low-Density Lipoprotein (LDL) in the body.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Rosuvastatin

It is used in patients with high cholesterol levels, heart disease and high blood pressure. It is known to prevent stroke and reduce the risk of a heart attack.

Contraindications of Rosuvastatin

When should one not use Rosuvastatin

Any liver or kidney problems
Abnormal liver tests
Breastfeeding
Allergic to Rosuvastatin
Addiction to alcohol
If you are taking a medicine called Cyclosporin

Side effects of Rosuvastatin

Common side effects of this drug are:

Common side effects are headache, stomach pain, dizziness, heartburn, constipation and nausea
Serious side effect includes myopathy, which can manifest in the form of muscle ache, lethargy and fever
The patient should immediately report to the treating doctor if any signs of blood in the urine, along with muscle pain, is observed. It can cause jaundice and can elevate liver enzymes. Liver functio...
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Abnormal muscle breakdown (rhabdomyolysis) is a condition with severe muscle pain, soreness and may be associated with fever. This can be serious as it is related to the breakdown of muscles leading t...
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Promptly report to your doctor if you find dark-colored urine, fever, muscle pain

Precautions and Warnings of Rosuvastatin

Pregnancy

Can I take Rosuvastatin during pregnancy?

Do not take Rosuvastatin if you are pregnant or if you are planning pregnancy. Taking Rosuvastatin in pregnancy can be harmful to the foetus. Women of childbearing age should use effective contraceptive while using this medicine.

Breast Feeding

Can I take Rosuvastatin while breastfeeding?

A small amount of this medicine passes into breast milk. Limited data is available on safety about Rosuvastatin during breastfeeding. It is unsafe to consume this medicine if you are planning to breastfeed the baby.

Driving

Can I drive if I have consumed Rosuvastatin?

Rosuvastatin does not affect the ability to drive.

Alcohol

Can I consume alcohol with Rosuvastatin?

You must reduce the intake of alcohol while on Rosuvastatin medication, which otherwise can lead to liver damage.

Other General Warnings

Talk to your doctor if

You are taking or have taken in the last seven days a medicine called Fusidic Acid (an antibiotic for bacterial infection). Fusidic Acid and Rosuvastatin should not be taken together as they lead to s...
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You have kidney or liver problems
You have muscle aches or pains or family history of muscle problems
If in the past you had muscular problems during treatment with other cholesterol-lowering medicines
If you regularly drink alcohol

Mode of Action of Rosuvastatin

How Does It Work?

Cholesterol is made by an enzyme HMG-CoA reductase. Rosuvastatin inhibits this enzyme, thus lowering cholesterol and bad cholesterol (LDL) levels. It increases the good cholesterol, also known as high...

Interactions of Rosuvastatin

Interactions with other medicines

Increased risk of myopathy, when used with other lipid-lowering agents
Monitor lipid levels to ensure the lowest necessary dose of Rosuvastatin is used when given along with Amiodarone, Diltiazem or Verapamil
Many drugs like Cyclosporin, Warfarin, oral contraceptive pills, Itraconazole, Ketoconazole, Erythromycin, Clarithromycin, Telithromycin and HIV protease inhibitors have important interactions reducin...
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After taking Rosuvastatin within two hours, any antacids like aluminum hydroxide should not be taken
Rosuvastatin should not be taken along with Fusidic acid or within 7 days of stopping Fusidic acid as it will lead to a severe side effect of muscle breakdown (rhabdomyolysis)

Interactions with food items

Limit intake of grapefruit juice to minimal quantities.

Dosage of Rosuvastatin

Overdose

Although no particular side effects of overdose of Rosuvastatin are known, one must avoid overdose of any medicine. However, you may see the common side effects of Rosuvastatin in case of an overdose.

Missed a Dose

If you miss a dose of Rosuvastatin, take it as soon as you remember. However, do not take two dosages of Rosuvastatin within 12 hours gap between two doses.

Content Details

WRITTEN BY

Dr. Abhishek B L

MBBS, MD (Pharmacology)

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: How soon will Rosuvastatin work?

A: You may see results for lowering LDL cholesterol in 2–4 weeks after starting the medication of Rosuvastatin. Results may vary between individuals. On follow-up visits, your doctor may choose to adjust your dosage to help you reach your cholesterol goal.

Q: What are the precautions to follow?

These medicines are a part of a comprehensive program to reduce cholesterol levels. Avoid eating foods with high-fat content and exercise regularly for optimum results
Tell the doctor if you are pregnant or breastfeeding
Tell the doctor if you have any liver/ kidney ailment

Q: What if my daily schedule interferes with the dosage of medicine?

A: Try to take your dosages at the same time every day. Try connecting your dose with something you do every day, such as brushing your teeth or eating breakfast. This may help you remember to take it. Keep a daily calendar or set an alarm clock to go off at the time you need to take your medicine. You can also use a pillbox with the days of the week on it.

References

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Rosuvastatin. [Updated 2019 Jun 3].

Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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