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Molecule Description

Diltiazem is mostly used to treat high blood pressure. It belongs to a group of medicines called calcium channel blockers (CCBs).

Uses of Diltiazem

  • High blood pressure
  • Angina (chest pain due to reduced oxygen supply to the heart muscles)

Contraindications of Diltiazem

When should one not use Diltiazem

  • Are allergic to Diltiazem or any other calcium channel antagonist
  • If you have heart failure
  • Have irregular or slow heartbeats

Side effects of Diltiazem

Common side effects of this drug are:

  • Swelling of hands, feet, and ankle
  • Nausea
  • Headache
  • Flushing
  • Skin rash
  • Tiredness
  • Feeling abnormal heartbeats
  • Dizziness
  • Stomach pain
  • Drowsiness
  • Difficulty sleeping

Precautions and Warnings of Diltiazem


Can I take Diltiazem during pregnancy?
Diltiazem is NOT considered safe for use during pregnancy.

Breast Feeding

Can I take Diltiazem while breastfeeding?
Whether Diltiazem passes into the mother’s milk is not exactly known. Limited data is available for this medicine during breastfeeding. Consult your doctor once while breastfeeding.


Can I drive if I have consumed Diltiazem?
Be cautious as Diltiazem may make you feel dizzy or sleepy.


Can I consume alcohol with Diltiazem?
Do not drink alcohol at the time of taking this medicine.

Other General Warnings

Talk to your doctor if
  • You have any medical history, especially of bowel problem
  • Have low blood pressure
  • Liver or kidney disease

Mode of Action of Diltiazem

How Does It Work?

Calcium ions are needed for active contraction of smooth muscles in the heart and blood vessels. Diltiazem inhibits transport of these calcium ions across membranes of heart cells and blood vessels. This inhibits cardiac and vascular smooth muscle contraction, thereby dilating the heart and arteries. Diltiazem reduces the load on the heart and decreases tension in blood vessels, thus lowering the blood pressure.
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Interactions of Diltiazem

Interactions with other medicines

  • Diltiazem
  • Dantrolene
  • Lomitapide
  • Nefazodone
  • Simvastatin
  • Ivacaftor
  • Flibanserin
  • Ivabradine (used to treat angina)
  • Medicines used to decrease cholesterol levels in (examples include Simvastatin, Atorvastatin or Lovastatin)

Interactions with food items

Grapefruit juice and grapefruit should not be consumed by people who are taking Diltiazem as these can cause a drastic drop in blood pressure.

Dietary Restrictions of Diltiazem

If your doctor advised you a low-salt or low-sodium diet, follow these directions carefully.

Dosage of Diltiazem


You may experience slow, fast, or irregular heartbeat, fainting, difficulty in breathing, fits, dizziness, confusion, vomiting, and increased sweating. Seek emergency help in case of an overdose.

Missed a Dose

It is ideal not to miss a dose. The missed dose can be taken when you remember it if there is sufficient time left for the next scheduled dose. Do not compensate for the missed dose by taking an extra dose.
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Content Details


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: What should I discuss with my healthcare expert before taking Diltiazem?

A: You should give details of all the medications you are on before starting this medicine. Tell your doctor if you have or ever had a heart attack or heart or liver disease. Tell your doctor if you are pregnant, plan to be pregnant or are breastfeeding.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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