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Molecule Description

Esomeprazole is a proton pump inhibitor. It belongs to the group of medicines w

hich decreases acid production in the stomach.


Uses of Esomeprazole

  • Stomach ulcer
  • Ulcer in the first part of intestine
  • Gastritis
  • A peculiar infection of the stomach called Helicobacter pylori infection. Here it is used along with antibiotics
  • Gastro-esophageal reflux disease also called heartburn. Reflux is the backflow of acid from the stomach into the food pipe which may become swollen and painful

Contraindications of Esomeprazole

When should one not use Esomeprazole

  • If you are allergic to Esomeprazole or any other medicines containing proton pump inhibitors (e.g. Pantoprazole, Lanzoprazole, Rabeprazole and Omeprazole)
  • If you are taking a medicine used to treat HIV infection
  • If you have or are suspected of having stomach cancer

Side effects of Esomeprazole

Common side effects of this drug are:

  • Headache
  • Stomachache, constipation or diarrhea along with flatulence are the most typical side effects
  • Nausea and vomiting
  • Allergic reactions, skin rash
  • Increased risk of infections is seen in long-term use
  • Decreased sodium and magnesium level in blood
  • Severe skin conditions blistering of skin, erosion of nose, mouth, lips, genitals (Steven Johnson syndrome) and sensitivity to light

Precautions and Warnings of Esomeprazole



Can I take Esomeprazole during pregnancy?
There are no adequate data from the use of Esomeprazole in pregnant women. If you are pregnant, you should use this medicine only if your doctor considers the benefit for you more significant than the potential risk for your unborn baby.

Breast Feeding

Can I take Esomeprazole while breastfeeding?
Accurate data of whether it passes into mother’s milk is not available. So, it is advisable to consult your doctor before taking this medicine during breastfeeding.


Can I drive if I have consumed Esomeprazole?
Esomeprazole has a negligible influence on the ability to drive. If you experience side effects like dizziness or disturbed vision, you should avoid driving.


Can I consume alcohol with Esomeprazole?
No interaction between alcohol and Esomeprazole has been reported. Drinking excess of alcohol results in acidity and heartburn. So avoid drinking in excess.

Other General Warnings

Talk to your doctor if
  • If you have had any past stomach surgery history
  • Have severe kidney problems
  • Have any liver problems or jaundice in which color of skin or eye becomes yellow
  • If you are more than 55 years and need to take this medicine on long term
  • Have ever had a skin reaction after treatment with a medicine similar to Esomeprazole that reduces stomach acid yellow
  • While taking this medicine, upon sun exposure if you get rashes on your skin, stop your treatment and inform your doctor as soon as you can
  • While taking this medicine, if you have severe diarrhea, tell your doctor immediately. Esomeprazole has been associated with a small increased risk of infectious diarrhea

Mode of Action of Esomeprazole

How Does It Work?

This medicine works by reducing the amount of acid that your stomach produces. A pump called the proton pump in the stomach is responsible for the secretion of stomach acids. Esomeprazole binds to thi...
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Interactions of Esomeprazole

Interactions with other medicines

  • Medicines such as Itraconazole, Ketoconazole (used to treat fungal infections) or Erlotinib, Methotrexate (used for certain types of cancer) as Esomeprazole tablets may interfere with the working of t...
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  • Medicines are given in HIV/AIDS patients (such as Nelfinavir, Tenofovir, Atazanavir, Rilpivirine, etc.)
  • Phenprocoumon and Warfarin, which affect the thickening or thinning of the blood

Interactions with food items

To be taken on an empty stomach. There are no known interactions with food or beverages. However, nicotine, caffeine (coffee, tea, chocolate and cola) and alcohol can stimulate stomach acid or delay u...
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Dietary Restrictions of Esomeprazole

  • Avoid spicy and fatty foods
  • Avoid late large meals before bedtime
  • Avoid fizzy cold drinks, coffee, chocolate and alcohol

Dosage of Esomeprazole


Overdose symptoms may include nausea, dry mouth, headache, drowsiness, blurred vision, fast heartbeat, sweating, flushing, shortness of breath, tremor, loss of coordination, confusion or seizure (conv...
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Missed a Dose

If you missed any dose, take it as soon as you remember. However, if it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose at a single...
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Content Details


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What special precautions should I follow?

A: It may cause colstridium difficile infection, diarrhea, atrophic gastritis and malabsorption syndrome if taken for a long term. Hence, it should be taken strictly on doctor’s advice and only for a period specified by doctor’s prescription. Do not extend its use on your own.

Q: When and how to consume the medicine?

  • It is given in the capsule form to be taken on an empty stomach
  • Esomeprazole sachets are also available for use in children
  • Intravenous preparations are also available to be used in acute conditions in hospital settings

Q: What should I tell my healthcare expert before starting this medication?

A: Some studies link Esomeprazole to stomach cancer. It is important to share if you have any personal or family history of stomach cancer. It is also essential for you to share information on the history of HIV/AIDS, liver cirrhosis or other critical conditions that you are suffering from. Also, disclose to your doctor all the ongoing medications and supplements that you are taking.

Q: How long can the medicine be taken?

A: It generally needs 5 days to 1 week for the onset of its action. Duration depends on the condition for which it is taken. It is usually prescribed in courses of 1-6 months duration. It may be given for an extended period too.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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