Dapsone
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Molecule Description
Dapsone is an anti-infective medicine used for the treatment of certain skin diseases and leprosy and to prevent infections such as malaria and pneumonia.
Uses
- Treatment of leprosy (a bacterial infection that affects the skin and nerves), in combination with other medicines
- Treatment of a chronic itchy skin rash with blisters (dermatitis herpetiformis) which is caused by an overactive immune system, or any other similar skin reactions
- Prevention of malaria, in combination with another medicine called Pyrimethamine
- Prevention of pneumonia (a lung infection caused by Pneumocystis Carinii) in patients with weakened immune systems, especially in AIDS patients
Contraindications
When should one not use Dapsone
- Allergy to Dapsone or any other components of the medicine
- Severe anaemia
- A genetic or inherited disorder causing accumulation of substances related to the production of red blood cells (porphyria)
- Another genetic disorder that causes increased breakdown of red blood cells ( Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency)
Side effects
Common side effects of this drug are:
- Fever, rashes, skin reactions, liver and kidney problems, mental illness (Dapsone syndrome)
- Decrease in red blood cells (anaemia)
- Tingling (due to nerve damage), redness or burning of the skin
- Feeling sick, decreased hunger, liver problems (jaundice)
- Fast heart rate
- Mental disturbances (mood and behavioral changes, anxiety)
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- Any heart or lung disease
- Decreased blood cell count (anaemia)
- Blood cell count tests should be performed regularly while on treatment with Dapsone
Mode of Action
How Does It Work?
It works by stopping the production of folic acid in certain bacteria, which is essential for the growth of bacteria like Mycobacterium Leprae and Pneumocystis Carinii.
Interactions
Interactions with other medicines
- Probenecid (used to treat gout)
- Rifampicin or Trimethoprim (medicines used to treat bacterial infections)
Interactions with food items
Dapsone does not interact with food. You can take it before or after meals.
Dosage
Overdose
Accidental overdose of Dapsone may not be harmful. But, high overdose can cause destruction of red blood cells, shortness of breath, etc. and can be harmful. Inform your doctor and seek medical attention without delay if you notice any symptoms.
Missed a Dose
Take Dapsone as soon as you remember the missed dose. If it is almost time for your next dose (less than 8 hours), skip the missed dose and go back to regular dose schedule. Do not take a double dose to compensate for the missed dose.
Frequently Asked Questions (FAQs)
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