Isosorbide Dinitrate

Molecule Description

Isosorbide Dinitrate is an ‘organic nitrate’ medicine used to treat heart diseas...
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Uses of Isosorbide Dinitrate

Prevention and treatment of angina (chest pain), which is caused by heart disease. It is used alone or with other medicines.

Contraindications of Isosorbide Dinitrate

When should one not use Isosorbide Dinitrate

  • Do not take this medicine if:
  • You are allergic to the medicine
  • Your haemoglobin count is low
  • You had a heart attack
  • You had a bleeding in the brain
  • You had a head injury
  • You had a low blood pressure
  • You have low blood volume
  • You are taking medicine such as Sildenafil or Riociguat

Side effects of Isosorbide Dinitrate

Common side effects of this drug are:

  • Swelling of face or throat
  • Giddiness
  • Headache at the start of treatment
  • Weakness
  • Dizziness
  • Tired feeling
  • Rapid heartbeat

Precautions and Warnings of Isosorbide Dinitrate



Can I take Isosorbide Dinitrate during pregnancy?
No data available for effects of this medicine in an unborn baby when taken during pregnancy, consult your doctor before taking this medicine.

Breast Feeding

Can I take Isosorbide Dinitrate while breastfeeding?
No data available whether this medicine passes into breast milk or not, consult your doctor before taking this medicine in breastfeeding.


Can I drive if I have consumed Isosorbide Dinitrate?
This medicine can cause dizziness, tiredness and headache; avoid driving in such a situation.


Can I consume alcohol with Isosorbide Dinitrate?
Drinking alcohol with this medicine can cause dizziness and fainting; avoid drinking if you are taking this medicine.

Other General Warnings

Talk to your doctor if
  • You have heart disease, liver disease, kidney disease, underactive thyroid gland (hypothyroidism) or lung disease
  • You are under nourished
  • You are taking medicines for high blood pressure, depression, anxiety, migraine or medical condition called phenylketonuria

Mode of Action of Isosorbide Dinitrate

How Does It Work?

This medicine works by relaxing and widening blood vessels so blood can flow more easily to the heart.

Interactions of Isosorbide Dinitrate

Interactions with other medicines

This medicine should not be taken with Phosphodiesterase inhibitors such as Sildenafil (which is used in erectile dysfunction) and Riociguat (which is used in pulmonary hypertension).

Interactions with food items

No information is available on interactions of Isosorbide Dinitrate when taken with food, consult your doctor or pharmacist for further details.

Dietary Restrictions of Isosorbide Dinitrate

No information is available on dietary restrictions while you are taking this medicine, consult your doctor or pharmacist for details.

Dosage of Isosorbide Dinitrate


Overdose symptoms may include severe headache, fever, confusion, dizziness or an episode of collapse. Consult with your doctor as soon as possible.

Missed a Dose

Take medicine as soon as you remember the missed dose. If your next dose is less than two hours away, skip the missed dose and use the medicine at your regular dosage schedule.

Content Details


Dr. Arpit Verma

MBBS, MD (Pharmacology)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking this medicine?

  • Talk to your doctor if:
  • You are malnourished (underfed)
  • You have liver or kidney disease
  • You suffer from shallow body temperature
  • You suffer from feeble circulation
  • You have been diagnosed with any of the heart conditions
  • You have an abnormally low level of oxygen in the blood and impaired gas exchange due to lung disease or ischaemic heart disease

Q: What should be the gap between two dosages of Isosorbide Dinitrate medicine?

A: There should be a minimum gap of 6 - 8 hours between two doses of this medicine.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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