Duloxetine

Molecule Description

Duloxetine is a serotonin-norepinephrine reuptake inhibitor, i.e. increases the

level of serotonin in the nervous system of the body.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Duloxetine

Depression
Anxiety
Nerve pain or peripheral neuropathy in patients who suffer from diseases such as diabetes, fibromyalgia and arthritis

Contraindications of Duloxetine

When should one not use Duloxetine

Allergic reaction to Duloxetine
Antidepressants like Fluvoxamine
Antibiotics like Ciprofloxacin or Enoxacin
Any severe kidney, liver or heart problems like high blood pressure.

Side effects of Duloxetine

Common side effects of this drug are:

Nausea
Fatigue
Dry mouth
Sleepiness
Increased sweating
Loss of appetite
Constipation
Dizziness and headache
Liver damage
Serotonin syndrome
Vision problems
Hearing of abnormal sound in the ear (tinnitus)
Painful urination
Erectile problems
If you develop any unusual symptoms, consult a doctor immediately

Precautions and Warnings of Duloxetine

Pregnancy

Can I take Duloxetine during pregnancy?

It should be used in pregnant women only if necessary as it may affect the baby. Ensure that you consult your doctor if you are planning a pregnancy or are pregnant.

Breast Feeding

Can I take Duloxetine while breastfeeding?

It can be found in traces in breast milk. It has not shown to be harmful in any reports. Still, it is better to avoid this medicine during breastfeeding.

Driving

Can I drive if I have consumed Duloxetine?

You shouldn’t drive any vehicle or operate heavy machinery when under the influence of this medicine as it induces drowsiness and can cause dizziness.

Alcohol

Can I consume alcohol with Duloxetine?

You may continue to drink a small amount of alcohol while you are taking this medicine. However, excessive drinking may increase the symptoms of depression. Hence It is recommended not to drink alcohol.

Other General Warnings

Talk to your doctor if

If you are taking any depressant treatment
If you have any history of fits, eye diseases like glaucoma, bleeding tendencies
If you are taking Diuretics medicine for high blood pressure
It can severely increase the risk of having suicidal thoughts
It can cause drowsiness
It affects hormone (serotonin) levels in your brain causing confusion and agitation
It can increase the feeling of dizziness, especially when you stand up suddenly

Mode of Action of Duloxetine

How Does It Work?

Duloxetine helps you by improving your sleep, appetite, mood and energy levels. It will also help lower your nervousness. This medicine does this by restoring balance in the enzyme levels in the brain...

Interactions of Duloxetine

Interactions with other medicines

Duloxetine oral capsules may interact with other vitamins, medications or herbs you may be taking. An interaction is when a substance changes the way it works. This may be harmful or stop the medicine...
Read more
Serotonergic medicines like Triptans, Tryptophan, Lithium
Schizophrenia medicine like Thioridazine
Non Steroidal Anti-Inflammatory Drugs (NSAIDs) like Ibuprofen
Anticoagulants (blood thinners) Clopidogrel, Warfarin

Interactions with food items

There are no reports that show the Duloxetine interaction with food. It can be taken with or without food.

Dosage of Duloxetine

Overdose

In case of an overdose of Duloxetine, immediately contact your doctor. In case of overdose, you may experience tiredness, vomiting, increased heart rate, seizures, high blood pressure and dizziness.

Missed a Dose

If you missed any dose, take it as soon as you remember. If it is time for your next dose of medicine don’t take double dose, continue with prescribed dosage.

Content Details

WRITTEN BY

Dr. Ravi Kakarla

MBBS, MBA

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: How long does it take for the Duloxetine medicine to start working?

A: You will be able to see signs of improvement in energy, appetite and sleep within the first couple of weeks itself. These improvements are a good sign that the medication is working well. It will take about 6 to 8 weeks for depression and lack of interest in things to be cured.

Q: At what time of the day should you take Duloxetine?

A: It is highly recommended that you take medicine at the same time each day. People typically take it in the morning. However, if you feel that you may be drowsy throughout the day because of it, then you can take it in the evening as well. The capsules should be taken with a glass of water and swallowed whole.

Q: Is Duloxetine a painkiller?

A: It selectively inhibits the reuptake of norepinephrine and serotonin. It can be approved only with a prescription for chronic back pain and musculoskeletal pain, which is caused due to osteoarthritis.

Q: Can you take Ibuprofen along with Duloxetine?

A: Using this medicine with Ibuprofen has a high chance of causing bleeding. This interaction is more likely in the case of someone who has liver or kidney disease or if you are old.

Q: Does Duloxetine make you gain weight?

A: Studies have shown that weight gain doesn’t occur due to the medicine. Instead, you are more likely to lose weight.

References

Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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आंवला (Gooseberry in Hindi) के उपयोग, फ़ायदे और न्यूट्रिशनल वैल्यू

परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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