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Molecule Description

Pyrazinamide is an anti-tuberculosis medicine that works by killing or preventing the growth of bacteria that causes tuberculosis (commonly called TB).

Uses of Pyrazinamide

This medicine is used to treat tuberculosis. It is an antibiotic that treats only bacterial infections. Pyrazinamide is always given in combination with other anti-tuberculosis agents.

Contraindications of Pyrazinamide

When should one not use Pyrazinamide

  • Severe liver damage
  • Diabetes
  • Gout or abnormal high amount of uric acid in blood
  • Habit of drinking too much of alcohol
  • Allergic reaction to this medicine and any of its components
  • Condition in which high porphyria seen in blood and urine

Side effects of Pyrazinamide

Common side effects of this drug are:

  • Nausea
  • Vomiting
  • Stomach upset
  • Loss of appetite
  • Mild muscle or joint pain
  • Fatigue

Precautions and Warnings of Pyrazinamide


Can I take Pyrazinamide during pregnancy?
This medication should be used only with the doctor's prescription.

Breast Feeding

Can I take Pyrazinamide while breastfeeding?
This medicine passes into breast milk and effects on a nursing infant. Hence it is not recommended during breastfeeding.


Can I drive if I have consumed Pyrazinamide?
There are no adequate evidences of this medicine regarding this aspect.


Can I consume alcohol with Pyrazinamide?
Alcoholic beverages should be avoided while doing this medication. It may increase the risk of liver disease.

Other General Warnings

Talk to your doctor if
  • If you have kidney disease
  • If you are diabetic
  • If you suffer from lactose intolerance
  • If any immunizations/ vaccinations while following Pyrazinamide medication, unless your doctor asks you to do so

Mode of Action of Pyrazinamide

How Does It Work?

This medicine stops the growth of organism mycobacterium tuberculosis. It reaches the site of infection where the tuberculosis bacteria releases chemicals and inhibits its action and thereby preventing the growth of these bacteria.
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Interactions of Pyrazinamide

Interactions with other medicines

This medicine has interactions with many medicines such as: Leflunomide, Teriflunomide, BCG vaccine, cholera vaccine, Isoniazid, Rifampicin, Lomitapide, Mipomersen, Brentuximab, Efavirenz, Tenofvir, Indium Oxyquinoline–III, Interferon Beta-1a, Bupropion, Clofarabine, Cyclosporine, Naltrexone, Epirubicin, Methotrexate, Morphine, Idelalisib, Allupurinol, etc.
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Interactions with food items

This medicine has interactions with food like aged cheese, few types of fish, dried meat, etc.

Dietary Restrictions of Pyrazinamide

You may need to avoid certain foods while you are taking Pyrazinamide. It includes red wine, aged cheese, dried meats and tuna or any other fish.

Dosage of Pyrazinamide


If anyone has overdosed with Pyrazinamide, one can suffer from breathing problems. Sputum test, kidney/ liver function, uric acid levels, complete blood count should be performed periodically.

Missed a Dose

If you miss a dose, take it as quick as possible. If it is near the time of the next dose, skip it and do not double the dose.

Content Details


Dr. Rukman Mecca

MBBS, MD (Community Medicine)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking this medicine?

A: Give a detailed account of your medical and surgical history. Also, mention to your doctor all the prescription and non-prescription medicines, herbal preparations and nutritional supplements that you may be taking before starting this medication.

Q: When and how to consume the medicine?

A: Take this medicine with a sufficient glass of water, with or without food.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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