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Methylprednisone / Methylprednisolone

Molecule Description

Methylprednisolone is a steroid hormone required by the body for multiple functions.

Uses of Methylprednisone / Methylprednisolone

Methylprednisolone is used to treat a variety of conditions including lung diseases like asthma, chronic obstructive pulmonary disease, acute bronchitis, joint diseases like arthritis, skin diseases eczema, intestine diseases like Crohn’s disease and ulcerative colitis or multiple sclerosis.
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Contraindications of Methylprednisone / Methylprednisolone

When should one not use Methylprednisone / Methylprednisolone

  • Allergic reaction to Methylprednisolone
  • Diabetes mellitus
  • If you had recently taken any vaccine
  • Increased blood pressure

Side effects of Methylprednisone / Methylprednisolone

Common side effects of this drug are:

  • Nausea, vomiting, stomach pain, diarrhea
  • Ulcers in the stomach that can bleed
  • Increased risk of getting infection
  • Reduced sleep
  • Mental health problems- Feeling depressed, suicidal thoughts, anxiety, seeing or feeling things that don’t exist
  • Changes in menstrual cycles
  • Allergic reactions such as skin rash, swelling of the face or wheezing and difficulty breathing
  • Blood clots or thrombosis in a leg vein
  • High blood pressure
  • Muscle weakness
  • Swelling, increased water and salt content in the body
  • Muscle cramps
  • Blurred vision, Increased pressure in the eye
  • Delayed growth in children
  • Increased appetite and weight gain
  • Worsening of existing diabetes
  • Acne

Precautions and Warnings of Methylprednisone / Methylprednisolone


Can I take Methylprednisone / Methylprednisolone during pregnancy?
This medicine should be avoided in pregnancy. This medicine crosses the placenta and can affect the baby, so it is unsafe to use during pregnancy. This medicine can slow the growth of the baby. If you are on this medicine and if you happen to be pregnant, do not stop this medicine abruptly on your own. Consult your doctor immediately.

Breast Feeding

Can I take Methylprednisone / Methylprednisolone while breastfeeding?
It is unsafe to use this medicine if you are breastfeeding, it can pass into the breast milk and can affect the growth of baby.


Can I drive if I have consumed Methylprednisone / Methylprednisolone?
Methylprednisolone does not affect your ability to drive. It can cause some people dizziness or vision problems. In such a scenario, avoid driving.


Can I consume alcohol with Methylprednisone / Methylprednisolone?
No known interaction with alcohol.

Other General Warnings

Talk to your doctor if
  • You have bleeding problems
  • Blood clots
  • Brittle bones (osteoporosis)
  • Diabetes eye diseases (such as cataracts, glaucoma, infection of the eye)
  • Heart problems (such as recent heart attack, congestive heart failure)
  • Kidney disease, liver disease
  • Stomach ulcer
  • Tuberculosis
  • Tumour of adrenal gland tissue - Pheochromocytoma
  • Mental/ mood conditions (such as psychosis, depression, anxiety)
  • Stomach problems

Interactions of Methylprednisone / Methylprednisolone

Interactions with other medicines

  • Aspirin
  • Rifampin
  • Phenytoin
  • Phenobarbital
  • Ketoconazole
  • Erythromycin
  • Digoxin
  • Inform your doctor if you have recently taken any vaccine

Interactions with food items

Grapefruit or its juice may interact with Methylprednisolone and lead to unwanted side effects.

Dietary Restrictions of Methylprednisone / Methylprednisolone

Potassium supplements is necessary.

Dosage of Methylprednisone / Methylprednisolone


Inform your doctor immediately in case of overdose. Symptoms of Methylprednisolone overdose can include (especially over long term overdose): altered mental status with agitation (psychosis), burning or itching skin, fits, deafness, depression, dry skin, high blood pressure, increased risk of infection, muscle weakness, nausea and vomiting, swelling in lower legs, ankles or feet, weak bones (osteoporosis) and bone fractures (seen with long-term use), weakness, nervousness, sleepiness, etc. Few of your existing health conditions such as acid reflux, ulcers and diabetes may worsen. In case you suspect acute or long term overdose symptoms, seek emergency medical attention immediately.
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Missed a Dose

If you missed any dose, take it as soon as you remember. Skip the missed dose if it is time for your next dose & do not take extra medicine to compensate for the missed dose.

Content Details


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: Any precautions before I start treatment?

A: Inform your doctor if you have diabetes mellitus as Methylprednisolone may increase sugar levels. Inform your doctor if you have recently received any live vaccine such as Measle Mumps and Rubella (MMR), chickenpox or flu.
Last Updated on: 24 Dec 2020 | 01:48 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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